MII PR Patho Specimen - MII IG Modul Patho v2027.0.0-ballot

MII IG Modul Patho - Local Development build (v2027.0.0-ballot) built by the FHIR (HL7® FHIR® Standard) Build Tools. See the Directory of published versions

Resource Profile: MII PR Patho Specimen

Official URL: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen				Version: 2027.0.0-ballot
Active as of 2026-09-14				Computable Name: MII_PR_Patho_Specimen

This profile inherits from Profile - Specimen - Bioprobe - Core It is based on the HL7 Domain Analysis Model (HL7_DAM_SPECIMEN_R2_INFORM_2019APR). This model, in particular for pathology, accounts for the role model of specimens, which are both the subject and the product of laboratory processes. The root element (Sample) is clinically obtained specimen material from a patient and corresponds to a Part in the pathology workflow. Child elements are blocks and slides, or a cytological preparation. The child specimens (blocks and slides) should always reference at least their direct parent specimen via the Specimen.parent element.

Specimens are referenced in various profiles. In the "PathologyReport" and in the "individual observations" of the groupers for Macroscopy and Diagnostic Conclusions, the specimens of the accession (Parts) should be referenced; in the "individual observations" of the Microscopy grouper, the specimens of the stained tissue slide level should be referenced.

Examples

Part (clinically obtained specimen): mii-exa-patho-prostate-tru-cut-biopsy-sample

Block (results from macroscopic grossing): mii-exa-patho-prostate-biopsy-block

Slide (sectioning and staining): mii-exa-patho-prostate-biopsy-schnitt-HE

Usages:

You can also check for usages in the FHIR IG Statistics

Formal Views of Profile Content

Description of Profiles, Differentials, Snapshots, and their representations.

Key Elements Table
Differential Table
Snapshot Table
Statistics/References
All

Name	Flags	Card.	Type	Description & Constraints Filter: Bindings Constraints Obligations
Specimen		0..*	MII_PR_Biobank_Specimen_Bioprobe_Core	Sample for analysis
id	SΣ	0..1	id	Logical id of this artifact
meta	SΣ	0..1	Meta	Metadata about the resource
lastUpdated	SΣ	0..1	instant	When the resource version last changed
source	SΣ	0..1	uri	Identifies where the resource comes from
profile	SΣ	0..*	canonical(StructureDefinition)	Profiles this resource claims to conform to
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
text	S	0..1	Narrative	Text summary of the resource, for human interpretation This profile does not constrain the narrative in regard to content, language, or traceability to data elements
Slices for extension				Content/Rules for all slices
extension:feature		0..*	(Complex)	MII EX Biobank Feature R5 URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-Specimen.feature
extension:probenebene	S	0..*	Coding	MII EX Biobank Ebene URL: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/mii-ex-biobank-ebene Binding: MII VS Biobank Probenebene (required)
extension:infektiositaetsstatus	S	0..1	CodeableConcept	MII EX Biobank Infektiositätsstatus URL: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/mii-ex-biobank-infektiositaetsstatus Binding: MII VS Biobank Biosafety-Level Einstufung [SNOMED CT] (required)
extension:focus	S	0..1	Reference(RelatedPerson \| Group \| Device \| Substance \| Location)	Specimen Focus URL: http://hl7.eu/fhir/laboratory/StructureDefinition/specimen-focus
modifierExtension	?!	0..*	Extension	Extensions that cannot be ignored
Slices for identifier	SΣ	1..*	Identifier	Identifier Slice: Unordered, Open by pattern:$this.type
identifier:Placer-ID	SΣ	0..1	Identifier	Placer identifier
use	?!Σ	0..1	code	usual \| official \| temp \| secondary \| old (If known) Binding: IdentifierUse (required): Identifies the purpose for this identifier, if known .
type	SΣ	1..1	CodeableConcept	Description of identifier Binding: Identifier Type Codes (extensible): A coded type for an identifier that can be used to determine which identifier to use for a specific purpose. Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
text		0..1	string	Plain text representation of the concept
coding	SΣ	0..*	Coding	Code defined by a terminology system Fixed Value: (Complex)
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
version		0..1	string	Version of the system - if relevant
display		0..1	string	Representation defined by the system
userSelected		0..1	boolean	If this coding was chosen directly by the user
system	SΣ	1..1	uri	Identity of the terminology system Fixed Value: http://terminology.hl7.org/CodeSystem/v2-0203
code	SΣ	1..1	code	Symbol in syntax defined by the system Fixed Value: PLAC
system	SΣ	1..1	uri	The namespace for the identifier value Example General: http://www.acme.com/identifiers/patient
value	SΣ	1..1	string	The value that is unique Example General: 123456
identifier:Filler-ID	SΣ	0..1	Identifier	Filler Identifier
use	?!Σ	0..1	code	usual \| official \| temp \| secondary \| old (If known) Binding: IdentifierUse (required): Identifies the purpose for this identifier, if known .
type	SΣ	1..1	CodeableConcept	Description of identifier Binding: Identifier Type Codes (extensible): A coded type for an identifier that can be used to determine which identifier to use for a specific purpose. Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
text		0..1	string	Plain text representation of the concept
coding	SΣ	0..*	Coding	Code defined by a terminology system Fixed Value: (Complex)
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
version		0..1	string	Version of the system - if relevant
display		0..1	string	Representation defined by the system
userSelected		0..1	boolean	If this coding was chosen directly by the user
system	SΣ	1..1	uri	Identity of the terminology system Fixed Value: http://terminology.hl7.org/CodeSystem/v2-0203
code	SΣ	1..1	code	Symbol in syntax defined by the system Fixed Value: FILL
system	SΣ	1..1	uri	The namespace for the identifier value Example General: http://www.acme.com/identifiers/patient
value	SΣ	1..1	string	The value that is unique Example General: 123456
accessionIdentifier	SΣ	0..1	Identifier	Laboratory ID
status	?!SΣ	1..1	code	Binding: SpecimenStatus (required): Codes providing the status/availability of a specimen.
type	SΣ	1..1	CodeableConcept	Binding: hl7VS-specimenType (example): The type of the specimen.
Slices for coding	Σ	1..*	Coding	Code defined by a terminology system Slice: Unordered, Open by value:$this.system
coding:All Slices				Content/Rules for all slices
system	SΣ	1..1	uri	Identity of the terminology system
code	SΣ	1..1	code	Symbol in syntax defined by the system
coding:sct	SΣ	1..*	Coding	Code defined by a terminology system Binding: MII VS Biobank Probenart SCT (extensible)
system	Σ	0..1	uri	Identity of the terminology system Required Pattern: http://snomed.info/sct
subject	SΣ	1..1	Reference(Patient)
receivedTime	SΣ	0..1	dateTime	The time when specimen was received for processing
parent	S	0..*	Reference(Specimen)
request	S	0..*	Reference(MII PR Patho Service Request)
collection	S	1..1	BackboneElement
Slices for extension				Content/Rules for all slices
extension:einstellungBlutversorgung	S	0..1	dateTime	MII EX Biobank Einstellung Blutversorgung URL: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/EinstellungBlutversorgung
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
collected[x]	SΣ	1..1
collectedDateTime			dateTime
collectedPeriod			Period
quantity	S	0..1	SimpleQuantity(4.0.1)
Slices for extension				Content/Rules for all slices
extension:pqTranslation		0..*	Quantity	Same quantity with different units URL: http://hl7.org/fhir/StructureDefinition/iso21090-PQ-translation
extension:quantityPrecision		0..1	integer	Explicit precision (number of significant decimal places) URL: http://hl7.org/fhir/StructureDefinition/quantity-precision
value	SΣ	1..1	decimal	Numerical value (with implicit precision)
unit	SΣ	1..1	string	Unit representation
system	SΣC	1..1	uri	System that defines coded unit form Required Pattern: http://unitsofmeasure.org
code	SΣ	1..1	code	Coded form of the unit
method	S	1..1	CodeableConcept	Collection method Binding: MII VS Patho Collection Method [SNOMED CT] (extensible)
bodySite	SC	0..1	CodeableConcept	Binding: SNOMEDCTBodyStructures (example): Codes describing anatomical locations. May include laterality. Constraints: mii-bb-1
Slices for extension				Content/Rules for all slices
extension:bodyStructure	S	0..1	(Complex)	Body structure URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-Specimen.collection.bodySite
extension		0..0		Extension Slice: Unordered, Open by value:url Constraints: ext-1
url		1..1	uri	"http://hl7.org/fhir/5.0/StructureDefinition/extension-Specimen.collection.bodySite"
value[x]		0..1	Reference(BodyStructure)	Anatomical collection site
Slices for coding	Σ	0..*	Coding	Code defined by a terminology system Slice: Unordered, Open by value:$this.system
coding:All Slices				Content/Rules for all slices
system	SΣ	1..1	uri	Identity of the terminology system
code	SΣ	1..1	code	Symbol in syntax defined by the system
coding:sct	SΣ	0..*	Coding	Code defined by a terminology system Binding: MII VS Biobank BodyStructures SCT (required)
system	Σ	0..1	uri	Identity of the terminology system Required Pattern: http://snomed.info/sct
coding:icd-o-3	SΣ	0..*	Coding	Code defined by a terminology system Binding: MII VS Onkologie ICD-O-3 Topographie (required)
system	Σ	0..1	uri	Identity of the terminology system Required Pattern: http://terminology.hl7.org/CodeSystem/icd-o-3
Slices for fastingStatus[x]	SΣ	0..1		Slice: Unordered, Open by type:$this Binding: hl7VS-relevantClincialInformation (extensible): Codes describing the fasting status of the patient.
fastingStatusCodeableConcept			CodeableConcept
fastingStatusDuration			Duration
fastingStatus[x]:fastingStatusCodeableConcept	Σ	0..1	CodeableConcept	Whether or how long patient abstained from food and/or drink Binding: hl7VS-relevantClincialInformation (required)
coding	Σ	0..*	Coding	Code defined by a terminology system
system	SΣ	1..1	uri	Identity of the terminology system
code	SΣ	1..1	code	Symbol in syntax defined by the system
Slices for processing	S	0..*	BackboneElement	Slice: Unordered, Open by value:$this.procedure
processing:All Slices				Content/Rules for all slices
Slices for extension				Content/Rules for all slices
extension:temperaturbedingungen	S	0..1	Range	MII EX Biobank Temperaturbedingungen URL: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
procedure	S	1..1	CodeableConcept	Binding: MII VS Patho Processing Procedure [SNOMED CT] (extensible)
Slices for coding	Σ	1..*	Coding	Code defined by a terminology system Slice: Unordered, Open by value:$this.system
coding:All Slices				Content/Rules for all slices
system	SΣ	1..1	uri	Identity of the terminology system
code	SΣ	1..1	code	Symbol in syntax defined by the system
coding:sct	SΣ	1..*	Coding	Code defined by a terminology system Binding: MII VS Biobank Laboratory Procedure SCT (preferred)
system	Σ	0..1	uri	Identity of the terminology system Required Pattern: http://snomed.info/sct
additive	S	0..*	Reference(MII PR Biobank Substance Additiv)
Slices for time[x]	S	0..1		Date and time of specimen processing Slice: Unordered, Open by type:$this
timeDateTime			dateTime
timePeriod			Period
time[x]:timePeriod	S	0..1	Period
start	SΣC	0..1	dateTime	Starting time with inclusive boundary
end	SΣC	0..1	dateTime	End time with inclusive boundary, if not ongoing
processing:lagerprozess	S	0..*	BackboneElement	Processing and processing step details
Slices for extension	S	1..*	Extension	Extension Slice: Unordered, Open by value:url
Slices for extension				Content/Rules for all slices
extension:temperaturbedingungen	S	0..1	Range	MII EX Biobank Temperaturbedingungen URL: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
procedure		1..1	CodeableConcept	Indicates the treatment step applied to the specimen Binding: SpecimenProcessingProcedure (example): Type indicating the technique used to process the specimen. Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
coding		1..*	Coding	Code defined by a terminology system Fixed Value: (Complex)
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
system		1..1	uri	Identity of the terminology system Fixed Value: http://snomed.info/sct
version		0..1	string	Version of the system - if relevant
code		1..1	code	Symbol in syntax defined by the system Fixed Value: 1186936003
display		0..1	string	Representation defined by the system
userSelected		0..1	boolean	If this coding was chosen directly by the user
text		0..1	string	Plain text representation of the concept
additive		0..*	Reference(MII PR Biobank Substance Additiv)	Material used in the processing step
Slices for time[x]		1..1	Period	Date and time of specimen processing Slice: Unordered, Closed by type:$this
Slices for time[x]				Content/Rules for all slices
time[x]:timePeriod		1..1	Period	Date and time of specimen processing
start	ΣC	1..1	dateTime	Starting time with inclusive boundary
container	S	0..*	BackboneElement	Container
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
type	S	1..1	CodeableConcept	Binding: MII VS Patho Container Type [SNOMED CT] (required)
coding	Σ	0..*	Coding	Code defined by a terminology system
system	SΣ	1..1	uri	Identity of the terminology system
code	SΣ	1..1	code	Symbol in syntax defined by the system
capacity	S	0..1	SimpleQuantity(4.0.1)
value	SΣ	1..1	decimal	Numerical value (with implicit precision)
unit	SΣ	1..1	string	Unit representation
system	SΣC	1..1	uri	System that defines coded unit form Required Pattern: http://unitsofmeasure.org
code	SΣ	1..1	code	Coded form of the unit
specimenQuantity	S	0..1	SimpleQuantity(4.0.1)
value	SΣ	1..1	decimal	Numerical value (with implicit precision)
unit	SΣ	1..1	string	Unit representation
system	SΣC	1..1	uri	System that defines coded unit form Required Pattern: http://unitsofmeasure.org
code	SΣ	1..1	code	Coded form of the unit
Slices for additive[x]	S	0..1		Slice: Unordered, Open by type:$this Binding: hl7VS-additivePreservative (example): Substance added to specimen container.
additiveCodeableConcept			CodeableConcept
additiveReference			Reference(Substance)
additive[x]:additiveReference		0..1	Reference(MII PR Biobank Substance Additiv)	Additive associated with container
note	S	0..*	Annotation
Documentation for this format

Terminology Bindings

Path	Status	Usage	ValueSet	Version	Source
Specimen.identifier:Placer-ID.use	Base	required	IdentifierUse	📍4.0.1	FHIR Std.
Specimen.identifier:Placer-ID.type	Base	extensible	IdentifierType	📍4.0.1	FHIR Std.
Specimen.identifier:Filler-ID.use	Base	required	IdentifierUse	📍4.0.1	FHIR Std.
Specimen.identifier:Filler-ID.type	Base	extensible	IdentifierType	📍4.0.1	FHIR Std.
Specimen.status	Base	required	SpecimenStatus	📍4.0.1	FHIR Std.
Specimen.type	Base	example	hl7VS-specimenType	📦3.0.0	THO v7.3
Specimen.type.coding:sct	Base	extensible	MII VS Biobank Probenart SCT	📦2027.0.0-ballot	This IG
Specimen.collection.method	Base	extensible	MII VS Patho Collection Method [SNOMED CT]	📦2027.0.0-ballot	This IG
Specimen.collection.bodySite	Base	example	SNOMED CT Body Structures	📍4.0.1	FHIR Std.
Specimen.collection.bodySite.coding:sct	Base	required	MII VS Biobank BodyStructures SCT	📦2027.0.0-ballot	This IG
Specimen.collection.bodySite.coding:icd-o-3	Base	required	MII VS Onkologie ICD-O-3 Topographie	⏿2025.1.0	127.0.0.1
Specimen.collection.fastingStatus[x]	Base	extensible	hl7VS-relevantClincialInformation	📦3.0.0	THO v7.3
Specimen.collection.fastingStatus[x]:fastingStatusCodeableConcept	Base	required	hl7VS-relevantClincialInformation	📦3.0.0	THO v7.3
Specimen.processing.procedure	Base	extensible	MII VS Patho Processing Procedure [SNOMED CT]	📦2027.0.0-ballot	This IG
Specimen.processing.procedure.coding:sct	Base	preferred	MII VS Biobank Laboratory Procedure SCT	📦2027.0.0-ballot	This IG
Specimen.processing:lagerprozess.procedure	Base	example	Specimen processing procedure	📍4.0.1	FHIR Std.
Specimen.container.type	Base	required	MII VS Patho Container Type [SNOMED CT]	📦2027.0.0-ballot	This IG
Specimen.container.additive[x]	Base	example	hl7VS-additivePreservative	📦3.0.0	THO v7.3

Constraints

Id	Grade	Path(s)	Description	Expression
dom-2	error	Specimen	If the resource is contained in another resource, it SHALL NOT contain nested Resources	`contained.contained.empty()`
dom-3	error	Specimen	If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource	`contained.where((('#'+id in (%resource.descendants().reference \| %resource.descendants().as(canonical) \| %resource.descendants().as(uri) \| %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()`
dom-4	error	Specimen	If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated	`contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()`
dom-5	error	Specimen	If a resource is contained in another resource, it SHALL NOT have a security label	`contained.meta.security.empty()`
dom-6	best practice	Specimen	A resource should have narrative for robust management	text.`div`.exists()
ele-1	error	ALL elements	All FHIR elements must have a @value or children	`hasValue() or (children().count() > id.count())`
ext-1	error	ALL extensions	Must have either extensions or value[x], not both	`extension.exists() != value.exists()`
mii-bb-1	error	Specimen.collection.bodySite	Bei der Angabe der Entnahmestelle muss ein ICD-O-3 Topographiecode oder ein SNOMED CT Code angegeben werden.	`coding.where(system = 'http://snomed.info/sct' or system = 'http://terminology.hl7.org/CodeSystem/icd-o-3').exists()`

Name	Flags	Card.	Type	Description & Constraints Filter: Bindings Constraints Obligations
Specimen			MII_PR_Biobank_Specimen_Bioprobe_Core
meta
lastUpdated	S	0..1	instant	When the resource version last changed
text	S	0..1	Narrative	Text summary of the resource, for human interpretation
Slices for identifier		1..*	Identifier	Identifier Slice: Unordered, Open by pattern:$this.type
identifier:Placer-ID	S	0..1	Identifier	Placer identifier
type	S	1..1	CodeableConcept	Description of identifier Required Pattern: At least the following
coding	S	0..*	Coding	Code defined by a terminology system Fixed Value: (Complex)
system	S	1..1	uri	Identity of the terminology system Fixed Value: http://terminology.hl7.org/CodeSystem/v2-0203
code	S	1..1	code	Symbol in syntax defined by the system Fixed Value: PLAC
system	S	1..1	uri	The namespace for the identifier value
value	S	1..1	string	The value that is unique
identifier:Filler-ID	S	0..1	Identifier	Filler Identifier
type	S	1..1	CodeableConcept	Description of identifier Required Pattern: At least the following
coding	S	0..*	Coding	Code defined by a terminology system Fixed Value: (Complex)
system	S	1..1	uri	Identity of the terminology system Fixed Value: http://terminology.hl7.org/CodeSystem/v2-0203
code	S	1..1	code	Symbol in syntax defined by the system Fixed Value: FILL
system	S	1..1	uri	The namespace for the identifier value
value	S	1..1	string	The value that is unique
accessionIdentifier	S	0..1	Identifier	Laboratory ID
request		0..*	Reference(MII PR Patho Service Request)
collection
method	S	1..1	CodeableConcept	Collection method Binding: MII VS Patho Collection Method [SNOMED CT] (extensible)
bodySite
Slices for extension				Content/Rules for all slices
extension:bodyStructure	S	0..1	(Complex)	Body structure URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-Specimen.collection.bodySite
extension		0..0		Extension
value[x]		0..1	Reference(BodyStructure)	Anatomical collection site
processing		0..*	BackboneElement
procedure		1..1	CodeableConcept	Binding: MII VS Patho Processing Procedure [SNOMED CT] (extensible)
Slices for processing				Content/Rules for all slices
processing:lagerprozess		0..*	BackboneElement	Processing and processing step details
additive		0..*	Reference(MII PR Biobank Substance Additiv)	Material used in the processing step
container		0..*	BackboneElement	Container
type		1..1	CodeableConcept	Binding: MII VS Patho Container Type [SNOMED CT] (required)
Documentation for this format

Terminology Bindings (Differential)

Path	Status	Usage	ValueSet	Version	Source
Specimen.collection.method	Base	extensible	MII VS Patho Collection Method [SNOMED CT]	📦2027.0.0-ballot	This IG
Specimen.processing.procedure	Base	extensible	MII VS Patho Processing Procedure [SNOMED CT]	📦2027.0.0-ballot	This IG
Specimen.container.type	Base	required	MII VS Patho Container Type [SNOMED CT]	📦2027.0.0-ballot	This IG

Description & Constraints Filter: Filters

Specimen

0..*

MII_PR_Biobank_Specimen_Bioprobe_Core

Sample for analysis

SΣ

0..1

Logical id of this artifact

Meta

Metadata about the resource

0..1