{
  "resourceType" : "DiagnosticReport",
  "id" : "mii-exa-molgen-befundbericht-1",
  "meta" : {
    "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-molgen/StructureDefinition/molekulargenetischer-befundbericht|2027.0.0-ballot.1",
    "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-report|3.0.0"]
  },
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><div xml:lang=\"en\" lang=\"en\"><hr/><p><b>English</b></p><hr/><p class=\"res-header-id\"><b>Generated Narrative: DiagnosticReport mii-exa-molgen-befundbericht-1</b></p><a name=\"mii-exa-molgen-befundbericht-1\"> </a><a name=\"hcmii-exa-molgen-befundbericht-1\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profiles: <a href=\"StructureDefinition-mii-pr-molgen-molekulargenetischer-befundbericht.html\">MII PR MolGen Molekulargenetischer Befundbericht</a> version: 2027.0.0-ballot.1, <a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU3/StructureDefinition-genomic-report.html\">Genomic Report</a> version: 3.0.0</p></div><h2><span title=\"Codes:{http://loinc.org 51969-4}\">Genetic analysis report</span> (<span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>) </h2><table class=\"grid\"><tr><td>Subject</td><td>Maja Julia Van-der-Dussen (official) Female, DoB: 1968-09-19 ( Medical record number\u00a0(use:\u00a0usual,\u00a0))</td></tr><tr><td>Performer</td><td> <a href=\"Practitioner-mii-exa-molgen-practitioner-lab.html\">Practitioner Dr. Daniel Schmidt(official)</a></td></tr></table><p><b>Report Details</b></p><table class=\"grid\"><tr><td><b>Code</b></td><td><b>Value</b></td><td><b>Flags</b></td><td><b>Relevant Time</b></td></tr><tr><td><a href=\"Observation-mii-exa-molgen-diagnostische-implikation-1.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}\">Diagnostic Implication</span></a></td><td/><td>Final</td><td>2022-04-07</td></tr><tr><td><a href=\"Observation-mii-exa-molgen-therapeutische-implikation-1.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></a></td><td/><td>Final</td><td>2022-04-07</td></tr><tr><td><a href=\"Observation-mii-exa-molgen-variante-1.html\"><span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></a></td><td><span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></td><td>Final</td><td>2022-04-07</td></tr><tr><td><a href=\"Observation-mii-exa-molgen-genotyp-1.html\"><span title=\"Codes:{http://loinc.org 84413-4}\">Genotype display name</span></a></td><td><span title=\"Codes:\">BRAF rs113488022 T&gt;A</span></td><td>Final</td><td>2022-04-07</td></tr><tr><td><a href=\"Observation-mii-exa-molgen-mutationslast-1.html\"><span title=\"Codes:{http://loinc.org 94076-7}\">Mutations/Megabase [# Ratio] in Tumor</span></a></td><td>12 Mutations/Megabase<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  code1/1000000{Base} = '1/1000000{Base}')</span></td><td>Final</td><td/></tr><tr><td><a href=\"Observation-mii-exa-molgen-mikrosatelliteninstabilitaet-1.html\"><span title=\"Codes:{http://loinc.org 81695-9}\">Microsatellite instability [Interpretation] in Cancer specimen Qualitative</span></a></td><td><span title=\"Codes:{http://loinc.org LA14122-8}\">Stable</span></td><td>Final</td><td/></tr></table><p>BRAF p.V600E Mutation liegt vor. Bitte Therapieoption mit einem BRAF-Inhibitor prüfen.</p></div><div xml:lang=\"de\" lang=\"de\"><hr/><p><b>German</b></p><hr/><p class=\"res-header-id\"><b>Generated Narrative: DiagnosticReport mii-exa-molgen-befundbericht-1</b></p><a name=\"de-mii-exa-molgen-befundbericht-1\"> </a><a name=\"de-hcmii-exa-molgen-befundbericht-1\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profiles: <a href=\"StructureDefinition-mii-pr-molgen-molekulargenetischer-befundbericht.html\">MII PR MolGen Molekulargenetischer Befundbericht</a> version: 2027.0.0-ballot.1, <a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU3/StructureDefinition-genomic-report.html\">Genomic Report</a> version: 3.0.0</p></div><h2><span title=\"Codes:{http://loinc.org 51969-4}\">Genetic analysis report</span> (<span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>) </h2><table class=\"grid\"><tr><td>Subject</td><td>Maja Julia Van-der-Dussen (official) Female, DoB: 1968-09-19 ( Krankenaktennummer\u00a0(use:\u00a0usual,\u00a0))</td></tr><tr><td>Performer</td><td> <a href=\"Practitioner-mii-exa-molgen-practitioner-lab.html\">Practitioner Dr. Daniel Schmidt(official)</a></td></tr></table><p><b>Report Details</b></p><table class=\"grid\"><tr><td><b>Code</b></td><td><b>Value</b></td><td><b>Flags</b></td><td><b>Relevant Time</b></td></tr><tr><td><a href=\"Observation-mii-exa-molgen-diagnostische-implikation-1.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}\">Diagnostic Implication</span></a></td><td/><td>Final</td><td>2022-04-07</td></tr><tr><td><a href=\"Observation-mii-exa-molgen-therapeutische-implikation-1.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></a></td><td/><td>Final</td><td>2022-04-07</td></tr><tr><td><a href=\"Observation-mii-exa-molgen-variante-1.html\"><span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></a></td><td><span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></td><td>Final</td><td>2022-04-07</td></tr><tr><td><a href=\"Observation-mii-exa-molgen-genotyp-1.html\"><span title=\"Codes:{http://loinc.org 84413-4}\">Genotype display name</span></a></td><td><span title=\"Codes:\">BRAF rs113488022 T&gt;A</span></td><td>Final</td><td>2022-04-07</td></tr><tr><td><a href=\"Observation-mii-exa-molgen-mutationslast-1.html\"><span title=\"Codes:{http://loinc.org 94076-7}\">Mutations/Megabase [# Ratio] in Tumor</span></a></td><td>12 Mutations/Megabase<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  code1/1000000{Base} = '1/1000000{Base}')</span></td><td>Final</td><td/></tr><tr><td><a href=\"Observation-mii-exa-molgen-mikrosatelliteninstabilitaet-1.html\"><span title=\"Codes:{http://loinc.org 81695-9}\">Microsatellite instability [Interpretation] in Cancer specimen Qualitative</span></a></td><td><span title=\"Codes:{http://loinc.org LA14122-8}\">Stable</span></td><td>Final</td><td/></tr></table><p>BRAF p.V600E Mutation liegt vor. Bitte Therapieoption mit einem BRAF-Inhibitor prüfen.</p></div></div>"
  },
  "extension" : [{
    "url" : "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-reference",
    "valueReference" : {
      "reference" : "Procedure/mii-exa-molgen-genomic-study-1"
    }
  },
  {
    "url" : "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/recommended-action",
    "valueReference" : {
      "reference" : "Task/mii-exa-molgen-medikationsempfehlung-1"
    }
  },
  {
    "url" : "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/recommended-action",
    "valueReference" : {
      "reference" : "Task/mii-exa-molgen-folgemassnahme-1"
    }
  },
  {
    "url" : "http://hl7.org/fhir/StructureDefinition/workflow-supportingInfo",
    "valueReference" : {
      "reference" : "FamilyMemberHistory/mii-exa-molgen-family-member-history-1"
    }
  }],
  "basedOn" : [{
    "reference" : "ServiceRequest/mii-exa-molgen-anforderung-1"
  }],
  "status" : "final",
  "category" : [{
    "coding" : [{
      "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
      "code" : "GE",
      "display" : "Genetics"
    }]
  }],
  "code" : {
    "coding" : [{
      "system" : "http://loinc.org",
      "code" : "51969-4",
      "display" : "Genetic analysis report"
    }]
  },
  "subject" : {
    "reference" : "Patient/mii-exa-molgen-patient"
  },
  "performer" : [{
    "reference" : "Practitioner/mii-exa-molgen-practitioner-lab"
  }],
  "specimen" : [{
    "reference" : "Specimen/mii-exa-molgen-specimen-1"
  }],
  "result" : [{
    "reference" : "Observation/mii-exa-molgen-diagnostische-implikation-1"
  },
  {
    "reference" : "Observation/mii-exa-molgen-therapeutische-implikation-1"
  },
  {
    "reference" : "Observation/mii-exa-molgen-variante-1"
  },
  {
    "reference" : "Observation/mii-exa-molgen-genotyp-1"
  },
  {
    "reference" : "Observation/mii-exa-molgen-mutationslast-1"
  },
  {
    "reference" : "Observation/mii-exa-molgen-mikrosatelliteninstabilitaet-1"
  }],
  "conclusion" : "BRAF p.V600E Mutation liegt vor. Bitte Therapieoption mit einem BRAF-Inhibitor prüfen."
}