{
  "resourceType" : "Specimen",
  "id" : "OrganoidLunge",
  "meta" : {
    "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/mii-pr-biobank-zellinie-organoid"]
  },
  "language" : "de",
  "text" : {
    "status" : "extensions",
    "div" : "<div xml:lang=\"de\" lang=\"de\"><hr/><p><b>German</b></p><hr/><p class=\"res-header-id\"><b>Generated Narrative: Specimen OrganoidLunge</b></p><a name=\"de-OrganoidLunge\"> </a><a name=\"de-hcOrganoidLunge\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-mii-pr-biobank-zellinie-organoid.html\">MII PR Biobank Specimen Zellinie Organoid</a></p></div><p><b>MII EX Biobank Kulturprotokoll</b>: <a href=\"DocumentReference-Kulturprotokoll.html\">DocumentReference: status = current; date = 2018-06-20 09:00:00+0100; description = Standardprotokoll zur Kultivierung von Lungentumor-Organoiden</a></p><blockquote><p><b>MII EX Biobank Zelllinien-Modifikation</b></p><ul><li>artDerModifikation: <span title=\"Codes:{http://purl.obolibrary.org/obo/clo.owl CLO:0037375}\">derives from cell with knockout gene</span></li><li>zielGen: <a href=\"http://terminology.hl7.org/6.3.0/CodeSystem-v3-hgnc.html#v3-hgnc-TP53\">HUGO Gene Nomenclature Committee Genes: TP53</a> (tumor protein p53)</li><li>protokoll: <a href=\"DocumentReference-ProtocolCRISPRTP53.html\">DocumentReference: status = current; date = 2018-06-19 09:00:00+0100; description = CRISPR Knockout-Protokoll für TP53 in Lungentumor-Organoiden</a></li></ul></blockquote><p><b>MII EX Biobank Anzahl Passagen</b>: 3</p><p><b>identifier</b>: <code>https://biobank.uk-musterstadt.de/fhir/sid/proben</code>/6789-ORG-1</p><p><b>status</b>: Available</p><p><b>type</b>: <span title=\"Codes:{http://snomed.info/sct 123038009}, {https://fhir.bbmri-eric.eu/CodeSystem/miabis-detailed-samply-type-cs Organoid}\">Specimen (specimen)</span></p><p><b>subject</b>: <a href=\"https://simplifier.net/resolve?scope=de.basisprofil.r4@1.6.0&amp;canonical=http://fhir.org/packages/de.basisprofil.r4/Patient/mii-exa-test-data-patient-1\">Patient/mii-exa-test-data-patient-1</a></p><p><b>parent</b>: </p><p><b style=\"color: maroon\">Exception Generating Narrative: Cannot invoke &quot;org.hl7.fhir.r5.renderers.utils.ResourceWrapper.fhirType()&quot; because &quot;resource&quot; is null </b></p></div>"
  },
  "extension" : [{
    "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/mii-ex-biobank-kulturprotokoll",
    "valueReference" : {
      "reference" : "DocumentReference/Kulturprotokoll"
    }
  },
  {
    "extension" : [{
      "url" : "artDerModifikation",
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://purl.obolibrary.org/obo/clo.owl",
          "code" : "CLO:0037375",
          "display" : "derives from cell with knockout gene"
        }]
      }
    },
    {
      "url" : "zielGen",
      "valueCoding" : {
        "system" : "http://www.genenames.org",
        "code" : "TP53",
        "display" : "tumor protein p53"
      }
    },
    {
      "url" : "protokoll",
      "valueReference" : {
        "reference" : "DocumentReference/ProtocolCRISPRTP53"
      }
    }],
    "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/mii-ex-biobank-modifikationen"
  },
  {
    "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/mii-ex-biobank-anzahl-passagen",
    "valueInteger" : 3
  }],
  "identifier" : [{
    "system" : "https://biobank.uk-musterstadt.de/fhir/sid/proben",
    "value" : "6789-ORG-1"
  }],
  "status" : "available",
  "type" : {
    "coding" : [{
      "system" : "http://snomed.info/sct",
      "code" : "123038009",
      "display" : "Specimen (specimen)"
    },
    {
      "system" : "https://fhir.bbmri-eric.eu/CodeSystem/miabis-detailed-samply-type-cs",
      "code" : "Organoid",
      "display" : "Organoids"
    }]
  },
  "subject" : {
    "reference" : "Patient/mii-exa-test-data-patient-1"
  },
  "parent" : [{
    "reference" : "Specimen/MusterprobeGewebe"
  }],
  "collection" : {
    "collectedDateTime" : "2018-06-08T15:34:00+01:00"
  },
  "processing" : [{
    "extension" : [{
      "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen",
      "valueRange" : {
        "low" : {
          "value" : 37,
          "unit" : "°C",
          "system" : "http://unitsofmeasure.org",
          "code" : "Cel"
        },
        "high" : {
          "value" : 37,
          "unit" : "°C",
          "system" : "http://unitsofmeasure.org",
          "code" : "Cel"
        }
      }
    }],
    "procedure" : {
      "coding" : [{
        "system" : "http://snomed.info/sct",
        "code" : "1186936003",
        "display" : "Storage of specimen (procedure)"
      }]
    },
    "timePeriod" : {
      "start" : "2018-06-20T10:00:00+01:00",
      "end" : "2018-06-27T10:00:00+01:00"
    }
  }],
  "container" : [{
    "type" : {
      "coding" : [{
        "system" : "http://snomed.info/sct",
        "code" : "83059008",
        "display" : "Tube, device (physical object)"
      }]
    },
    "specimenQuantity" : {
      "value" : 1,
      "unit" : "ml",
      "system" : "http://unitsofmeasure.org",
      "code" : "ml"
    }
  }]
}