{
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  "id" : "mii-exa-befund-bundle-1-braf",
  "language" : "de",
  "type" : "transaction",
  "timestamp" : "2022-07-14T12:11:00+01:00",
  "entry" : [{
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      "resourceType" : "DiagnosticReport",
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        "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-report|3.0.0"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "extension" : [{
        "url" : "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-reference",
        "valueReference" : {
          "reference" : "Procedure/mii-exa-molgen-genomic-study-1"
        }
      },
      {
        "url" : "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/recommended-action",
        "valueReference" : {
          "reference" : "Task/mii-exa-molgen-medikationsempfehlung-1"
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      },
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          "reference" : "Task/mii-exa-molgen-folgemassnahme-1"
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      },
      {
        "url" : "http://hl7.org/fhir/StructureDefinition/workflow-supportingInfo",
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          "reference" : "FamilyMemberHistory/mii-exa-molgen-family-member-history-1"
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      }],
      "basedOn" : [{
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      "category" : [{
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      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
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          "display" : "Genetic analysis report"
        }]
      },
      "subject" : {
        "reference" : "Patient/mii-exa-molgen-patient"
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      "performer" : [{
        "reference" : "Practitioner/mii-exa-molgen-practitioner-lab"
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        "reference" : "Observation/mii-exa-molgen-therapeutische-implikation-1"
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      {
        "reference" : "Observation/mii-exa-molgen-variante-1"
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      {
        "reference" : "Observation/mii-exa-molgen-genotyp-1"
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        "reference" : "Observation/mii-exa-molgen-mutationslast-1"
      },
      {
        "reference" : "Observation/mii-exa-molgen-mikrosatelliteninstabilitaet-1"
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      "status" : "requested",
      "intent" : "proposal",
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "LA26421-0",
          "display" : "Consider alternative medication"
        }],
        "text" : "Alternative Medikation in Erwägung ziehen"
      },
      "for" : {
        "reference" : "Patient/mii-exa-molgen-patient"
      },
      "reasonReference" : {
        "reference" : "Observation/mii-exa-molgen-therapeutische-implikation-1"
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    },
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  },
  {
    "fullUrl" : "https://www.medizininformatik-initiative.de/fhir/example-mii-molgen-folgemassnahme-1",
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      "resourceType" : "Task",
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      "language" : "de",
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        "status" : "generated"
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      "status" : "requested",
      "intent" : "proposal",
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        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "LA14020-4",
          "display" : "Genetic counseling recommended"
        }]
      },
      "description" : "Genetische Beratung empfohlen mit Dr. Rosalind Franklin",
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        "reference" : "Patient/mii-exa-molgen-patient"
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      "reasonReference" : {
        "reference" : "Observation/mii-exa-molgen-therapeutische-implikation-1"
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      "method" : "PUT",
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  },
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    "fullUrl" : "https://www.medizininformatik-initiative.de/fhir/mii-exa-molgen-family-member-history-1",
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      "resourceType" : "FamilyMemberHistory",
      "id" : "mii-exa-molgen-family-member-history-1",
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        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-molgen/StructureDefinition/familienanamnese|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "completed",
      "patient" : {
        "reference" : "Patient/mii-exa-molgen-patient"
      },
      "date" : "2022-04-07",
      "relationship" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "72705000",
          "display" : "Mother (person)"
        },
        {
          "system" : "http://terminology.hl7.org/CodeSystem/v3-RoleCode",
          "code" : "MTH",
          "display" : "mother"
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      },
      "sex" : {
        "coding" : [{
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          "system" : "http://snomed.info/sct",
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      "deceasedBoolean" : true,
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          "coding" : [{
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          }]
        },
        "contributedToDeath" : true
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "FamilyMemberHistory/mii-exa-molgen-family-member-history-1"
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  },
  {
    "fullUrl" : "https://www.medizininformatik-initiative.de/fhir/mii-exa-molgen-anforderung-1",
    "resource" : {
      "resourceType" : "ServiceRequest",
      "id" : "mii-exa-molgen-anforderung-1",
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        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-molgen/StructureDefinition/anforderung-genetischer-test|2027.0.0-ballot.1"]
      },
      "language" : "de",
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        "status" : "generated"
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      "status" : "active",
      "intent" : "order",
      "category" : [{
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "108252007",
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        "coding" : [{
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          "system" : "http://loinc.org",
          "code" : "53844-7",
          "display" : "BRAF gene targeted mutation analysis in Blood or Tissue by Molecular genetics method"
        },
        {
          "system" : "http://www.genenames.org/geneId",
          "code" : "HGNC:1097",
          "display" : "BRAF"
        }],
        "text" : "BRAF: Exon 15 (Codon 600)"
      },
      "subject" : {
        "reference" : "Patient/mii-exa-molgen-patient"
      },
      "authoredOn" : "2022-04-07",
      "requester" : {
        "reference" : "Practitioner/mii-exa-molgen-practitioner-physician"
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      "specimen" : [{
        "reference" : "Specimen/mii-exa-molgen-specimen-1"
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    },
    "request" : {
      "method" : "PUT",
      "url" : "ServiceRequest/mii-exa-molgen-anforderung-1"
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  },
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    "fullUrl" : "https://www.medizininformatik-initiative.de/fhir/example-mii-molgen-patient",
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        "value" : "42285243",
        "assigner" : {
          "identifier" : {
            "system" : "https://www.medizininformatik-initiative.de/fhir/core/CodeSystem/core-location-identifier",
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          },
          "display" : "Charité - Universitätsmedizin Berlin"
        }
      },
      {
        "use" : "official",
        "type" : {
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        },
        "system" : "http://fhir.de/sid/gkv/kvid-10",
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        "assigner" : {
          "identifier" : {
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            "system" : "http://fhir.de/sid/arge-ik/iknr",
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        }
      },
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        "value" : "123456",
        "assigner" : {
          "display" : "Signal Iduna"
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        "family" : "Van-der-Dussen",
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            "url" : "http://hl7.org/fhir/StructureDefinition/humanname-own-name",
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        },
        "given" : ["Maja",
        "Julia"],
        "prefix" : ["Prof. Dr. med."],
        "_prefix" : [{
          "extension" : [{
            "url" : "http://hl7.org/fhir/StructureDefinition/iso21090-EN-qualifier",
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        }]
      },
      {
        "use" : "maiden",
        "family" : "Haffer"
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      "gender" : "female",
      "birthDate" : "1968-09-19",
      "deceasedBoolean" : false,
      "address" : [{
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        "line" : ["Anna-Louisa-Karsch Str. 2"],
        "city" : "Berlin",
        "state" : "DE-BE",
        "postalCode" : "10178",
        "country" : "DE"
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "Patient/mii-exa-molgen-patient"
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  },
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        "text" : "Dr. Daniel Schmidt",
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        "prefix" : ["Dr."]
      }]
    },
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    "fullUrl" : "https://www.medizininformatik-initiative.de/fhir/example-mii-molgen-specimen-1",
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      "resourceType" : "Specimen",
      "id" : "mii-exa-molgen-specimen-1",
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        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "identifier" : [{
        "system" : "https://biobank.uk-musterstadt.de/fhir/sid/proben",
        "value" : "5432"
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      "status" : "available",
      "type" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
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        "reference" : "Patient/mii-exa-molgen-patient"
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      "collection" : {
        "collectedDateTime" : "2022-03-24T12:44:00+01:00",
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        }
      }
    },
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      "url" : "Specimen/mii-exa-molgen-specimen-1"
    }
  },
  {
    "fullUrl" : "https://www.medizininformatik-initiative.de/fhir/mii-exa-molgen-diagnostische-implikation-1",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "mii-exa-molgen-diagnostische-implikation-1",
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        "coding" : [{
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          "display" : "Diagnostic Implication"
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        },
        "valueString" : "Nachweis einer aktivierenden Mutation BRAF V600E"
      }]
    },
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  },
  {
    "fullUrl" : "https://www.medizininformatik-initiative.de/fhir/mii-exa-molgen-therapeutische-implikation-1",
    "resource" : {
      "resourceType" : "Observation",
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      },
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      "effectiveDateTime" : "2022-04-07",
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          {
            "system" : "http://snomed.info/sct",
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        }
      },
      {
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          "coding" : [{
            "system" : "http://www.whocc.no/atc",
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            "display" : "EGFR (Epidermal Growth Factor Receptor) inhibitors"
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        }
      },
      {
        "code" : {
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            "code" : "51963-7",
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        "valueCodeableConcept" : {
          "coding" : [{
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            "code" : "L01EE",
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    },
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