<?xml version="1.0" encoding="UTF-8"?>

<Bundle xmlns="http://hl7.org/fhir">
  <id value="mii-exa-befund-bundle-1-braf"/>
  <language value="de"/>
  <type value="transaction"/>
  <timestamp value="2022-07-14T12:11:00+01:00"/>
  <entry>
    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/mii-exa-molgen-befundbericht-1"/>
    <resource>
      <DiagnosticReport>
        <id value="mii-exa-molgen-befundbericht-1"/>
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          <profile value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-report|3.0.0"/>
        </meta>
        <language value="de"/>
        <text>
          <status value="generated"/>
        </text>
        <extension url="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-reference">
          <valueReference>
            <reference value="Procedure/mii-exa-molgen-genomic-study-1"/>
          </valueReference>
        </extension>
        <extension url="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/recommended-action">
          <valueReference>
            <reference value="Task/mii-exa-molgen-medikationsempfehlung-1"/>
          </valueReference>
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        <extension url="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/recommended-action">
          <valueReference>
            <reference value="Task/mii-exa-molgen-folgemassnahme-1"/>
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        </extension>
        <extension url="http://hl7.org/fhir/StructureDefinition/workflow-supportingInfo">
          <valueReference>
            <reference value="FamilyMemberHistory/mii-exa-molgen-family-member-history-1"/>
          </valueReference>
        </extension>
        <basedOn>
          <reference value="ServiceRequest/mii-exa-molgen-anforderung-1"/>
        </basedOn>
        <status value="final"/>
        <category>
          <coding>
            <system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
            <code value="GE"/>
            <display value="Genetics"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="51969-4"/>
            <display value="Genetic analysis report"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/mii-exa-molgen-patient"/>
        </subject>
        <performer>
          <reference value="Practitioner/mii-exa-molgen-practitioner-lab"/>
        </performer>
        <specimen>
          <reference value="Specimen/mii-exa-molgen-specimen-1"/>
        </specimen>
        <result>
          <reference value="Observation/mii-exa-molgen-diagnostische-implikation-1"/>
        </result>
        <result>
          <reference value="Observation/mii-exa-molgen-therapeutische-implikation-1"/>
        </result>
        <result>
          <reference value="Observation/mii-exa-molgen-variante-1"/>
        </result>
        <result>
          <reference value="Observation/mii-exa-molgen-genotyp-1"/>
        </result>
        <result>
          <reference value="Observation/mii-exa-molgen-mutationslast-1"/>
        </result>
        <result>
          <reference value="Observation/mii-exa-molgen-mikrosatelliteninstabilitaet-1"/>
        </result>
        <conclusion value="BRAF p.V600E Mutation liegt vor. Bitte Therapieoption mit einem BRAF-Inhibitor prüfen."/>
      </DiagnosticReport>
    </resource>
    <request>
      <method value="PUT"/>
      <url value="DiagnosticReport/mii-exa-molgen-befundbericht-1"/>
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  </entry>
  <entry>
    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/mii-exa-molgen-medikationsempfehlung-1"/>
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      <Task>
        <id value="mii-exa-molgen-medikationsempfehlung-1"/>
        <meta>
          <profile value="https://www.medizininformatik-initiative.de/fhir/ext/modul-molgen/StructureDefinition/medikationsempfehlung|2027.0.0-ballot.1"/>
          <profile value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/medication-recommendation|3.0.0"/>
        </meta>
        <language value="de"/>
        <text>
          <status value="generated"/>
        </text>
        <basedOn>
          <reference value="ServiceRequest/mii-exa-molgen-anforderung-1"/>
        </basedOn>
        <status value="requested"/>
        <intent value="proposal"/>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA26421-0"/>
            <display value="Consider alternative medication"/>
          </coding>
          <text value="Alternative Medikation in Erwägung ziehen"/>
        </code>
        <for>
          <reference value="Patient/mii-exa-molgen-patient"/>
        </for>
        <reasonReference>
          <reference value="Observation/mii-exa-molgen-therapeutische-implikation-1"/>
        </reasonReference>
      </Task>
    </resource>
    <request>
      <method value="PUT"/>
      <url value="Task/mii-exa-molgen-medikationsempfehlung-1"/>
    </request>
  </entry>
  <entry>
    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/example-mii-molgen-folgemassnahme-1"/>
    <resource>
      <Task>
        <id value="mii-exa-molgen-folgemassnahme-1"/>
        <meta>
          <profile value="https://www.medizininformatik-initiative.de/fhir/ext/modul-molgen/StructureDefinition/empfohlene-folgemassnahme|2027.0.0-ballot.1"/>
          <profile value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/followup-recommendation|3.0.0"/>
        </meta>
        <language value="de"/>
        <text>
          <status value="generated"/>
        </text>
        <basedOn>
          <reference value="ServiceRequest/mii-exa-molgen-anforderung-1"/>
        </basedOn>
        <status value="requested"/>
        <intent value="proposal"/>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA14020-4"/>
            <display value="Genetic counseling recommended"/>
          </coding>
        </code>
        <description value="Genetische Beratung empfohlen mit Dr. Rosalind Franklin"/>
        <for>
          <reference value="Patient/mii-exa-molgen-patient"/>
        </for>
        <reasonReference>
          <reference value="Observation/mii-exa-molgen-therapeutische-implikation-1"/>
        </reasonReference>
      </Task>
    </resource>
    <request>
      <method value="PUT"/>
      <url value="Task/mii-exa-molgen-folgemassnahme-1"/>
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  </entry>
  <entry>
    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/mii-exa-molgen-family-member-history-1"/>
    <resource>
      <FamilyMemberHistory>
        <id value="mii-exa-molgen-family-member-history-1"/>
        <meta>
          <profile value="https://www.medizininformatik-initiative.de/fhir/ext/modul-molgen/StructureDefinition/familienanamnese|2027.0.0-ballot.1"/>
        </meta>
        <language value="de"/>
        <text>
          <status value="generated"/>
        </text>
        <status value="completed"/>
        <patient>
          <reference value="Patient/mii-exa-molgen-patient"/>
        </patient>
        <date value="2022-04-07"/>
        <relationship>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="72705000"/>
            <display value="Mother (person)"/>
          </coding>
          <coding>
            <system value="http://terminology.hl7.org/CodeSystem/v3-RoleCode"/>
            <code value="MTH"/>
            <display value="mother"/>
          </coding>
        </relationship>
        <sex>
          <coding>
            <system value="http://hl7.org/fhir/administrative-gender"/>
            <code value="female"/>
          </coding>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="248152002"/>
            <display value="Female (finding)"/>
          </coding>
        </sex>
        <deceasedBoolean value="true"/>
        <reasonCode>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="447886005"/>
            <display value="Adenocarcinoma of anorectum (disorder)"/>
          </coding>
        </reasonCode>
        <condition>
          <code>
            <coding>
              <system value="http://snomed.info/sct"/>
              <code value="830150003"/>
              <display value="Malignant melanoma with B-Raf proto-oncogene, serine/threonine kinase V600E mutation (disorder)"/>
            </coding>
          </code>
          <contributedToDeath value="true"/>
        </condition>
      </FamilyMemberHistory>
    </resource>
    <request>
      <method value="PUT"/>
      <url value="FamilyMemberHistory/mii-exa-molgen-family-member-history-1"/>
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  </entry>
  <entry>
    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/mii-exa-molgen-anforderung-1"/>
    <resource>
      <ServiceRequest>
        <id value="mii-exa-molgen-anforderung-1"/>
        <meta>
          <profile value="https://www.medizininformatik-initiative.de/fhir/ext/modul-molgen/StructureDefinition/anforderung-genetischer-test|2027.0.0-ballot.1"/>
        </meta>
        <language value="de"/>
        <text>
          <status value="generated"/>
        </text>
        <status value="active"/>
        <intent value="order"/>
        <category>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="108252007"/>
            <display value="Laboratory procedure (procedure)"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="405825005"/>
            <display value="Molecular genetic test (procedure)"/>
          </coding>
          <coding>
            <system value="http://loinc.org"/>
            <code value="53844-7"/>
            <display value="BRAF gene targeted mutation analysis in Blood or Tissue by Molecular genetics method"/>
          </coding>
          <coding>
            <system value="http://www.genenames.org/geneId"/>
            <code value="HGNC:1097"/>
            <display value="BRAF"/>
          </coding>
          <text value="BRAF: Exon 15 (Codon 600)"/>
        </code>
        <subject>
          <reference value="Patient/mii-exa-molgen-patient"/>
        </subject>
        <authoredOn value="2022-04-07"/>
        <requester>
          <reference value="Practitioner/mii-exa-molgen-practitioner-physician"/>
        </requester>
        <reasonCode>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="447886005"/>
            <display value="Adenocarcinoma of anorectum (disorder)"/>
          </coding>
        </reasonCode>
        <supportingInfo>
          <reference value="FamilyMemberHistory/mii-exa-molgen-family-member-history-1"/>
        </supportingInfo>
        <specimen>
          <reference value="Specimen/mii-exa-molgen-specimen-1"/>
        </specimen>
      </ServiceRequest>
    </resource>
    <request>
      <method value="PUT"/>
      <url value="ServiceRequest/mii-exa-molgen-anforderung-1"/>
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  </entry>
  <entry>
    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/example-mii-molgen-patient"/>
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      <Patient>
        <id value="mii-exa-molgen-patient"/>
        <language value="de"/>
        <text>
          <status value="generated"/>
        </text>
        <identifier>
          <use value="usual"/>
          <type>
            <coding>
              <system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
              <code value="MR"/>
            </coding>
          </type>
          <system value="https://www.medizininformatik-initiative.de/fhir/sid/patienten"/>
          <value value="42285243"/>
          <assigner>
            <identifier>
              <system value="https://www.medizininformatik-initiative.de/fhir/core/CodeSystem/core-location-identifier"/>
              <value value="Charité"/>
            </identifier>
            <display value="Charité - Universitätsmedizin Berlin"/>
          </assigner>
        </identifier>
        <identifier>
          <use value="official"/>
          <type>
            <coding>
              <system value="http://fhir.de/CodeSystem/identifier-type-de-basis"/>
              <code value="GKV"/>
            </coding>
          </type>
          <system value="http://fhir.de/sid/gkv/kvid-10"/>
          <value value="Z234567890"/>
          <assigner>
            <identifier>
              <use value="official"/>
              <system value="http://fhir.de/sid/arge-ik/iknr"/>
              <value value="109519005"/>
            </identifier>
          </assigner>
        </identifier>
        <identifier>
          <use value="secondary"/>
          <type>
            <coding>
              <system value="http://fhir.de/CodeSystem/identifier-type-de-basis"/>
              <code value="PKV"/>
            </coding>
          </type>
          <value value="123456"/>
          <assigner>
            <display value="Signal Iduna"/>
          </assigner>
        </identifier>
        <name>
          <use value="official"/>
          <family value="Van-der-Dussen">
            <extension url="http://hl7.org/fhir/StructureDefinition/humanname-own-name">
              <valueString value="Van-der-Dussen"/>
            </extension>
          </family>
          <given value="Maja"/>
          <given value="Julia"/>
          <prefix value="Prof. Dr. med.">
            <extension url="http://hl7.org/fhir/StructureDefinition/iso21090-EN-qualifier">
              <valueCode value="AC"/>
            </extension>
          </prefix>
        </name>
        <name>
          <use value="maiden"/>
          <family value="Haffer"/>
        </name>
        <gender value="female"/>
        <birthDate value="1968-09-19"/>
        <deceasedBoolean value="false"/>
        <address>
          <type value="both"/>
          <line value="Anna-Louisa-Karsch Str. 2"/>
          <city value="Berlin"/>
          <state value="DE-BE"/>
          <postalCode value="10178"/>
          <country value="DE"/>
        </address>
      </Patient>
    </resource>
    <request>
      <method value="PUT"/>
      <url value="Patient/mii-exa-molgen-patient"/>
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  </entry>
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    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/example-mii-molgen-practitioner-lab"/>
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      <Practitioner>
        <id value="mii-exa-molgen-practitioner-lab"/>
        <language value="de"/>
        <text>
          <status value="generated"/>
        </text>
        <active value="true"/>
        <name>
          <use value="official"/>
          <text value="Dr. Daniel Schmidt"/>
          <family value="Schmidt"/>
          <given value="Daniel"/>
          <prefix value="Dr."/>
        </name>
      </Practitioner>
    </resource>
    <request>
      <method value="PUT"/>
      <url value="Practitioner/mii-exa-molgen-practitioner-lab"/>
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  </entry>
  <entry>
    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/example-mii-molgen-specimen-1"/>
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      <Specimen>
        <id value="mii-exa-molgen-specimen-1"/>
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          <profile value="https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore"/>
        </meta>
        <language value="de"/>
        <text>
          <status value="generated"/>
        </text>
        <identifier>
          <system value="https://biobank.uk-musterstadt.de/fhir/sid/proben"/>
          <value value="5432"/>
        </identifier>
        <status value="available"/>
        <type>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="128159001"/>
            <display value="Tissue specimen from colon (specimen)"/>
          </coding>
        </type>
        <subject>
          <reference value="Patient/mii-exa-molgen-patient"/>
        </subject>
        <collection>
          <collectedDateTime value="2022-03-24T12:44:00+01:00"/>
          <bodySite>
            <coding>
              <system value="http://snomed.info/sct"/>
              <code value="71854001"/>
              <display value="Colon structure (body structure)"/>
            </coding>
          </bodySite>
        </collection>
      </Specimen>
    </resource>
    <request>
      <method value="PUT"/>
      <url value="Specimen/mii-exa-molgen-specimen-1"/>
    </request>
  </entry>
  <entry>
    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/mii-exa-molgen-diagnostische-implikation-1"/>
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      <Observation>
        <id value="mii-exa-molgen-diagnostische-implikation-1"/>
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          <profile value="https://www.medizininformatik-initiative.de/fhir/ext/modul-molgen/StructureDefinition/diagnostische-implikation|2027.0.0-ballot.1"/>
          <profile value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication|3.0.0"/>
        </meta>
        <language value="de"/>
        <text>
          <status value="generated"/>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
            <display value="Laboratory"/>
          </coding>
        </category>
        <category>
          <coding>
            <system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
            <code value="GE"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
            <code value="diagnostic-implication"/>
            <display value="Diagnostic Implication"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/mii-exa-molgen-patient"/>
        </subject>
        <effectiveDateTime value="2022-04-07"/>
        <performer>
          <reference value="Practitioner/mii-exa-molgen-practitioner-lab"/>
        </performer>
        <derivedFrom>
          <reference value="Observation/mii-exa-molgen-variante-1"/>
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        <component>
          <code>
            <coding>
              <system value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
              <code value="conclusion-string"/>
            </coding>
          </code>
          <valueString value="Nachweis einer aktivierenden Mutation BRAF V600E"/>
        </component>
      </Observation>
    </resource>
    <request>
      <method value="PUT"/>
      <url value="Observation/mii-exa-molgen-diagnostische-implikation-1"/>
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  </entry>
  <entry>
    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/mii-exa-molgen-therapeutische-implikation-1"/>
    <resource>
      <Observation>
        <id value="mii-exa-molgen-therapeutische-implikation-1"/>
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          <profile value="https://www.medizininformatik-initiative.de/fhir/ext/modul-molgen/StructureDefinition/therapeutische-implikation|2027.0.0-ballot.1"/>
          <profile value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication|3.0.0"/>
        </meta>
        <language value="de"/>
        <text>
          <status value="generated"/>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
            <display value="Laboratory"/>
          </coding>
        </category>
        <category>
          <coding>
            <system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
            <code value="GE"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
            <code value="therapeutic-implication"/>
            <display value="Therapeutic Implication"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/mii-exa-molgen-patient"/>
        </subject>
        <effectiveDateTime value="2022-04-07"/>
        <performer>
          <reference value="Practitioner/mii-exa-molgen-practitioner-lab"/>
        </performer>
        <derivedFrom>
          <reference value="Observation/mii-exa-molgen-variante-1"/>
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        <component>
          <code>
            <coding>
              <system value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
              <code value="conclusion-string"/>
            </coding>
          </code>
          <valueString value="Nachweis einer aktivierenden Mutation BRAF V600E. Triple-Therapie mit einem EGFR-Antikörper sowie einem BRAF- und einem MEK- Inhibitor prüfen."/>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="51963-7"/>
              <display value="Medication assessed [ID]"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.whocc.no/atc"/>
              <code value="L01EC"/>
              <display value="B-Raf serine-threonine kinase (BRAF) inhibitors"/>
            </coding>
            <coding>
              <system value="http://snomed.info/sct"/>
              <code value="703645005"/>
              <display value="Product containing B-Raf inhibitor (product)"/>
            </coding>
            <text value="BRAF Inhibitor"/>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="51963-7"/>
              <display value="Medication assessed [ID]"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.whocc.no/atc"/>
              <code value="L01FE"/>
              <display value="EGFR (Epidermal Growth Factor Receptor) inhibitors"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="51963-7"/>
              <display value="Medication assessed [ID]"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.whocc.no/atc"/>
              <code value="L01EE"/>
              <display value="Mitogen-activated protein kinase (MEK) inhibitors"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
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      <method value="PUT"/>
      <url value="Observation/mii-exa-molgen-therapeutische-implikation-1"/>
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  </entry>
  <entry>
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    <resource>
      <Observation>
        <id value="mii-exa-molgen-variante-1"/>
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          <profile value="https://www.medizininformatik-initiative.de/fhir/ext/modul-molgen/StructureDefinition/variante|2027.0.0-ballot.1"/>
          <profile value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant|3.0.0"/>
        </meta>
        <language value="de"/>
        <text>
          <status value="generated"/>
        </text>
        <basedOn>
          <reference value="ServiceRequest/mii-exa-molgen-anforderung-1"/>
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        <status value="final"/>
        <category>
          <coding>
            <system value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
            <display value="Laboratory"/>
          </coding>
        </category>
        <category>
          <coding>
            <system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
            <code value="GE"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="69548-6"/>
            <display value="Genetic variant assessment"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/mii-exa-molgen-patient"/>
        </subject>
        <effectiveDateTime value="2022-04-07"/>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA9633-4"/>
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          <coding>
            <system value="http://loinc.org"/>
            <code value="LA26398-0"/>
            <display value="Sequencing"/>
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        </method>
        <specimen>
          <reference value="Specimen/mii-exa-molgen-specimen-1"/>
        </specimen>
        <device>
          <reference value="Device/mii-exa-molgen-device-sequencer"/>
        </device>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48018-6"/>
              <display value="Gene studied [ID]"/>
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          <valueCodeableConcept>
            <coding>
              <system value="http://www.genenames.org/geneId"/>
              <code value="HGNC:1097"/>
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        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48013-7"/>
              <display value="Genomic reference sequence [ID]"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.ncbi.nlm.nih.gov/refseq"/>
              <code value="NM_004333.4"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="47999-8"/>
              <display value="DNA region name [Identifier]"/>
            </coding>
          </code>
          <valueString value="Exon #15"/>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="47999-8"/>
              <display value="DNA region name [Identifier]"/>
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          </code>
          <valueString value="Codon #582 - #612"/>
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        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48004-6"/>
              <display value="DNA change (c.HGVS)"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://varnomen.hgvs.org"/>
              <code value="NM_004333.4:c.1799T&gt;A"/>
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          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48005-3"/>
              <display value="Amino acid change (pHGVS)"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://varnomen.hgvs.org"/>
              <code value="p.(Val600Glu)"/>
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          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="81258-6"/>
              <display value="Sample variant allelic frequency [NFr]"/>
            </coding>
          </code>
          <valueQuantity>
            <value value="30.25"/>
            <system value="http://unitsofmeasure.org"/>
            <code value="%"/>
          </valueQuantity>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48001-2"/>
              <display value="Cytogenetic (chromosome) location"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="urn:oid:2.16.840.1.113883.6.335"/>
              <code value="7q34"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48019-4"/>
              <display value="DNA change type"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://sequenceontology.org"/>
              <code value="SO:1000008"/>
              <display value="point_mutation"/>
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          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="81252-9"/>
              <display value="Discrete genetic variant"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.ncbi.nlm.nih.gov/projects/SNP"/>
              <code value="rs113488022"/>
            </coding>
          </valueCodeableConcept>
        </component>
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    </resource>
    <request>
      <method value="PUT"/>
      <url value="Observation/mii-exa-molgen-variante-1"/>
    </request>
  </entry>
  <entry>
    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/mii-exa-molgen-genotyp-1"/>
    <resource>
      <Observation>
        <id value="mii-exa-molgen-genotyp-1"/>
        <meta>
          <profile value="https://www.medizininformatik-initiative.de/fhir/ext/modul-molgen/StructureDefinition/genotyp|2027.0.0-ballot.1"/>
          <profile value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genotype|3.0.0"/>
        </meta>
        <language value="de"/>
        <text>
          <status value="generated"/>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
            <display value="Laboratory"/>
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        </category>
        <category>
          <coding>
            <system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
            <code value="GE"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="84413-4"/>
            <display value="Genotype display name"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/mii-exa-molgen-patient"/>
        </subject>
        <effectiveDateTime value="2022-04-07"/>
        <valueCodeableConcept>
          <text value="BRAF rs113488022 T&gt;A"/>
        </valueCodeableConcept>
        <method>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA26398-0"/>
            <display value="Sequencing"/>
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        </method>
        <specimen>
          <reference value="Specimen/mii-exa-molgen-specimen-1"/>
        </specimen>
        <device>
          <reference value="Device/mii-exa-molgen-device-sequencer"/>
        </device>
        <derivedFrom>
          <reference value="Observation/mii-exa-molgen-variante-1"/>
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        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48018-6"/>
              <display value="Gene studied [ID]"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.genenames.org/geneId"/>
              <code value="HGNC:1097"/>
              <display value="BRAF"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48001-2"/>
              <display value="Cytogenetic (chromosome) location"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="urn:oid:2.16.840.1.113883.6.335"/>
              <code value="7q34"/>
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          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
    <request>
      <method value="PUT"/>
      <url value="Observation/mii-exa-molgen-genotyp-1"/>
    </request>
  </entry>
  <entry>
    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/mii-exa-molgen-mutationslast-1"/>
    <resource>
      <Observation>
        <id value="mii-exa-molgen-mutationslast-1"/>
        <meta>
          <profile value="https://www.medizininformatik-initiative.de/fhir/ext/modul-molgen/StructureDefinition/mutationslast|2027.0.0-ballot.1"/>
          <profile value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-biomarker|3.0.0"/>
        </meta>
        <language value="de"/>
        <text>
          <status value="generated"/>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
            <display value="Laboratory"/>
          </coding>
        </category>
        <category>
          <coding>
            <system value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
            <code value="biomarker-category"/>
            <display value="A characterization of a given biomarker observation."/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="94076-7"/>
            <display value="Mutations/Megabase [# Ratio] in Tumor"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/mii-exa-molgen-patient"/>
        </subject>
        <performer>
          <reference value="Practitioner/mii-exa-molgen-practitioner-lab"/>
        </performer>
        <valueQuantity>
          <value value="12"/>
          <unit value="Mutations/Megabase"/>
          <system value="http://unitsofmeasure.org"/>
          <code value="1/1000000{Base}"/>
        </valueQuantity>
        <specimen>
          <reference value="Specimen/mii-exa-molgen-specimen-1"/>
        </specimen>
      </Observation>
    </resource>
    <request>
      <method value="PUT"/>
      <url value="Observation/mii-exa-molgen-mutationslast-1"/>
    </request>
  </entry>
  <entry>
    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/mii-exa-molgen-device-sequencer"/>
    <resource>
      <Device>
        <id value="mii-exa-molgen-device-sequencer"/>
        <language value="de"/>
        <text>
          <status value="generated"/>
        </text>
        <status value="active"/>
        <manufacturer value="Illumina"/>
        <deviceName>
          <name value="MiSeq"/>
          <type value="manufacturer-name"/>
        </deviceName>
      </Device>
    </resource>
    <request>
      <method value="PUT"/>
      <url value="Device/mii-exa-molgen-device-sequencer"/>
    </request>
  </entry>
  <entry>
    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/mii-exa-molgen-practitioner-physician"/>
    <resource>
      <Practitioner>
        <id value="mii-exa-molgen-practitioner-physician"/>
        <language value="de"/>
        <text>
          <status value="generated"/>
        </text>
        <active value="true"/>
        <name>
          <use value="official"/>
          <text value="Dr. Linda Rubens"/>
          <family value="Rubens"/>
          <given value="Linda"/>
          <prefix value="Dr."/>
        </name>
      </Practitioner>
    </resource>
    <request>
      <method value="PUT"/>
      <url value="Practitioner/mii-exa-molgen-practitioner-physician"/>
    </request>
  </entry>
  <entry>
    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/mii-exa-molgen-mikrosatelliteninstabilitaet-1"/>
    <resource>
      <Observation>
        <id value="mii-exa-molgen-mikrosatelliteninstabilitaet-1"/>
        <meta>
          <profile value="https://www.medizininformatik-initiative.de/fhir/ext/modul-molgen/StructureDefinition/mikrosatelliteninstabilitaet|2027.0.0-ballot.1"/>
          <profile value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-biomarker|3.0.0"/>
        </meta>
        <language value="de"/>
        <text>
          <status value="generated"/>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
            <display value="Laboratory"/>
          </coding>
        </category>
        <category>
          <coding>
            <system value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
            <code value="biomarker-category"/>
            <display value="A characterization of a given biomarker observation."/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="81695-9"/>
            <display value="Microsatellite instability [Interpretation] in Cancer specimen Qualitative"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/mii-exa-molgen-patient"/>
        </subject>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA14122-8"/>
            <display value="Stable"/>
          </coding>
        </valueCodeableConcept>
        <specimen>
          <reference value="Specimen/mii-exa-molgen-specimen-1"/>
        </specimen>
      </Observation>
    </resource>
    <request>
      <method value="PUT"/>
      <url value="Observation/mii-exa-molgen-mikrosatelliteninstabilitaet-1"/>
    </request>
  </entry>
</Bundle>