{
  "resourceType" : "Bundle",
  "id" : "mii-exa-mtb-kim-musterperson-bundle",
  "language" : "de",
  "type" : "transaction",
  "entry" : [{
    "fullUrl" : "http://example.org/fhir/ClinicalImpression/mii-exa-mtb-kim-musterperson-behandlungsepisode",
    "resource" : {
      "resourceType" : "ClinicalImpression",
      "id" : "mii-exa-mtb-kim-musterperson-behandlungsepisode",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-behandlungsepisode|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "completed",
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectivePeriod" : {
        "start" : "2023-01-20",
        "end" : "2023-03-28"
      },
      "problem" : [{
        "reference" : "Condition/mii-exa-mtb-kim-diagnose"
      }],
      "investigation" : [{
        "code" : {
          "coding" : [{
            "system" : "http://snomed.info/sct",
            "code" : "106221001",
            "display" : "Genetic finding"
          }]
        },
        "item" : [{
          "reference" : "DiagnosticReport/mii-exa-mtb-kim-musterperson-ngs-bericht"
        }]
      },
      {
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "60568-3",
            "display" : "Pathology synoptic report"
          }]
        },
        "item" : [{
          "reference" : "DiagnosticReport/PatientKimMusterperson-MolecularPathologyReport-1"
        }]
      },
      {
        "code" : {
          "coding" : [{
            "system" : "http://snomed.info/sct",
            "code" : "424122007",
            "display" : "ECOG performance status finding"
          }]
        },
        "item" : [{
          "reference" : "Observation/mii-exa-onko-allgemeiner-leistungszustand-ecog"
        }]
      },
      {
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "105511-0",
            "display" : "Was consent given"
          }]
        },
        "item" : [{
          "reference" : "Observation/mii-exa-mtb-kim-musterperson-aufklaerung"
        }]
      }],
      "supportingInfo" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-1"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-1"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-2"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-3"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-4"
      },
      {
        "reference" : "Procedure/PatientKimMusterperson-Procedure-2"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-5"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-6"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-7"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-8"
      },
      {
        "reference" : "Procedure/PatientKimMusterperson-Procedure-3"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-9"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-10"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-11"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-12"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-13"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-14"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-15"
      },
      {
        "reference" : "Procedure/PatientKimMusterperson-Procedure-4"
      },
      {
        "reference" : "Procedure/PatientKimMusterperson-Procedure-4a"
      },
      {
        "reference" : "Procedure/PatientKimMusterperson-Procedure-4b"
      },
      {
        "reference" : "Procedure/PatientKimMusterperson-Procedure-4c"
      },
      {
        "reference" : "Procedure/PatientKimMusterperson-Procedure-4d"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-16"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-17"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-18"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-19"
      },
      {
        "reference" : "Procedure/PatientKimMusterperson-SystemicTherapy-1"
      },
      {
        "reference" : "Procedure/PatientKimMusterperson-SystemicTherapy-2"
      },
      {
        "reference" : "Procedure/PatientKimMusterperson-SystemicTherapy-3"
      },
      {
        "reference" : "Procedure/MTBChemo1Procedure"
      },
      {
        "reference" : "Procedure/PatientKimMusterperson-Procedure-5"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-20"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-21"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-22"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-23"
      },
      {
        "reference" : "Procedure/MTBChemo2Procedure"
      },
      {
        "reference" : "Procedure/PatientKimMusterperson-Procedure-6"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-24"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-25"
      },
      {
        "reference" : "Procedure/PatientKimMusterperson-Procedure-7"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-26"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-27"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-29"
      },
      {
        "reference" : "Observation/PatientKimMusterperson-Observation-30"
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "ClinicalImpression/mii-exa-mtb-kim-musterperson-behandlungsepisode"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/mii-exa-mtb-kim-musterperson-aufklaerung",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "mii-exa-mtb-kim-musterperson-aufklaerung",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-consent-given|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "105511-0",
          "display" : "Was consent given"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-01-02",
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "373066001",
          "display" : "Yes (qualifier value)"
        }]
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/mii-exa-mtb-kim-musterperson-aufklaerung"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Patient/PatientKimMusterperson",
    "resource" : {
      "resourceType" : "Patient",
      "id" : "PatientKimMusterperson",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "name" : [{
        "family" : "Musterperson",
        "given" : ["Kim"]
      }],
      "birthDate" : "1956-03-14"
    },
    "request" : {
      "method" : "PUT",
      "url" : "Patient/PatientKimMusterperson"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/MTBObservationCA125-1",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "MTBObservationCA125-1",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "26436-6",
          "display" : "Laboratory studies (set)"
        }]
      },
      {
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "11210-2",
          "display" : "Cancer Ag 125 [Units/volume] in Body fluid"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2022-04-22",
      "valueQuantity" : {
        "value" : 42.3,
        "unit" : "IU/ml",
        "system" : "http://unitsofmeasure.org",
        "code" : "[iU]/ml"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/MTBObservationCA125-1"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/MTBObservationCA125-2",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "MTBObservationCA125-2",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "26436-6",
          "display" : "Laboratory studies (set)"
        }]
      },
      {
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "11210-2",
          "display" : "Cancer Ag 125 [Units/volume] in Body fluid"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2022-07-18",
      "valueQuantity" : {
        "value" : 45.8,
        "unit" : "IU/ml",
        "system" : "http://unitsofmeasure.org",
        "code" : "[iU]/ml"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/MTBObservationCA125-2"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/MTBObservationCA125-3",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "MTBObservationCA125-3",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "26436-6",
          "display" : "Laboratory studies (set)"
        }]
      },
      {
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "11210-2",
          "display" : "Cancer Ag 125 [Units/volume] in Body fluid"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2022-10-24",
      "valueQuantity" : {
        "value" : 49.7,
        "unit" : "IU/ml",
        "system" : "http://unitsofmeasure.org",
        "code" : "[iU]/ml"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/MTBObservationCA125-3"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/MTBObservationCA125-4",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "MTBObservationCA125-4",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "26436-6",
          "display" : "Laboratory studies (set)"
        }]
      },
      {
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "11210-2",
          "display" : "Cancer Ag 125 [Units/volume] in Body fluid"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2022-12-27",
      "valueQuantity" : {
        "value" : 67.2,
        "unit" : "IU/ml",
        "system" : "http://unitsofmeasure.org",
        "code" : "[iU]/ml"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/MTBObservationCA125-4"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/MTBObservationCA125-5",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "MTBObservationCA125-5",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "26436-6",
          "display" : "Laboratory studies (set)"
        }]
      },
      {
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "11210-2",
          "display" : "Cancer Ag 125 [Units/volume] in Body fluid"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-03-24",
      "valueQuantity" : {
        "value" : 43.7,
        "unit" : "IU/ml",
        "system" : "http://unitsofmeasure.org",
        "code" : "[iU]/ml"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/MTBObservationCA125-5"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/MTBObservationCA125-6",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "MTBObservationCA125-6",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "26436-6",
          "display" : "Laboratory studies (set)"
        }]
      },
      {
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "11210-2",
          "display" : "Cancer Ag 125 [Units/volume] in Body fluid"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-06-20",
      "valueQuantity" : {
        "value" : 78.2,
        "unit" : "IU/ml",
        "system" : "http://unitsofmeasure.org",
        "code" : "[iU]/ml"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/MTBObservationCA125-6"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/DiagnosticReport/PatientKimMusterperson-MolecularPathologyReport-1",
    "resource" : {
      "resourceType" : "DiagnosticReport",
      "id" : "PatientKimMusterperson-MolecularPathologyReport-1",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-molecular-pathology-report|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "60568-3",
          "display" : "Pathology synoptic report"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "result" : [{
        "reference" : "Observation/PatientKimMusterperson-MolecularPathologyObservation-0a-Her2neu"
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "DiagnosticReport/PatientKimMusterperson-MolecularPathologyReport-1"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Specimen/PatientKimMusterperson-AscitesSpecimen-2",
    "resource" : {
      "resourceType" : "Specimen",
      "id" : "PatientKimMusterperson-AscitesSpecimen-2",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-specimen"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "accessionIdentifier" : {
        "value" : "Z230201/23"
      },
      "type" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "309201001",
          "display" : "Ascitic fluid specimen (specimen)"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "collection" : {
        "collectedDateTime" : "2023-02-01"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-0a-Her2neu",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-MolecularPathologyObservation-0a-Her2neu",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }]
      },
      {
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
          "code" : "GE"
        }]
      },
      {
        "coding" : [{
          "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
          "code" : "biomarker-category"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "18474-7",
          "display" : "HER2 Ag [Presence] in Tissue by Immune stain"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "1234806008",
          "display" : "Observation using immunohistochemistry (observable entity)"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "LA11842-4",
          "display" : "2+"
        }]
      },
      "specimen" : {
        "reference" : "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
      },
      "component" : [{
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "48018-6",
            "display" : "Gene studied [ID]"
          }]
        },
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://www.genenames.org/geneId",
            "code" : "HGNC:3430",
            "display" : "ERBB2"
          }]
        }
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-MolecularPathologyObservation-0a-Her2neu"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyInterpret-0a-Her2neu",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-MolecularPathologyInterpret-0a-Her2neu",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }]
      },
      {
        "coding" : [{
          "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
          "code" : "biomarker-category"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "48676-1",
          "display" : "HER2 Ag [Interpretation] in Tissue"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "1234806008",
          "display" : "Observation using immunohistochemistry (observable entity)"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "1381317004",
          "display" : "Human epidermal growth factor receptor 2 low"
        }],
        "text" : "HER2-low (IHC 2+/ISH negative)"
      },
      "specimen" : {
        "reference" : "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
      },
      "component" : [{
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "48018-6",
            "display" : "Gene studied [ID]"
          }]
        },
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://www.genenames.org/geneId",
            "code" : "HGNC:3430",
            "display" : "ERBB2"
          }]
        }
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-MolecularPathologyInterpret-0a-Her2neu"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-0b-Folat-Ra",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-MolecularPathologyObservation-0b-Folat-Ra",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }]
      },
      {
        "coding" : [{
          "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
          "code" : "biomarker-category"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "55229-9",
          "display" : "Immune stain study"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "1234806008",
          "display" : "Observation using immunohistochemistry (observable entity)"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "valueQuantity" : {
        "value" : 70,
        "unit" : "%",
        "system" : "http://unitsofmeasure.org",
        "code" : "{/100}"
      },
      "specimen" : {
        "reference" : "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
      },
      "component" : [{
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "48018-6",
            "display" : "Gene studied [ID]"
          }]
        },
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://www.genenames.org/geneId",
            "code" : "HGNC:3791",
            "display" : "FOLR1"
          },
          {
            "system" : "http://loinc.org",
            "code" : "LP440974-6",
            "display" : "Folate receptor alpha"
          }]
        }
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-MolecularPathologyObservation-0b-Folat-Ra"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-0c-Trop2",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-MolecularPathologyObservation-0c-Trop2",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }]
      },
      {
        "coding" : [{
          "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
          "code" : "biomarker-category"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "55229-9",
          "display" : "Immune stain study"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "1234806008",
          "display" : "Observation using immunohistochemistry (observable entity)"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "LA6576-8",
          "display" : "Positive"
        }]
      },
      "specimen" : {
        "reference" : "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
      },
      "component" : [{
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "48018-6",
            "display" : "Gene studied [ID]"
          }]
        },
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://www.genenames.org/geneId",
            "code" : "HGNC:11530",
            "display" : "TACSTD2"
          },
          {
            "system" : "http://www.uniprot.org",
            "code" : "P09758",
            "display" : "Tumor-associated calcium signal transducer 2"
          }]
        }
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-MolecularPathologyObservation-0c-Trop2"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-1-CA125",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-MolecularPathologyObservation-1-CA125",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }]
      },
      {
        "coding" : [{
          "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
          "code" : "biomarker-category"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "48677-9",
          "display" : "Cancer Ag 125 [Presence] in Tissue by Immune stain"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "1234806008",
          "display" : "Observation using immunohistochemistry (observable entity)"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "LA6576-8",
          "display" : "Positive"
        }],
        "text" : "Die Tumorzellen sind partiell positiv für CA125,..."
      },
      "specimen" : {
        "reference" : "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
      },
      "component" : [{
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "48018-6",
            "display" : "Gene studied [ID]"
          }]
        },
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://www.genenames.org/geneId",
            "code" : "HGNC:11530",
            "display" : "TACSTD2"
          },
          {
            "system" : "http://www.uniprot.org",
            "code" : "P09758",
            "display" : "Tumor-associated calcium signal transducer 2"
          }]
        }
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-MolecularPathologyObservation-1-CA125"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-2-Pax8",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-MolecularPathologyObservation-2-Pax8",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }]
      },
      {
        "coding" : [{
          "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
          "code" : "biomarker-category"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "73910-2",
          "display" : "PAX8 Ag [Presence] in Tissue by Immune stain"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "1234806008",
          "display" : "Observation using immunohistochemistry (observable entity)"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "LA6576-8",
          "display" : "Positive"
        }],
        "text" : "Tumorzellen durchgehend nukleär für Pax 8"
      },
      "specimen" : {
        "reference" : "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-MolecularPathologyObservation-2-Pax8"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-3-WT1",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-MolecularPathologyObservation-3-WT1",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }]
      },
      {
        "coding" : [{
          "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
          "code" : "biomarker-category"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "1234806008",
          "display" : "Observation using immunohistochemistry (observable entity)"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "LA6576-8",
          "display" : "Positive"
        }],
        "text" : "Tumorzellen durchgehend nukleär für WT1"
      },
      "bodySite" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "84640000",
          "display" : "Nucleus (cell structure)"
        }],
        "text" : "Nukleär"
      },
      "specimen" : {
        "reference" : "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
      },
      "component" : [{
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "48018-6",
            "display" : "Gene studied [ID]"
          }]
        },
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://www.genenames.org/geneId",
            "code" : "HGNC:12796",
            "display" : "WT1"
          },
          {
            "system" : "http://loinc.org",
            "code" : "LP65352-4",
            "display" : "WT-1 Ag"
          }]
        }
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-MolecularPathologyObservation-3-WT1"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-4-ER",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-MolecularPathologyObservation-4-ER",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }]
      },
      {
        "coding" : [{
          "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
          "code" : "biomarker-category"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "14228-1",
          "display" : "Cells.estrogen receptor/cells in Tissue by Immune stain"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "1234806008",
          "display" : "Observation using immunohistochemistry (observable entity)"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "valueQuantity" : {
        "value" : 70,
        "unit" : "%",
        "system" : "http://unitsofmeasure.org",
        "code" : "/100"
      },
      "specimen" : {
        "reference" : "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-MolecularPathologyObservation-4-ER"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-5-PR",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-MolecularPathologyObservation-5-PR",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }]
      },
      {
        "coding" : [{
          "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
          "code" : "biomarker-category"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "14230-7",
          "display" : "Cells.progesterone receptor/cells in Tissue by Immune stain"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "1234806008",
          "display" : "Observation using immunohistochemistry (observable entity)"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "valueQuantity" : {
        "value" : 30,
        "unit" : "%",
        "system" : "http://unitsofmeasure.org",
        "code" : "/100"
      },
      "specimen" : {
        "reference" : "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-MolecularPathologyObservation-5-PR"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-6-p53",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-MolecularPathologyObservation-6-p53",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }]
      },
      {
        "coding" : [{
          "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
          "code" : "biomarker-category"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "14229-9",
          "display" : "P53 protein Ag [Presence] in Tissue by Immune stain"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "1234806008",
          "display" : "Observation using immunohistochemistry (observable entity)"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "LA6576-8",
          "display" : "Positive"
        }],
        "text" : "Kräftige nukleäre Überexpression von p53"
      },
      "specimen" : {
        "reference" : "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-MolecularPathologyObservation-6-p53"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-7-p53",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-MolecularPathologyObservation-7-p53",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }]
      },
      {
        "coding" : [{
          "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
          "code" : "biomarker-category"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "14229-9",
          "display" : "P53 protein Ag [Presence] in Tissue by Immune stain"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "1234806008",
          "display" : "Observation using immunohistochemistry (observable entity)"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "LA6576-8",
          "display" : "Positive"
        }],
        "text" : "Kräftige nukleäre Überexpression von p53"
      },
      "specimen" : {
        "reference" : "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-MolecularPathologyObservation-7-p53"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Procedure/PatientKimMusterperson-Procedure-1",
    "resource" : {
      "resourceType" : "Procedure",
      "id" : "PatientKimMusterperson-Procedure-1",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/core/modul-prozedur/StructureDefinition/Procedure"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "completed",
      "category" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "363680008",
          "display" : "Radiographic imaging procedure"
        }]
      },
      "code" : {
        "coding" : [{
          "system" : "http://fhir.de/CodeSystem/bfarm/ops",
          "version" : "2025",
          "code" : "3-20",
          "display" : "Computertomographie [CT], nativ"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "performedDateTime" : "2022-04-20",
      "bodySite" : [{
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "818983003",
          "display" : "Abdomen"
        }]
      },
      {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "51185008",
          "display" : "Thoracic structure"
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "Procedure/PatientKimMusterperson-Procedure-1"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Procedure/PatientKimMusterperson-Procedure-2",
    "resource" : {
      "resourceType" : "Procedure",
      "id" : "PatientKimMusterperson-Procedure-2",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/core/modul-prozedur/StructureDefinition/Procedure"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "completed",
      "category" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "363680008",
          "display" : "Radiographic imaging procedure"
        }]
      },
      "code" : {
        "coding" : [{
          "system" : "http://fhir.de/CodeSystem/bfarm/ops",
          "version" : "2025",
          "code" : "3-20",
          "display" : "Computertomographie [CT], nativ"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "performedDateTime" : "2022-07-15",
      "bodySite" : [{
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "818983003",
          "display" : "Abdomen"
        }]
      },
      {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "51185008",
          "display" : "Thoracic structure"
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "Procedure/PatientKimMusterperson-Procedure-2"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Procedure/PatientKimMusterperson-Procedure-3",
    "resource" : {
      "resourceType" : "Procedure",
      "id" : "PatientKimMusterperson-Procedure-3",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/core/modul-prozedur/StructureDefinition/Procedure"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "completed",
      "category" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "363680008",
          "display" : "Radiographic imaging procedure"
        }]
      },
      "code" : {
        "coding" : [{
          "system" : "http://fhir.de/CodeSystem/bfarm/ops",
          "version" : "2025",
          "code" : "3-20",
          "display" : "Computertomographie [CT], nativ"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "performedDateTime" : "2022-10-22",
      "bodySite" : [{
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "818983003",
          "display" : "Abdomen"
        }]
      },
      {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "51185008",
          "display" : "Thoracic structure"
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "Procedure/PatientKimMusterperson-Procedure-3"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Procedure/PatientKimMusterperson-Procedure-4",
    "resource" : {
      "resourceType" : "Procedure",
      "id" : "PatientKimMusterperson-Procedure-4",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/core/modul-prozedur/StructureDefinition/Procedure"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "completed",
      "category" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "363680008",
          "display" : "Radiographic imaging procedure"
        }]
      },
      "code" : {
        "coding" : [{
          "system" : "http://fhir.de/CodeSystem/bfarm/ops",
          "version" : "2025",
          "code" : "3-20",
          "display" : "Computertomographie [CT], nativ"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "performedDateTime" : "2022-12-19",
      "bodySite" : [{
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "818983003",
          "display" : "Abdomen"
        }]
      },
      {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "51185008",
          "display" : "Thoracic structure"
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "Procedure/PatientKimMusterperson-Procedure-4"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Procedure/PatientKimMusterperson-Procedure-5",
    "resource" : {
      "resourceType" : "Procedure",
      "id" : "PatientKimMusterperson-Procedure-5",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/core/modul-prozedur/StructureDefinition/Procedure"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "completed",
      "category" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "363680008",
          "display" : "Radiographic imaging procedure"
        }]
      },
      "code" : {
        "coding" : [{
          "system" : "http://fhir.de/CodeSystem/bfarm/ops",
          "version" : "2025",
          "code" : "3-20",
          "display" : "Computertomographie [CT], nativ"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "performedDateTime" : "2023-03-20",
      "bodySite" : [{
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "818983003",
          "display" : "Abdomen"
        }]
      },
      {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "51185008",
          "display" : "Thoracic structure"
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "Procedure/PatientKimMusterperson-Procedure-5"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Procedure/PatientKimMusterperson-Procedure-6",
    "resource" : {
      "resourceType" : "Procedure",
      "id" : "PatientKimMusterperson-Procedure-6",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/core/modul-prozedur/StructureDefinition/Procedure"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "completed",
      "category" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "363680008",
          "display" : "Radiographic imaging procedure"
        }]
      },
      "code" : {
        "coding" : [{
          "system" : "http://fhir.de/CodeSystem/bfarm/ops",
          "version" : "2025",
          "code" : "3-20",
          "display" : "Computertomographie [CT], nativ"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "performedDateTime" : "2023-08-20",
      "bodySite" : [{
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "818983003",
          "display" : "Abdomen"
        }]
      },
      {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "51185008",
          "display" : "Thoracic structure"
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "Procedure/PatientKimMusterperson-Procedure-6"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Procedure/PatientKimMusterperson-Procedure-7",
    "resource" : {
      "resourceType" : "Procedure",
      "id" : "PatientKimMusterperson-Procedure-7",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/core/modul-prozedur/StructureDefinition/Procedure"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "completed",
      "category" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "363680008",
          "display" : "Radiographic imaging procedure"
        }]
      },
      "code" : {
        "coding" : [{
          "system" : "http://fhir.de/CodeSystem/bfarm/ops",
          "version" : "2025",
          "code" : "3-20",
          "display" : "Computertomographie [CT], nativ"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "performedDateTime" : "2023-10-22",
      "bodySite" : [{
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "818983003",
          "display" : "Abdomen"
        }]
      },
      {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "51185008",
          "display" : "Thoracic structure"
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "Procedure/PatientKimMusterperson-Procedure-7"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-1",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-1",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-1"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "128462008",
          "display" : "Metastatic malignant neoplasm (disorder)"
        }]
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "41647002",
          "display" : "No evidence of (contextual qualifier) (qualifier value)"
        }],
        "text" : "kein Hinweis auf thorakale Metastasierung"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-1"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-2",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-2",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-1"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "255227004",
          "display" : "Recurrent"
        }]
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "41647002",
          "display" : "No evidence of (contextual qualifier) (qualifier value)"
        }],
        "text" : "kein Hinweis auf Lokalrezidiv"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-2"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-3",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-3",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-1"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "389026000",
          "display" : "Ascites"
        }]
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "860638000",
          "display" : "No ascites"
        }],
        "text" : "kein Aszites"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-3"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-4",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-4",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-1"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "237679004",
          "display" : "Status post (contextual qualifier) (qualifier value)"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "112231000",
          "display" : "Atypical (qualifier value)"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "174430004",
          "display" : "Resection of segment of liver (procedure)"
        }]
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "309201001",
          "display" : "Ascitic fluid specimen"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "262061000",
          "display" : "After surgery"
        }],
        "text" : "Flüssigkeitskollektion angrenzend DD postoperativ"
      },
      "bodySite" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "181247007",
          "display" : "Entire duodenum"
        }]
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-4"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-5",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-5",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-2"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "237679004",
          "display" : "Status post (contextual qualifier) (qualifier value)"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "112231000",
          "display" : "Atypical"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "174430004",
          "display" : "Resection of segment of liver (procedure)"
        }]
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "420341009",
          "display" : "Constant"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "309201001",
          "display" : "Ascitic fluid specimen"
        }],
        "text" : "konstante Flüssigkeitskollektion angrenzend"
      },
      "bodySite" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "181247007",
          "display" : "Entire duodenum"
        }]
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-5"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-6",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-6",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-2"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "389026000",
          "display" : "Ascites"
        }]
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "860638000",
          "display" : "No ascites"
        }],
        "text" : "kein Aszites"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-6"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-7",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-7",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-2"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "255227004",
          "display" : "Recurrent"
        }]
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "41647002",
          "display" : "No evidence of (contextual qualifier) (qualifier value)"
        }],
        "text" : "kein Hinweis auf Lokalrezidiv"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-7"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-8",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-8",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-2"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "112231000",
          "display" : "Atypical"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "1217294009",
          "display" : "Ground glass opacity"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "44714003",
          "display" : "Structure of upper lobe of left lung"
        }],
        "text" : "im linken Oberlappen der Lunge diskrete milchglasartige Trübung"
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "41647002",
          "display" : "No evidence of (contextual qualifier) (qualifier value)"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "255058005",
          "display" : "Neoplasm of thorax"
        }],
        "text" : "kein Hinweis auf thorakale Filiae"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-8"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-9",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-9",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-3"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "237679004",
          "display" : "Status post (contextual qualifier) (qualifier value)"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "112231000",
          "display" : "Atypical"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "174430004",
          "display" : "Resection of segment of liver (procedure)"
        }]
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "309201001",
          "display" : "Ascitic fluid specimen"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "249567002",
          "display" : "Liver edge (finding)"
        }],
        "text" : "regrediente Flüssigkeitskollektion am Leberrand"
      },
      "bodySite" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "181268008",
          "display" : "Entire liver"
        }]
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-9"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-10",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-10",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-3"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "237679004",
          "display" : "Status post (contextual qualifier) (qualifier value)"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "112231000",
          "display" : "Atypical"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "174430004",
          "display" : "Resection of segment of liver (procedure)"
        }]
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "94381002",
          "display" : "Metastatic malignant neoplasm to liver (disorder)"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "41647002",
          "display" : "No evidence of (contextual qualifier) (qualifier value)"
        }],
        "text" : "Darüberhinaus kein Hinweis auf Leberfilialisierung."
      },
      "bodySite" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "181268008",
          "display" : "Entire liver"
        }]
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-10"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-11",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-11",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-3"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "389026000",
          "display" : "Ascites"
        }]
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "860638000",
          "display" : "No ascites"
        }],
        "text" : "kein Aszites"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-11"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-12",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-12",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-3"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "255227004",
          "display" : "Recurrent"
        }]
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "41647002",
          "display" : "No evidence of (contextual qualifier) (qualifier value)"
        }],
        "text" : "kein Hinweis auf Lokalrezidiv"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-12"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-13",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-13",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-3"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "255227004",
          "display" : "Recurrent"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "1217294009",
          "display" : "Ground glass opacity"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "44714003",
          "display" : "Structure of upper lobe of left lung"
        }],
        "text" : "regrediente Milchglasinfiltrate im linken Oberlappen"
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "112231000",
          "display" : "Atypical"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "257552002",
          "display" : "Inflammation"
        }],
        "text" : "a.e. atypisch entzündlich"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-13"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-14",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-14",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-3"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "245276004",
          "display" : "Mediastinal lymph node group"
        }],
        "text" : "mediastinaler Lymphknoten"
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "258283002",
          "display" : "Lymphomatous nodal involvement"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "373067005",
          "display" : "No"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "385420005",
          "display" : "Contrast media"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "151174005",
          "display" : "Drug intake observed"
        }],
        "text" : "vermehrter mediastinaler Lymphknotenbesatz ohne Kontrastmittelaufnahme"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-14"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-15",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-15",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-3"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "245276004",
          "display" : "Mediastinal lymph node group"
        }],
        "text" : "mediastinaler Lymphknoten"
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "373067005",
          "display" : "No"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "15454001",
          "display" : "Increased size"
        }],
        "text" : "ohne pathologische Vergrößerung"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-15"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-16",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-16",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-4"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "255314001",
          "display" : "Progressive"
        }],
        "text" : "Progredienter Aszites"
      },
      "valueQuantity" : {
        "value" : 700,
        "unit" : "ml",
        "system" : "http://unitsofmeasure.org",
        "code" : "mL"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-16"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-17",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-17",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-4"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "362700006",
          "display" : "Entire peritoneal serous membrane of peritoneum"
        }],
        "text" : "Peritonealblatt"
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "385420005",
          "display" : "Contrast media"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "49608001",
          "display" : "Irregular"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "260366006",
          "display" : "Increase"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "151174005",
          "display" : "Drug intake observed"
        }],
        "text" : "Peritonealblatt mit zunehmender, unregelmäßiger KM-Aufnahme"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-17"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-18",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-18",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-4"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "836274002",
          "display" : "Carcinomatosis of peritoneum"
        }],
        "text" : "Peritonealkarzinose"
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "255314001",
          "display" : "Progressive"
        }],
        "text" : "Progress"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-18"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-19",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-19",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-4"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "80266002",
          "display" : "True pelvis"
        }],
        "text" : "kleinen Becken"
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "255227004",
          "display" : "Recurrent"
        }],
        "text" : "Lokalrezidiv bei kontrastmittelaufnehmender Raumforderung"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-19"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-20",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-20",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-5"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "389026000",
          "display" : "Ascites"
        }],
        "text" : "Aszites"
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "37865006",
          "display" : "Regressive"
        }],
        "text" : "Regredient"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-20"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-21",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-21",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-5"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "80266002",
          "display" : "True pelvis"
        }],
        "text" : "im kleinen Becken"
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "37865006",
          "display" : "Regressive"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "385420005",
          "display" : "Contrast media"
        }],
        "text" : "rückläufige KM-Aufnahme der lokalrezidivsuspekten Raumforderung"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-21"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-22",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-22",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-5"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "274744005",
          "display" : "Localized enlarged lymph nodes"
        }],
        "text" : "zahlenmäßig vermehrten LK im Mediastinum"
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "37865006",
          "display" : "Regressive"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "385420005",
          "display" : "Contrast media"
        }],
        "text" : "noch flaue, aber insgesamt regrediente KM-Aufnhame"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-22"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-23",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-23",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-5"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "52988006",
          "display" : "Lesion"
        }],
        "text" : "Läsion"
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "373067005",
          "display" : "No"
        }],
        "text" : "keine neue"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-23"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-24",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-24",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-6"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "389026000",
          "display" : "Ascites"
        }]
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "860638000",
          "display" : "No ascites"
        }],
        "text" : "kein Aszites"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-24"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-25",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-25",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-6"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "255227004",
          "display" : "Recurrent"
        }],
        "text" : "Lokalrezidiv"
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "37865006",
          "display" : "Regressive"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "373067005",
          "display" : "No"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "385420005",
          "display" : "Contrast media"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "151174005",
          "display" : "Drug intake observed"
        }],
        "text" : "regredientes Lokalrezidiv ohne KM-Aufnahme im kleinen Becken"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-25"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-26",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-26",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-7"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "80266002",
          "display" : "True pelvis"
        }],
        "text" : "kleinen Becken"
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "255606000",
          "display" : "Minor"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "389026000",
          "display" : "Ascites"
        }],
        "text" : "geringer Aszites"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-26"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-27",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-27",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-7"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "237679004",
          "display" : "Status post (contextual qualifier) (qualifier value)"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "246455001",
          "display" : "Recurrence"
        }],
        "text" : "vormals KM-aufnehmendes Lokalrezidiv im kleinen Becken"
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "246455001",
          "display" : "Recurrence"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "263920009",
          "display" : "Unrecordable"
        }],
        "text" : "aktuell metrisch nur noch schwer fassbar"
      },
      "bodySite" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "80266002",
          "display" : "True pelvis"
        }]
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-27"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-29",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-29",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-7"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "245276004",
          "display" : "Mediastinal lymph node group"
        }],
        "text" : "mediastinale Lymphknoten"
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "35105006",
          "display" : "Increased"
        }],
        "text" : "formal noch vermehrte"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-29"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-30",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "PatientKimMusterperson-Observation-30",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/PatientKimMusterperson-Procedure-7"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "245276004",
          "display" : "Mediastinal lymph node group"
        }],
        "text" : "mediastinale Lymphknoten"
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "373067005",
          "display" : "No"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "385420005",
          "display" : "Contrast media"
        },
        {
          "system" : "http://snomed.info/sct",
          "code" : "151174005",
          "display" : "Drug intake observed"
        }],
        "text" : "nicht mehr KM-aufnehmende"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/PatientKimMusterperson-Observation-30"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/ClinicalImpression/MII-EXA-MTB-Follow-Up-ClinicalImpression-1",
    "resource" : {
      "resourceType" : "ClinicalImpression",
      "id" : "MII-EXA-MTB-Follow-Up-ClinicalImpression-1",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-follow-up-clinicalimpression|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "completed",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "390906007",
          "display" : "Follow-up encounter (procedure)"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-10-22",
      "previous" : {
        "reference" : "ClinicalImpression/mii-exa-mtb-kim-musterperson-behandlungsepisode"
      },
      "investigation" : [{
        "code" : {
          "coding" : [{
            "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-follow-up-status",
            "code" : "completed"
          }]
        }
      }],
      "supportingInfo" : [{
        "reference" : "Procedure/MII-EXA-MTB-Systemische-Therapie-1"
      },
      {
        "reference" : "Claim/MII-EXA-MTB-Antrag-Kostenuebernahme-1"
      },
      {
        "reference" : "ClaimResponse/MII-EXA-MTB-Antwort-Kostenuebernahme-1"
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "ClinicalImpression/MII-EXA-MTB-Follow-Up-ClinicalImpression-1"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Procedure/MII-EXA-MTB-Systemische-Therapie-1",
    "resource" : {
      "resourceType" : "Procedure",
      "id" : "MII-EXA-MTB-Systemische-Therapie-1",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-therapie|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "extensions"
      },
      "extension" : [{
        "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-ex-onko-systemische-therapie-intention",
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-intention",
            "code" : "K"
          }]
        }
      }],
      "basedOn" : [{
        "reference" : "CarePlan/mii-exa-mtb-kim-musterperson-therapieplan"
      }],
      "status" : "completed",
      "statusReason" : {
        "coding" : [{
          "code" : "regular-completion"
        }]
      },
      "category" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "367336001",
          "display" : "Chemotherapy (procedure)"
        }]
      },
      "code" : {
        "coding" : [{
          "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-therapie-typ",
          "code" : "CH"
        },
        {
          "system" : "http://fhir.de/CodeSystem/bfarm/ops",
          "version" : "2023",
          "code" : "8-54",
          "display" : "Zytostatische Chemotherapie, Immuntherapie und antiretrovirale Therapie"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "performedPeriod" : {
        "start" : "2023-06-24",
        "end" : "2023-10-12"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Procedure/MII-EXA-MTB-Systemische-Therapie-1"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-1",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MII-EXA-MTB-Systemische-Therapie-Medication-1",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemtherapie-medication-statement",
        "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-therapie-medication-statement|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "basedOn" : [{
        "reference" : "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
      }],
      "partOf" : [{
        "reference" : "Procedure/MII-EXA-MTB-Systemische-Therapie-1"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fdasis.nlm.nih.gov",
          "code" : "98DE7VN88D",
          "display" : "MIRVETUXIMAB SORAVTANSINE"
        },
        {
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "version" : "2025",
          "code" : "L01FX26",
          "display" : "Mirvetuximab soravtansin"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectivePeriod" : {
        "start" : "2023-06-24",
        "end" : "2023-06-24"
      },
      "note" : [{
        "text" : "24.06.2023 Z1 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"
      }],
      "dosage" : [{
        "timing" : {
          "event" : ["2023-06-24"]
        },
        "doseAndRate" : [{
          "doseQuantity" : {
            "value" : 6,
            "unit" : "mg/kg KG",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg/kg{KG}"
          }
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-1"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-2",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MII-EXA-MTB-Systemische-Therapie-Medication-2",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemtherapie-medication-statement",
        "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-therapie-medication-statement|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "basedOn" : [{
        "reference" : "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
      }],
      "partOf" : [{
        "reference" : "Procedure/MII-EXA-MTB-Systemische-Therapie-1"
      }],
      "status" : "completed",
      "statusReason" : [{
        "coding" : [{
          "code" : "E"
        }]
      }],
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fdasis.nlm.nih.gov",
          "code" : "98DE7VN88D",
          "display" : "MIRVETUXIMAB SORAVTANSINE"
        },
        {
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "version" : "2025",
          "code" : "L01FX26",
          "display" : "Mirvetuximab soravtansin"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectivePeriod" : {
        "start" : "2023-07-16",
        "end" : "2023-07-16"
      },
      "note" : [{
        "text" : "16.07.2023 Z2 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"
      }],
      "dosage" : [{
        "timing" : {
          "event" : ["2023-07-16"]
        },
        "doseAndRate" : [{
          "doseQuantity" : {
            "value" : 6,
            "unit" : "mg/kg KG",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg/kg{KG}"
          }
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-2"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-3",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MII-EXA-MTB-Systemische-Therapie-Medication-3",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemtherapie-medication-statement",
        "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-therapie-medication-statement|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "basedOn" : [{
        "reference" : "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
      }],
      "partOf" : [{
        "reference" : "Procedure/MII-EXA-MTB-Systemische-Therapie-1"
      }],
      "status" : "completed",
      "statusReason" : [{
        "coding" : [{
          "code" : "E"
        }]
      }],
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fdasis.nlm.nih.gov",
          "code" : "98DE7VN88D",
          "display" : "MIRVETUXIMAB SORAVTANSINE"
        },
        {
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "version" : "2025",
          "code" : "L01FX26",
          "display" : "Mirvetuximab soravtansin"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectivePeriod" : {
        "start" : "2023-08-07",
        "end" : "2023-08-07"
      },
      "note" : [{
        "text" : "07.08.2023 Z3 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"
      }],
      "dosage" : [{
        "timing" : {
          "event" : ["2023-08-07"]
        },
        "doseAndRate" : [{
          "doseQuantity" : {
            "value" : 6,
            "unit" : "mg/kg KG",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg/kg{KG}"
          }
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-3"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-4",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MII-EXA-MTB-Systemische-Therapie-Medication-4",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemtherapie-medication-statement",
        "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-therapie-medication-statement|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "basedOn" : [{
        "reference" : "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
      }],
      "partOf" : [{
        "reference" : "Procedure/MII-EXA-MTB-Systemische-Therapie-1"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fdasis.nlm.nih.gov",
          "code" : "98DE7VN88D",
          "display" : "MIRVETUXIMAB SORAVTANSINE"
        },
        {
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "version" : "2025",
          "code" : "L01FX26",
          "display" : "Mirvetuximab soravtansin"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectivePeriod" : {
        "start" : "2023-08-29",
        "end" : "2023-08-29"
      },
      "note" : [{
        "text" : "29.08.2023 Z4 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"
      }],
      "dosage" : [{
        "timing" : {
          "event" : ["2023-08-29"]
        },
        "doseAndRate" : [{
          "doseQuantity" : {
            "value" : 6,
            "unit" : "mg/kg KG",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg/kg{KG}"
          }
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-4"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-5",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MII-EXA-MTB-Systemische-Therapie-Medication-5",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemtherapie-medication-statement",
        "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-therapie-medication-statement|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "basedOn" : [{
        "reference" : "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
      }],
      "partOf" : [{
        "reference" : "Procedure/MII-EXA-MTB-Systemische-Therapie-1"
      }],
      "status" : "completed",
      "statusReason" : [{
        "coding" : [{
          "code" : "E"
        }]
      }],
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fdasis.nlm.nih.gov",
          "code" : "98DE7VN88D",
          "display" : "MIRVETUXIMAB SORAVTANSINE"
        },
        {
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "version" : "2025",
          "code" : "L01FX26",
          "display" : "Mirvetuximab soravtansin"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectivePeriod" : {
        "start" : "2023-09-20",
        "end" : "2023-09-20"
      },
      "note" : [{
        "text" : "20.09.2023 Z2 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"
      }],
      "dosage" : [{
        "timing" : {
          "event" : ["2023-09-20"]
        },
        "doseAndRate" : [{
          "doseQuantity" : {
            "value" : 6,
            "unit" : "mg/kg KG",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg/kg{KG}"
          }
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-5"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-6",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MII-EXA-MTB-Systemische-Therapie-Medication-6",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemtherapie-medication-statement",
        "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-therapie-medication-statement|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "basedOn" : [{
        "reference" : "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
      }],
      "partOf" : [{
        "reference" : "Procedure/MII-EXA-MTB-Systemische-Therapie-1"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fdasis.nlm.nih.gov",
          "code" : "98DE7VN88D",
          "display" : "MIRVETUXIMAB SORAVTANSINE"
        },
        {
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "version" : "2025",
          "code" : "L01FX26",
          "display" : "Mirvetuximab soravtansin"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectivePeriod" : {
        "start" : "2023-10-12",
        "end" : "2023-10-12"
      },
      "note" : [{
        "text" : "12.10.2023 Z3 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"
      }],
      "dosage" : [{
        "timing" : {
          "event" : ["2023-10-12"]
        },
        "doseAndRate" : [{
          "doseQuantity" : {
            "value" : 6,
            "unit" : "mg/kg KG",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg/kg{KG}"
          }
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-6"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/MII-EXA-MTB-Response-Befund-1",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "MII-EXA-MTB-Response-Befund-1",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-response-befund|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/MII-EXA-MTB-Systemische-Therapie-1"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "396432002",
          "display" : "Status of regression of tumor (observable entity)"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "focus" : [{
        "reference" : "Condition/PatientKimMusterperson-PrimaryDiagnosis-2"
      }],
      "effectiveDateTime" : "2023-08-20",
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-response-befund-beurteilung",
          "code" : "CR",
          "display" : "Complete Response"
        }]
      },
      "method" : {
        "coding" : [{
          "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-response-befund-beurteilungsmethode",
          "code" : "RECIST",
          "display" : "RECIST"
        }]
      },
      "component" : [{
        "code" : {
          "coding" : [{
            "system" : "http://snomed.info/sct",
            "code" : "399656008",
            "display" : "Presence of metastatic neoplasm in regional lymph node (observable entity)"
          }]
        },
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-verlauf-lymphknoten",
            "code" : "K",
            "display" : "kein Lymphknotenbefall nachweisbar"
          }]
        }
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/MII-EXA-MTB-Response-Befund-1"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/MII-EXA-MTB-Response-Befund-2",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "MII-EXA-MTB-Response-Befund-2",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-response-befund|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/MII-EXA-MTB-Systemische-Therapie-1"
      }],
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "396432002",
          "display" : "Status of regression of tumor (observable entity)"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "focus" : [{
        "reference" : "Condition/PatientKimMusterperson-PrimaryDiagnosis-2"
      }],
      "effectiveDateTime" : "2023-10-22",
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-response-befund-beurteilung",
          "code" : "PR",
          "display" : "Partial Response"
        }]
      },
      "method" : {
        "coding" : [{
          "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-response-befund-beurteilungsmethode",
          "code" : "RECIST",
          "display" : "RECIST"
        }]
      },
      "component" : [{
        "code" : {
          "coding" : [{
            "system" : "http://snomed.info/sct",
            "code" : "399656008",
            "display" : "Presence of metastatic neoplasm in regional lymph node (observable entity)"
          }]
        },
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-verlauf-lymphknoten",
            "code" : "K",
            "display" : "kein Lymphknotenbefall nachweisbar"
          }]
        }
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/MII-EXA-MTB-Response-Befund-2"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Claim/MII-EXA-MTB-Antrag-Kostenuebernahme-1",
    "resource" : {
      "resourceType" : "Claim",
      "id" : "MII-EXA-MTB-Antrag-Kostenuebernahme-1",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-antrag-kostenuebernahme|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "active",
      "type" : {
        "coding" : [{
          "code" : "institutional"
        }]
      },
      "use" : "claim",
      "patient" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "created" : "2023-03-10",
      "provider" : {
        "reference" : "Organization/MyHospital"
      },
      "priority" : {
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/processpriority",
          "code" : "normal"
        }]
      },
      "related" : [{
        "relationship" : {
          "coding" : [{
            "code" : "initial-claim"
          }]
        }
      }],
      "prescription" : {
        "reference" : "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
      },
      "careTeam" : [{
        "sequence" : 1,
        "provider" : {
          "reference" : "Organization/MyInsurer"
        },
        "responsible" : true
      }],
      "insurance" : [{
        "sequence" : 1,
        "focal" : true,
        "coverage" : {
          "reference" : "Coverage/MyCoverage"
        },
        "claimResponse" : {
          "reference" : "ClaimResponse/MII-EXA-MTB-Antwort-Kostenuebernahme-1"
        }
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "Claim/MII-EXA-MTB-Antrag-Kostenuebernahme-1"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/ClaimResponse/MII-EXA-MTB-Antwort-Kostenuebernahme-1",
    "resource" : {
      "resourceType" : "ClaimResponse",
      "id" : "MII-EXA-MTB-Antwort-Kostenuebernahme-1",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-antwort-kostenuebernahme|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "active",
      "type" : {
        "coding" : [{
          "code" : "institutional"
        }]
      },
      "use" : "claim",
      "patient" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "created" : "2023-05-01",
      "insurer" : {
        "reference" : "Organization/MyHospital"
      },
      "request" : {
        "reference" : "Claim/MII-EXA-MTB-Antrag-Kostenuebernahme-1"
      },
      "outcome" : "complete"
    },
    "request" : {
      "method" : "PUT",
      "url" : "ClaimResponse/MII-EXA-MTB-Antwort-Kostenuebernahme-1"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Specimen/PatientKimMusterperson-Specimen-1",
    "resource" : {
      "resourceType" : "Specimen",
      "id" : "PatientKimMusterperson-Specimen-1",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "identifier" : [{
        "value" : "Z 230201/23"
      }],
      "accessionIdentifier" : {
        "value" : "Z 230201/23"
      },
      "status" : "available",
      "type" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "309201001",
          "display" : "Ascitic fluid specimen"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "collection" : {
        "collectedDateTime" : "2023-01-02",
        "quantity" : {
          "value" : 20,
          "unit" : "mL",
          "system" : "http://unitsofmeasure.org",
          "code" : "mL"
        },
        "method" : {
          "coding" : [{
            "system" : "http://snomed.info/sct",
            "code" : "178012008"
          }]
        }
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Specimen/PatientKimMusterperson-Specimen-1"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Procedure/MTBChemo1Procedure",
    "resource" : {
      "resourceType" : "Procedure",
      "id" : "MTBChemo1Procedure",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-vortherapie|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "extensions"
      },
      "extension" : [{
        "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-ex-onko-systemische-therapie-intention",
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-intention",
            "code" : "K"
          }]
        }
      }],
      "status" : "completed",
      "category" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "277132007"
        }]
      },
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "367336001"
        },
        {
          "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-therapie-typ",
          "code" : "CH"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "performedPeriod" : {
        "start" : "2023-01-04",
        "end" : "2023-05-24"
      },
      "outcome" : {
        "coding" : [{
          "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-therapie-ende-grund",
          "code" : "W"
        }],
        "text" : "Reguläres Ende mit Substanzwechsel"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Procedure/MTBChemo1Procedure"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement1",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MTBChemo1MedicationStatement1",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/MTBChemo1Procedure"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "text" : "Z1 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2, d1"
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-01-04"
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MTBChemo1MedicationStatement1"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement1-1",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MTBChemo1MedicationStatement1-1",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/MTBChemo1Procedure"
      },
      {
        "reference" : "MedicationStatement/MTBChemo1MedicationStatement1"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "code" : "L01XA02"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-01-04",
      "note" : [{
        "text" : "Z1 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"
      }],
      "dosage" : [{
        "timing" : {
          "event" : ["2023-01-04"]
        },
        "doseAndRate" : [{
          "doseQuantity" : {
            "value" : 5,
            "unit" : "AUC",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg.min/ml"
          }
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MTBChemo1MedicationStatement1-1"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement1-2",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MTBChemo1MedicationStatement1-2",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/MTBChemo1Procedure"
      },
      {
        "reference" : "MedicationStatement/MTBChemo1MedicationStatement1"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "code" : "L01DB01"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-01-04",
      "note" : [{
        "text" : "Z1 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"
      }],
      "dosage" : [{
        "timing" : {
          "event" : ["2023-01-04"]
        },
        "doseAndRate" : [{
          "doseQuantity" : {
            "value" : 30,
            "unit" : "mg/m2",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg/m2"
          }
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MTBChemo1MedicationStatement1-2"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement2",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MTBChemo1MedicationStatement2",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/MTBChemo1Procedure"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "text" : "Z2 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2, d1"
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-02-01"
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MTBChemo1MedicationStatement2"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement2-1",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MTBChemo1MedicationStatement2-1",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/MTBChemo1Procedure"
      },
      {
        "reference" : "MedicationStatement/MTBChemo1MedicationStatement2"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "code" : "L01XA02"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-02-01",
      "note" : [{
        "text" : "Z2 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"
      }],
      "dosage" : [{
        "timing" : {
          "event" : ["2023-02-01"]
        },
        "doseAndRate" : [{
          "doseQuantity" : {
            "value" : 5,
            "unit" : "AUC",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg.min/ml"
          }
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MTBChemo1MedicationStatement2-1"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement2-2",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MTBChemo1MedicationStatement2-2",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/MTBChemo1Procedure"
      },
      {
        "reference" : "MedicationStatement/MTBChemo1MedicationStatement2"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "code" : "L01DB01"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-02-01",
      "note" : [{
        "text" : "Z2 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"
      }],
      "dosage" : [{
        "timing" : {
          "event" : ["2023-02-01"]
        },
        "doseAndRate" : [{
          "doseQuantity" : {
            "value" : 30,
            "unit" : "mg/m2",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg/m2"
          }
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MTBChemo1MedicationStatement2-2"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement3",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MTBChemo1MedicationStatement3",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/MTBChemo1Procedure"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "text" : "Z3 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2, d1"
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-03-01"
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MTBChemo1MedicationStatement3"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement3-1",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MTBChemo1MedicationStatement3-1",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/MTBChemo1Procedure"
      },
      {
        "reference" : "MedicationStatement/MTBChemo1MedicationStatement3"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "code" : "L01XA02"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-03-01",
      "note" : [{
        "text" : "Z3 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"
      }],
      "dosage" : [{
        "timing" : {
          "event" : ["2023-03-01"]
        },
        "doseAndRate" : [{
          "doseQuantity" : {
            "value" : 5,
            "unit" : "AUC",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg.min/ml"
          }
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MTBChemo1MedicationStatement3-1"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement3-2",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MTBChemo1MedicationStatement3-2",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/MTBChemo1Procedure"
      },
      {
        "reference" : "MedicationStatement/MTBChemo1MedicationStatement3"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "code" : "L01DB01"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-03-01",
      "note" : [{
        "text" : "Z3 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"
      }],
      "dosage" : [{
        "timing" : {
          "event" : ["2023-03-01"]
        },
        "doseAndRate" : [{
          "doseQuantity" : {
            "value" : 30,
            "unit" : "mg/m2",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg/m2"
          }
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MTBChemo1MedicationStatement3-2"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement4",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MTBChemo1MedicationStatement4",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/MTBChemo1Procedure"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "text" : "Z4 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2, d1"
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-03-29"
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MTBChemo1MedicationStatement4"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement4-1",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MTBChemo1MedicationStatement4-1",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/MTBChemo1Procedure"
      },
      {
        "reference" : "MedicationStatement/MTBChemo1MedicationStatement4"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "code" : "L01XA02"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-03-29",
      "note" : [{
        "text" : "Z4 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"
      }],
      "dosage" : [{
        "timing" : {
          "event" : ["2023-03-29"]
        },
        "doseAndRate" : [{
          "doseQuantity" : {
            "value" : 5,
            "unit" : "AUC",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg.min/ml"
          }
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MTBChemo1MedicationStatement4-1"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement4-2",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MTBChemo1MedicationStatement4-2",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/MTBChemo1Procedure"
      },
      {
        "reference" : "MedicationStatement/MTBChemo1MedicationStatement4"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "code" : "L01DB01"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-03-29",
      "note" : [{
        "text" : "Z4 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"
      }],
      "dosage" : [{
        "timing" : {
          "event" : ["2023-03-29"]
        },
        "doseAndRate" : [{
          "doseQuantity" : {
            "value" : 30,
            "unit" : "mg/m2",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg/m2"
          }
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MTBChemo1MedicationStatement4-2"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement5",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MTBChemo1MedicationStatement5",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/MTBChemo1Procedure"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "text" : "Z5 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2, d1"
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-04-26"
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MTBChemo1MedicationStatement5"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement5-1",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MTBChemo1MedicationStatement5-1",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/MTBChemo1Procedure"
      },
      {
        "reference" : "MedicationStatement/MTBChemo1MedicationStatement5"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "code" : "L01XA02"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-04-26",
      "note" : [{
        "text" : "Z5 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"
      }],
      "dosage" : [{
        "timing" : {
          "event" : ["2023-04-26"]
        },
        "doseAndRate" : [{
          "doseQuantity" : {
            "value" : 5,
            "unit" : "AUC",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg.min/ml"
          }
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MTBChemo1MedicationStatement5-1"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement5-2",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MTBChemo1MedicationStatement5-2",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/MTBChemo1Procedure"
      },
      {
        "reference" : "MedicationStatement/MTBChemo1MedicationStatement5"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "code" : "L01DB01"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-04-26",
      "note" : [{
        "text" : "Z5 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"
      }],
      "dosage" : [{
        "timing" : {
          "event" : ["2023-04-26"]
        },
        "doseAndRate" : [{
          "doseQuantity" : {
            "value" : 30,
            "unit" : "mg/m2",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg/m2"
          }
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MTBChemo1MedicationStatement5-2"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement6",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MTBChemo1MedicationStatement6",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/MTBChemo1Procedure"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "text" : "Z6 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2, d1"
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-05-24"
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MTBChemo1MedicationStatement6"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement6-1",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MTBChemo1MedicationStatement6-1",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/MTBChemo1Procedure"
      },
      {
        "reference" : "MedicationStatement/MTBChemo1MedicationStatement6"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "code" : "L01XA02"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-05-24",
      "note" : [{
        "text" : "Z6 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"
      }],
      "dosage" : [{
        "timing" : {
          "event" : ["2023-05-24"]
        },
        "doseAndRate" : [{
          "doseQuantity" : {
            "value" : 5,
            "unit" : "AUC",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg.min/ml"
          }
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MTBChemo1MedicationStatement6-1"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement6-2",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MTBChemo1MedicationStatement6-2",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "partOf" : [{
        "reference" : "Procedure/MTBChemo1Procedure"
      },
      {
        "reference" : "MedicationStatement/MTBChemo1MedicationStatement6"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "code" : "L01DB01"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-05-24",
      "note" : [{
        "text" : "Z6 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"
      }],
      "dosage" : [{
        "timing" : {
          "event" : ["2023-05-24"]
        },
        "doseAndRate" : [{
          "doseQuantity" : {
            "value" : 30,
            "unit" : "mg/m2",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg/m2"
          }
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MTBChemo1MedicationStatement6-2"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Procedure/MTBChemo2Procedure",
    "resource" : {
      "resourceType" : "Procedure",
      "id" : "MTBChemo2Procedure",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-vortherapie|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "extensions"
      },
      "extension" : [{
        "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-ex-onko-systemische-therapie-intention",
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-intention",
            "code" : "K"
          }]
        }
      }],
      "basedOn" : [{
        "reference" : "CarePlan/mii-exa-mtb-kim-musterperson-therapieplan"
      }],
      "status" : "completed",
      "category" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "277132007"
        }]
      },
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "367336001"
        },
        {
          "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-therapie-typ",
          "code" : "CH"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "performedPeriod" : {
        "start" : "2023-06-24",
        "end" : "2023-10-12"
      },
      "outcome" : {
        "coding" : [{
          "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-therapie-ende-grund",
          "code" : "E"
        }],
        "text" : "Reguläres Ende"
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Procedure/MTBChemo2Procedure"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MTBChemo2MedicationStatement1",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MTBChemo2MedicationStatement1",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "basedOn" : [{
        "reference" : "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
      }],
      "partOf" : [{
        "reference" : "Procedure/MTBChemo2Procedure"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fdasis.nlm.nih.gov",
          "code" : "98DE7VN88D",
          "display" : "MIRVETUXIMAB SORAVTANSINE"
        },
        {
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "version" : "2025",
          "code" : "L01FX26",
          "display" : "Mirvetuximab soravtansin"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-06-24",
      "note" : [{
        "text" : "Z1 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"
      }],
      "dosage" : [{
        "timing" : {
          "event" : ["2023-06-24"]
        },
        "doseAndRate" : [{
          "doseQuantity" : {
            "value" : 6,
            "unit" : "mg/kg KG",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg/kg{KG}"
          }
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MTBChemo2MedicationStatement1"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MTBChemo2MedicationStatement2",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MTBChemo2MedicationStatement2",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "basedOn" : [{
        "reference" : "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
      }],
      "partOf" : [{
        "reference" : "Procedure/MTBChemo2Procedure"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fdasis.nlm.nih.gov",
          "code" : "98DE7VN88D",
          "display" : "MIRVETUXIMAB SORAVTANSINE"
        },
        {
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "version" : "2025",
          "code" : "L01FX26",
          "display" : "Mirvetuximab soravtansin"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-07-16",
      "note" : [{
        "text" : "Z2 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"
      }],
      "dosage" : [{
        "timing" : {
          "event" : ["2023-07-16"]
        },
        "doseAndRate" : [{
          "doseQuantity" : {
            "value" : 6,
            "unit" : "mg/kg KG",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg/kg{KG}"
          }
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MTBChemo2MedicationStatement2"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MTBChemo2MedicationStatement3",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MTBChemo2MedicationStatement3",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "basedOn" : [{
        "reference" : "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
      }],
      "partOf" : [{
        "reference" : "Procedure/MTBChemo2Procedure"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fdasis.nlm.nih.gov",
          "code" : "98DE7VN88D",
          "display" : "MIRVETUXIMAB SORAVTANSINE"
        },
        {
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "version" : "2025",
          "code" : "L01FX26",
          "display" : "Mirvetuximab soravtansin"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-08-07",
      "note" : [{
        "text" : "Z3 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"
      }],
      "dosage" : [{
        "timing" : {
          "event" : ["2023-08-07"]
        },
        "doseAndRate" : [{
          "doseQuantity" : {
            "value" : 6,
            "unit" : "mg/kg KG",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg/kg{KG}"
          }
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MTBChemo2MedicationStatement3"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MTBChemo2MedicationStatement4",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MTBChemo2MedicationStatement4",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "basedOn" : [{
        "reference" : "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
      }],
      "partOf" : [{
        "reference" : "Procedure/MTBChemo2Procedure"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fdasis.nlm.nih.gov",
          "code" : "98DE7VN88D",
          "display" : "MIRVETUXIMAB SORAVTANSINE"
        },
        {
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "version" : "2025",
          "code" : "L01FX26",
          "display" : "Mirvetuximab soravtansin"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-08-29",
      "note" : [{
        "text" : "Z4 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"
      }],
      "dosage" : [{
        "timing" : {
          "event" : ["2023-08-29"]
        },
        "doseAndRate" : [{
          "doseQuantity" : {
            "value" : 6,
            "unit" : "mg/kg KG",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg/kg{KG}"
          }
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MTBChemo2MedicationStatement4"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MTBChemo2MedicationStatement5",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MTBChemo2MedicationStatement5",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "basedOn" : [{
        "reference" : "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
      }],
      "partOf" : [{
        "reference" : "Procedure/MTBChemo2Procedure"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fdasis.nlm.nih.gov",
          "code" : "98DE7VN88D",
          "display" : "MIRVETUXIMAB SORAVTANSINE"
        },
        {
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "version" : "2025",
          "code" : "L01FX26",
          "display" : "Mirvetuximab soravtansin"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-09-20",
      "note" : [{
        "text" : "Z5 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"
      }],
      "dosage" : [{
        "timing" : {
          "event" : ["2023-09-20"]
        },
        "doseAndRate" : [{
          "doseQuantity" : {
            "value" : 6,
            "unit" : "mg/kg KG",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg/kg{KG}"
          }
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MTBChemo2MedicationStatement5"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationStatement/MTBChemo2MedicationStatement6",
    "resource" : {
      "resourceType" : "MedicationStatement",
      "id" : "MTBChemo2MedicationStatement6",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "basedOn" : [{
        "reference" : "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
      }],
      "partOf" : [{
        "reference" : "Procedure/MTBChemo2Procedure"
      }],
      "status" : "completed",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fdasis.nlm.nih.gov",
          "code" : "98DE7VN88D",
          "display" : "MIRVETUXIMAB SORAVTANSINE"
        },
        {
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "version" : "2025",
          "code" : "L01FX26",
          "display" : "Mirvetuximab soravtansin"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2023-10-12",
      "note" : [{
        "text" : "Z6 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"
      }],
      "dosage" : [{
        "timing" : {
          "event" : ["2023-10-12"]
        },
        "doseAndRate" : [{
          "doseQuantity" : {
            "value" : 6,
            "unit" : "mg/kg KG",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg/kg{KG}"
          }
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationStatement/MTBChemo2MedicationStatement6"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/DiagnosticReport/mii-exa-mtb-kim-musterperson-ngs-bericht",
    "resource" : {
      "resourceType" : "DiagnosticReport",
      "id" : "mii-exa-mtb-kim-musterperson-ngs-bericht",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-ngs-bericht|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
          "code" : "GE",
          "display" : "Genetics"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "51969-4",
          "display" : "Genetic analysis report"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "issued" : "2023-03-28T00:00:00.000Z",
      "specimen" : [{
        "reference" : "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
      }],
      "result" : [{
        "reference" : "Observation/mii-exa-mtb-kim-musterperson-EinfacheVariante-TP53"
      },
      {
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        "reference" : "Observation/mii-exa-mtb-kim-musterperson-CNVariante-CCNE1"
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      "url" : "DiagnosticReport/mii-exa-mtb-kim-musterperson-ngs-bericht"
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    "fullUrl" : "http://example.org/fhir/Procedure/mii-exa-mtb-kim-musterperson-genomic-study",
    "resource" : {
      "resourceType" : "Procedure",
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          "reference" : "Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-1"
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        "url" : "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-ext",
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          "reference" : "Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-2"
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        "url" : "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-ext",
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          "reference" : "Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-3"
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      "method" : "PUT",
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  {
    "fullUrl" : "http://example.org/fhir/Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-1",
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      "resourceType" : "Procedure",
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            "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/genomic-study-method-type-cs",
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        }
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        "url" : "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-change-type",
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://www.sequenceontology.org",
            "code" : "SO:0001483",
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        }
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      {
        "url" : "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-genome-build",
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://loinc.org",
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        "reference" : "Patient/PatientKimMusterperson"
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      "method" : "PUT",
      "url" : "Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-1"
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    "fullUrl" : "http://example.org/fhir/Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-2",
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      "resourceType" : "Procedure",
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        "status" : "generated"
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        "coding" : [{
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        "reference" : "Patient/PatientKimMusterperson"
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      "method" : "PUT",
      "url" : "Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-2"
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  {
    "fullUrl" : "http://example.org/fhir/Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-3",
    "resource" : {
      "resourceType" : "Procedure",
      "id" : "mii-exa-mtb-kim-musterperson-genomic-study-analysis-3",
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      },
      "language" : "de",
      "text" : {
        "status" : "extensions"
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      "extension" : [{
        "url" : "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-method-type",
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/genomic-study-method-type-cs",
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        }
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      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
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      "method" : "PUT",
      "url" : "Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-3"
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    "fullUrl" : "http://example.org/fhir/Observation/mii-exa-mtb-kim-musterperson-EinfacheVariante-TP53",
    "resource" : {
      "resourceType" : "Observation",
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        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-einfache-variante|2027.0.0-ballot.1"]
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      "language" : "de",
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          "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
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        "coding" : [{
          "system" : "http://loinc.org",
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        "reference" : "Patient/PatientKimMusterperson"
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        "coding" : [{
          "system" : "http://loinc.org",
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          "coding" : [{
            "system" : "http://loinc.org",
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          "coding" : [{
            "system" : "http://loinc.org",
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            "system" : "http://varnomen.hgvs.org",
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    "fullUrl" : "http://example.org/fhir/Observation/mii-exa-mtb-kim-musterperson-DiagnostischeImplikation-TP53",
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      "resourceType" : "Observation",
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      "language" : "de",
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      "code" : {
        "coding" : [{
          "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
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      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
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            "system" : "http://loinc.org",
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        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://loinc.org",
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      "url" : "Observation/mii-exa-mtb-kim-musterperson-DiagnostischeImplikation-TP53"
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    "fullUrl" : "http://example.org/fhir/Observation/mii-exa-mtb-kim-musterperson-EinfacheVariante-PIK3R1",
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      "resourceType" : "Observation",
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      "text" : {
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    "fullUrl" : "http://example.org/fhir/Observation/mii-exa-mtb-kim-musterperson-TherapeutischeImplikation-PIK3R1",
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      "resourceType" : "Observation",
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    "fullUrl" : "http://example.org/fhir/Observation/mii-exa-mtb-kim-musterperson-CNVariante-CCNE1",
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      "resourceType" : "Observation",
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      "resourceType" : "ServiceRequest",
      "id" : "mii-exa-mtb-study-request-cldn6",
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        "valueDecimal" : 2.1
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        "coding" : [{
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          "display" : "Referral to clinical trial (procedure)"
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        "reference" : "Patient/PatientKimMusterperson"
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        "reference" : "ResearchStudy/mii-exa-mtb-study-cldn6"
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      "method" : "PUT",
      "url" : "ServiceRequest/mii-exa-mtb-study-request-cldn6"
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    "fullUrl" : "http://example.org/fhir/ResearchStudy/mii-exa-mtb-study-cldn6",
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      "resourceType" : "ResearchStudy",
      "id" : "mii-exa-mtb-study-cldn6",
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      "text" : {
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        "coding" : [{
          "code" : "treatment"
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          "code" : "phase-1"
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        "coding" : [{
          "system" : "http://snomed.info/sct",
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          "display" : "Solid tumor configuration"
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      }],
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        "text" : "Non-small cell lung cancer (NSCLC)"
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        "reference" : "Group/mii-exa-mtb-study-cldn6-eligibility-criteria"
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      },
      "sponsor" : {
        "reference" : "Organization/mii-exa-mtb-study-sponsor-biontech"
      },
      "principalInvestigator" : {
        "reference" : "PractitionerRole/mii-exa-mtb-study-investigator-biontech"
      },
      "site" : [{
        "reference" : "Location/mii-exa-mtb-study-cldn6-location-11"
      }],
      "arm" : [{
        "name" : "Part 1 - CLDN6 CAR-T: Dose escalation in lymphodepleted patients until the MTD and/or RP2D"
      },
      {
        "name" : "Part 2 Vaccine-modulated - CLDN6 uRNA-LPX/CLDN6 modRNA-LPX: Dose escalation until the MTD and/or RP2D"
      }],
      "objective" : [{
        "name" : "Occurrence of treatment-emergent adverse events (TEAEs) including ≥ Grade 3, serious, fatal TEAEs by relationship",
        "type" : {
          "coding" : [{
            "code" : "primary"
          }]
        }
      },
      {
        "name" : "Occurrence of dose reduction and discontinuation of investigational medicinal product (IMP) due to TEAEs",
        "type" : {
          "coding" : [{
            "code" : "primary"
          }]
        }
      },
      {
        "name" : "Occurrence of dose-limiting toxicity (DLT) during the DLT evaluation period",
        "type" : {
          "coding" : [{
            "code" : "primary"
          }]
        }
      },
      {
        "name" : "Change from baseline in the levels and kinetics of soluble immune factors measured by cytokine multiplex assay",
        "type" : {
          "coding" : [{
            "code" : "secondary"
          }]
        }
      },
      {
        "name" : "Objective response rate (ORR) defined as the proportion of patients in whom a complete response (CR) or partial response (PR) (per response evaluation criteria in solid tumors [RECIST 1.1]) is observed as best overall response",
        "type" : {
          "coding" : [{
            "code" : "secondary"
          }]
        }
      },
      {
        "name" : "Disease control rate (DCR) defined as the proportion of patients in whom a CR or PR or stable disease (SD) (per RECIST 1.1, SD assessed at least 6 weeks after the first dose) is observed as best overall response",
        "type" : {
          "coding" : [{
            "code" : "secondary"
          }]
        }
      },
      {
        "name" : "Duration of response (DOR) defined as the time from first objective response (CR or PR per RECIST 1.1) to first occurrence of objective progressive disease (PD) per RECIST 1.1/recurrence or death from any cause, whichever occurs first",
        "type" : {
          "coding" : [{
            "code" : "secondary"
          }]
        }
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "ResearchStudy/mii-exa-mtb-study-cldn6"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Group/mii-exa-mtb-study-cldn6-eligibility-criteria",
    "resource" : {
      "resourceType" : "Group",
      "id" : "mii-exa-mtb-study-cldn6-eligibility-criteria",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "type" : "person",
      "actual" : false,
      "quantity" : 145,
      "characteristic" : [{
        "code" : {
          "text" : "Eligibility Criteria"
        },
        "valueReference" : {
          "display" : "Inclusion Criteria:\n\n* Each patient enrolled in the trial must have CLDN6-positive tumor regardless of tumor histology defined as ≥ 50% of tumor cells expressing ≥ 2+ CLDN6 protein using a semi-quantitative immunohistochemistry (IHC) assay in a central laboratory for specific detection of CLDN6 protein expression in formalin-fixed, paraffin-embedded (FFPE) neoplastic tissues.\n* Availability of a FFPE tumor tissue sample. FFPE can be from an archival tumor tissue sample, and it should be from the most recent tumor tissue obtained. If this is not available, patient must be biopsied for CLDN6 staining.\n* Must have histological documentation of the original primary tumor via a pathology report.\n* Must have measurable disease per RECIST 1.1 (except for germ cell tumors, where patients can be evaluated according to Cancer-Antigen (CA)-125, Alpha-fetoprotein or human chorionic gonadotropin \\[as applicable\\] or ovarian cancer, where patients can be evaluated according to CA-125. The pre-treatment sample must be at least twice the upper limit of normal).\n* Must have a histologically confirmed solid tumor that is metastatic or unresectable and for which there is no available standard therapy likely to confer clinical benefit, or patient who is not a candidate for such available therapy.\n* Must be ≥ 18 years of age at the time the pre-screening informed consent is signed.\n* Must sign an informed consent form (ICF) indicating that he or she understands the purpose of and procedures required for the trial and are willing to participate in the trial prior to any trial-related assessments or procedures.\n* Must have an Eastern Cooperative Oncology Group performance status of 0 to 1.\n* Must have adequate coagulation function at screening as defined in the protocol.\n* Must have adequate hematologic function at screening as defined in the protocol.\n* Must have adequate hepatic function at screening as defined in the protocol.\n* Must have adequate renal function at screening as defined in the protocol.\n* Must be able to attend trial visits as required by the protocol.\n* Women of childbearing potential (WOCBP) must have a negative serum (beta-human chorionic gonadotropin) test/value at screening. Patients who are post-menopausal or permanently sterilized can be considered as not having reproductive potential.\n* WOCBP must agree not to donate eggs (ova, oocytes) for the purposes of assisted reproduction during the entire trial and thereafter.\n* WOCBP and men that are sexually active with a WOCBP and have not had a vasectomy must agree to use highly effective birth control method(s), as defined in the protocol. True abstinence is an acceptable alternative to the use of contraception.\n* Men must agree not to father a child or donate sperm, and WOCBP must agree not to become pregnant during the trial and for at least 12 months after the CLDN6 CAR-T infusion or CLDN6 RNA-LPX treatment.\n\nFor Part 2 only:\n\n* Histologically or cytologically confirmed solid tumor fulfilling inclusion criteria 1-4 that is metastatic or unresectable, and for whom there is no available standard therapy likely to confer clinical benefit, or patient who is not a candidate for such available therapy.\n\nExclusion Criteria:\n\n* Has received prior CAR-T therapy, except CLDN6 CAR-T therapy.\n* Has received vaccination with live virus vaccines within 6 weeks prior to the start of lymphodepletion (LD).\n* Receives concurrent systemic (oral or i.v.) steroid therapy \\> 10 mg prednisolone daily, or its equivalent, for an underlying condition.\n* Has side effects of any prior therapy or procedures for any medical condition not recovered to national cancer institute common terminology criteria for adverse events (CTCAE v.5) Grade ≤ 1.\n\nMedical conditions:\n\n* Current evidence of new or growing brain or spinal metastases during screening. Patients with known brain or spinal metastases may be eligible if they:\n\n  1. Have had radiotherapy or another appropriate therapy for the brain or spinal metastases,\n  2. Have no neurological symptoms,\n  3. Have stable brain or spinal disease on the computer tomography or magnetic resonance imaging scan within 4 weeks before signing of the ICF,\n  4. Are not undergoing acute corticosteroid therapy or steroid taper. Chronic steroid therapy is acceptable provided that the dose is stable for the last 14 days prior to screening (≤ 10 mg prednisolone daily or equivalent),\n  5. Do not require steroid therapy within 7 days before the first dose of CLDN6 CAR-T,\n  6. Do not have anticipated imminent fracture or cord compression due to spinal bone metastases.\n* Has history of epilepsy. Isolated seizures in the past or febrile seizures in childhood are permitted; has a history of a cerebrovascular accident or transient ischemic attack less than 6 months ago.\n* Pericardial effusion requiring any drainage is excluded.\n* Has an active autoimmune disease including but not limited to inflammatory bowel disease, systemic lupus erythematosus, ankylosing spondylitis, scleroderma, or multiple sclerosis. Has any active immunologic disorder requiring immunosuppression with steroids or other immunosuppressive agents with the exception of patients with isolated vitiligo, resolved childhood asthma or atopic dermatitis, controlled hypoadrenalism or hypopituitarism, and euthyroid patients with a history of Grave's disease. Patients with controlled hyperthyroidism must be negative for thyroglobulin, thyroid peroxidase antibodies, and thyroid-stimulating immunoglobulin prior to trial drug administration.\n* Seropositivity for human immunodeficiency virus.\n* Known history/positive serology for hepatitis B requiring active antiviral therapy (unless immune due to vaccination or resolved natural infection or unless passive immunization due to immunoglobulin therapy). Patients with positive serology must have hepatitis B virus viral load below the limit of quantification.\n* Active hepatitis C virus (HCV) infection; patients who have completed curative antiviral treatment with HCV viral load below the limit of quantification are allowed.\n* Has a known hypersensitivity to a component of CLDN6 CAR-T or CLDN6 RNA-LPX cancer vaccine drug product, or another similar compound.\n* Only for patients recruited for Part 2 with LD chemotherapy (CLDN6 CAR-T + CLDN6 RNA-LPX with LD chemotherapy): history of severe immediate hypersensitivity reaction to LD chemotherapy consisting of cyclophosphamide or fludarabine.\n* Has a history of another primary cancer within the 2 years prior to enrollment except for the following: Non-melanoma skin cancer, cervical carcinoma in situ, superficial bladder cancer, prostate cancer with currently undetectable prostate specific antigen, or other non-metastatic carcinoma that has been in complete remission without treatment for more than 2 years.\n* Receipt of allogenic stem cell transplantation in the 5 years prior to enrollment into the trial.\n* Patients with acute or chronic graft versus host disease.\n\nOther comorbidities:\n\n* Has abnormal electrocardiograms that are clinically significant, such as QT prolongation.\n* In the opinion of the Investigator, has any concurrent conditions that could pose an undue medical hazard or interfere with the interpretation of the trial results; these conditions include, but are not limited to:\n\n  1. Ongoing or active infection requiring antibiotic/antiviral/antifungal therapy\n  2. Concurrent congestive heart failure (New York Heart Association Functional Classification Class III or IV)\n  3. Concurrent unstable angina\n  4. Concurrent cardiac arrhythmia requiring treatment (excluding asymptomatic atrial fibrillation)\n  5. Acute coronary syndrome within the previous 6 months\n  6. Significant pulmonary disease (shortness of breath at rest or on mild exertion) for example due concurrent severe obstructive pulmonary disease.\n* Has a cognitive, psychological or psychosocial impediment that would impair the ability of the patient to receive therapy according to the protocol or adversely affect the ability of the patient to comply with the informed consent process, protocol, or protocol-required visits and procedures.\n* Is pregnant or breastfeeding"
        },
        "exclude" : false
      },
      {
        "code" : {
          "text" : "Accepts Healthy Volunteers"
        },
        "valueBoolean" : false,
        "exclude" : false
      },
      {
        "code" : {
          "text" : "Age"
        },
        "valueRange" : {
          "low" : {
            "value" : 18,
            "unit" : "year",
            "system" : "http://unitsofmeasure.org",
            "code" : "a"
          }
        },
        "exclude" : false
      },
      {
        "code" : {
          "text" : "Age Group"
        },
        "valueReference" : {
          "reference" : "Group/mii-exa-mtb-study-cldn6-eligibility-criteria-age-groups"
        },
        "exclude" : false
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "Group/mii-exa-mtb-study-cldn6-eligibility-criteria"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Group/mii-exa-mtb-study-cldn6-eligibility-criteria-age-groups",
    "resource" : {
      "resourceType" : "Group",
      "id" : "mii-exa-mtb-study-cldn6-eligibility-criteria-age-groups",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "type" : "person",
      "actual" : false,
      "characteristic" : [{
        "code" : {
          "text" : "Age Group (Adult)"
        },
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://snomed.info/sct",
            "code" : "41847000",
            "display" : "Adulthood (qualifier value)"
          }]
        },
        "exclude" : false
      },
      {
        "code" : {
          "text" : "Age Group (Older Adult)"
        },
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://snomed.info/sct",
            "code" : "271872005",
            "display" : "Old age (qualifier value)"
          }]
        },
        "exclude" : false
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "Group/mii-exa-mtb-study-cldn6-eligibility-criteria-age-groups"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Group/mii-exa-mtb-study-cldn6-comparison-group-0",
    "resource" : {
      "resourceType" : "Group",
      "id" : "mii-exa-mtb-study-cldn6-comparison-group-0",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "type" : "person",
      "actual" : false,
      "characteristic" : [{
        "code" : {
          "text" : "Exposed to"
        },
        "valueReference" : {
          "reference" : "EvidenceVariable/mii-exa-mtb-study-cldn6-evidence-variable-0",
          "display" : "Biological: CLDN6 CAR-T"
        },
        "exclude" : false
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "Group/mii-exa-mtb-study-cldn6-comparison-group-0"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/EvidenceVariable/mii-exa-mtb-study-cldn6-evidence-variable-0",
    "resource" : {
      "resourceType" : "EvidenceVariable",
      "id" : "mii-exa-mtb-study-cldn6-evidence-variable-0",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "active",
      "useContext" : [{
        "code" : {
          "system" : "http://snomed.info/sct",
          "code" : "362956003",
          "display" : "Procedure/intervention (navigational concept)"
        },
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://snomed.info/sct",
            "code" : "12893009",
            "display" : "Biological"
          }]
        }
      }],
      "characteristic" : [{
        "definitionReference" : {
          "reference" : "Group/mii-exa-mtb-study-cldn6-eligibility-criteria"
        }
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "EvidenceVariable/mii-exa-mtb-study-cldn6-evidence-variable-0"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Group/mii-exa-mtb-study-cldn6-comparison-group-1",
    "resource" : {
      "resourceType" : "Group",
      "id" : "mii-exa-mtb-study-cldn6-comparison-group-1",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "type" : "person",
      "actual" : false,
      "characteristic" : [{
        "code" : {
          "text" : "Exposed to"
        },
        "valueReference" : {
          "reference" : "EvidenceVariable/mii-exa-mtb-study-cldn6-evidence-variable-1",
          "display" : "Biological: CLDN6 uRNA-LPX/CLDN6 modRNA-LPX"
        },
        "exclude" : false
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "Group/mii-exa-mtb-study-cldn6-comparison-group-1"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/EvidenceVariable/mii-exa-mtb-study-cldn6-evidence-variable-1",
    "resource" : {
      "resourceType" : "EvidenceVariable",
      "id" : "mii-exa-mtb-study-cldn6-evidence-variable-1",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "active",
      "useContext" : [{
        "code" : {
          "system" : "http://snomed.info/sct",
          "code" : "362956003",
          "display" : "Procedure/intervention (navigational concept)"
        },
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://snomed.info/sct",
            "code" : "12893009",
            "display" : "Biological"
          }]
        }
      }],
      "characteristic" : [{
        "definitionReference" : {
          "reference" : "Group/mii-exa-mtb-study-cldn6-eligibility-criteria"
        }
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "EvidenceVariable/mii-exa-mtb-study-cldn6-evidence-variable-1"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Organization/mii-exa-mtb-study-sponsor-biontech",
    "resource" : {
      "resourceType" : "Organization",
      "id" : "mii-exa-mtb-study-sponsor-biontech",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "type" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/organization-type",
          "code" : "crs",
          "display" : "Clinical Research Sponsor"
        }]
      }],
      "name" : "BioNTech Cell & Gene Therapies GmbH"
    },
    "request" : {
      "method" : "PUT",
      "url" : "Organization/mii-exa-mtb-study-sponsor-biontech"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/PractitionerRole/mii-exa-mtb-study-investigator-biontech",
    "resource" : {
      "resourceType" : "PractitionerRole",
      "id" : "mii-exa-mtb-study-investigator-biontech",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/modul-studie/StructureDefinition/mii-pr-studie-beteiligte-person"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "code" : [{
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "768734005",
          "display" : "Study coordinator"
        }]
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "PractitionerRole/mii-exa-mtb-study-investigator-biontech"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-0",
    "resource" : {
      "resourceType" : "Location",
      "id" : "mii-exa-mtb-study-cldn6-location-0",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "name" : "Peter MacCallum Cancer Centre",
      "address" : {
        "city" : "Melbourne",
        "state" : "Victoria",
        "postalCode" : "3000",
        "country" : "Australia"
      },
      "position" : {
        "longitude" : 144.96332,
        "latitude" : -37.814
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Location/mii-exa-mtb-study-cldn6-location-0"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-1",
    "resource" : {
      "resourceType" : "Location",
      "id" : "mii-exa-mtb-study-cldn6-location-1",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "name" : "Charité - Universitätsmedizin Berlin - Campus Benjamin Franklin",
      "address" : {
        "city" : "Berlin",
        "postalCode" : "12200",
        "country" : "Germany"
      },
      "position" : {
        "longitude" : 13.41053,
        "latitude" : 52.52437
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Location/mii-exa-mtb-study-cldn6-location-1"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-2",
    "resource" : {
      "resourceType" : "Location",
      "id" : "mii-exa-mtb-study-cldn6-location-2",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "name" : "Universitätsklinikum Erlangen - Hämatologie & Intrinsische Onkologie - Medizinische Klinik 5",
      "address" : {
        "city" : "Erlangen",
        "postalCode" : "91054",
        "country" : "Germany"
      },
      "position" : {
        "longitude" : 11.00783,
        "latitude" : 49.59099
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Location/mii-exa-mtb-study-cldn6-location-2"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-3",
    "resource" : {
      "resourceType" : "Location",
      "id" : "mii-exa-mtb-study-cldn6-location-3",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "name" : "Universitätsklinikum Hamburg Eppendorf - II Medizinische Klinik und Poliklinik",
      "address" : {
        "city" : "Hamburg",
        "postalCode" : "20246",
        "country" : "Germany"
      },
      "position" : {
        "longitude" : 10.01534,
        "latitude" : 53.57532
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Location/mii-exa-mtb-study-cldn6-location-3"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-4",
    "resource" : {
      "resourceType" : "Location",
      "id" : "mii-exa-mtb-study-cldn6-location-4",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "name" : "Medizinische Hochschule Hannover - Klinik für Hämatologie, Hämostaseologie, Onkologie und Stammzelltransplantation",
      "address" : {
        "city" : "Hannover",
        "postalCode" : "30625",
        "country" : "Germany"
      },
      "position" : {
        "longitude" : 9.73322,
        "latitude" : 52.37052
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Location/mii-exa-mtb-study-cldn6-location-4"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-5",
    "resource" : {
      "resourceType" : "Location",
      "id" : "mii-exa-mtb-study-cldn6-location-5",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "name" : "Nationales Centrum für Tumorerkrankungen (NCT) Heidelberg",
      "address" : {
        "city" : "Heidelberg",
        "postalCode" : "69120",
        "country" : "Germany"
      },
      "position" : {
        "longitude" : 8.69079,
        "latitude" : 49.40768
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Location/mii-exa-mtb-study-cldn6-location-5"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-6",
    "resource" : {
      "resourceType" : "Location",
      "id" : "mii-exa-mtb-study-cldn6-location-6",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "name" : "Universitätsklinikum Köln AÖR-Centrum für Integrierte Onkologie (CIO)-Studienzentrum der Klinik I für Innere Medizin (CTU Cologne)",
      "address" : {
        "city" : "Köln",
        "postalCode" : "50937",
        "country" : "Germany"
      },
      "position" : {
        "longitude" : 6.95,
        "latitude" : 50.93333
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Location/mii-exa-mtb-study-cldn6-location-6"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-7",
    "resource" : {
      "resourceType" : "Location",
      "id" : "mii-exa-mtb-study-cldn6-location-7",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "name" : "Universitätsmedizin Mainz - III Medizinische Klinik und Poliklinik",
      "address" : {
        "city" : "Mainz",
        "postalCode" : "55131",
        "country" : "Germany"
      },
      "position" : {
        "longitude" : 8.2791,
        "latitude" : 49.98419
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Location/mii-exa-mtb-study-cldn6-location-7"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-8",
    "resource" : {
      "resourceType" : "Location",
      "id" : "mii-exa-mtb-study-cldn6-location-8",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "name" : "Universitätsklinikum Regensburg - Klinik und Poliklinik für Innere Medizin III",
      "address" : {
        "city" : "Regensburg",
        "postalCode" : "93053",
        "country" : "Germany"
      },
      "position" : {
        "longitude" : 12.10161,
        "latitude" : 49.01513
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Location/mii-exa-mtb-study-cldn6-location-8"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-9",
    "resource" : {
      "resourceType" : "Location",
      "id" : "mii-exa-mtb-study-cldn6-location-9",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "name" : "He Nederlands Kanker Instituut (The Netherlands Cancer Institute) - Antoni van Leeuwenhoek Ziekenhuis (NKI-AVL)",
      "address" : {
        "city" : "Amsterdam",
        "postalCode" : "1066",
        "country" : "Netherlands"
      },
      "position" : {
        "longitude" : 4.88969,
        "latitude" : 52.37403
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Location/mii-exa-mtb-study-cldn6-location-9"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-10",
    "resource" : {
      "resourceType" : "Location",
      "id" : "mii-exa-mtb-study-cldn6-location-10",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "name" : "Erasmus MC - Universitair Medisch Centrum - Medical oncology",
      "address" : {
        "city" : "Rotterdam",
        "postalCode" : "3015",
        "country" : "Netherlands"
      },
      "position" : {
        "longitude" : 4.47917,
        "latitude" : 51.9225
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Location/mii-exa-mtb-study-cldn6-location-10"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-11",
    "resource" : {
      "resourceType" : "Location",
      "id" : "mii-exa-mtb-study-cldn6-location-11",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "name" : "Karolinska Comprehensive Cancer Center Cancerstudieenheten Huddinge Karolinska Universitetssjukhuset",
      "address" : {
        "city" : "Stockholm",
        "postalCode" : "14186",
        "country" : "Sweden"
      },
      "position" : {
        "longitude" : 18.0649,
        "latitude" : 59.33258
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Location/mii-exa-mtb-study-cldn6-location-11"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/ResearchStudy/mii-exa-mtb-study-tedova",
    "resource" : {
      "resourceType" : "ResearchStudy",
      "id" : "mii-exa-mtb-study-tedova",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-studie|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "identifier" : [{
        "system" : "https://www.medizininformatik-initiative.de/fhir/modul-mtb/sid/nct",
        "value" : "04713514"
      }],
      "status" : "active"
    },
    "request" : {
      "method" : "PUT",
      "url" : "ResearchStudy/mii-exa-mtb-study-tedova"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/ServiceRequest/mii-exa-mtb-study-request-tedova",
    "resource" : {
      "resourceType" : "ServiceRequest",
      "id" : "mii-exa-mtb-study-request-tedova",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-studieneinschluss-anfrage|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "extensions"
      },
      "extension" : [{
        "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-prioritaet",
        "valueDecimal" : 2.2
      }],
      "status" : "draft",
      "intent" : "proposal",
      "category" : [{
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "110465008",
          "display" : "Clinical trial (procedure)"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "702475000",
          "display" : "Referral to clinical trial (procedure)"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "supportingInfo" : [{
        "reference" : "ResearchStudy/mii-exa-mtb-study-tedova"
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "ServiceRequest/mii-exa-mtb-study-request-tedova"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/ResearchStudy/mii-exa-mtb-study-ccne1",
    "resource" : {
      "resourceType" : "ResearchStudy",
      "id" : "mii-exa-mtb-study-ccne1",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-studie|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "active"
    },
    "request" : {
      "method" : "PUT",
      "url" : "ResearchStudy/mii-exa-mtb-study-ccne1"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/ServiceRequest/mii-exa-mtb-study-request-ccne1",
    "resource" : {
      "resourceType" : "ServiceRequest",
      "id" : "mii-exa-mtb-study-request-ccne1",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-studieneinschluss-anfrage|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "extensions"
      },
      "extension" : [{
        "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-prioritaet",
        "valueDecimal" : 2.3
      }],
      "status" : "draft",
      "intent" : "proposal",
      "category" : [{
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "110465008",
          "display" : "Clinical trial (procedure)"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "702475000",
          "display" : "Referral to clinical trial (procedure)"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "supportingInfo" : [{
        "reference" : "ResearchStudy/mii-exa-mtb-study-ccne1"
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "ServiceRequest/mii-exa-mtb-study-request-ccne1"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab",
    "resource" : {
      "resourceType" : "MedicationRequest",
      "id" : "mii-exa-mtb-medication-request-mirvetuximab",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "extensions"
      },
      "extension" : [{
        "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-prioritaet",
        "valuePositiveInt" : 1
      },
      {
        "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-evidenzgraduierung",
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-empfehlung-evidenzgrad",
            "code" : "m1A"
          }]
        }
      },
      {
        "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-publikation",
        "valueIdentifier" : {
          "system" : "http://doi.org",
          "value" : "10.1200/JCO.2022.40.16_suppl.5512"
        }
      },
      {
        "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-publikation",
        "valueIdentifier" : {
          "system" : "http://www.ncbi.nlm.nih.gov/pubmed",
          "value" : "38055253"
        }
      }],
      "status" : "completed",
      "intent" : "proposal",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fdasis.nlm.nih.gov",
          "code" : "98DE7VN88D",
          "display" : "MIRVETUXIMAB SORAVTANSINE"
        },
        {
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "version" : "2025",
          "code" : "L01FX26",
          "display" : "Mirvetuximab soravtansin"
        },
        {
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "version" : "2025",
          "code" : "L01FX",
          "display" : "Andere monoklonale Antikörper und Antikörper-Wirkstoff-Konjugate"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "authoredOn" : "2023-03-28",
      "reasonReference" : [{
        "reference" : "Condition/PatientKimMusterperson-PrimaryDiagnosis-2"
      }],
      "basedOn" : [{
        "reference" : "CarePlan/mii-exa-mtb-kim-musterperson-therapieplan"
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationRequest/mii-exa-mtb-medication-request-trastuzumab-deruxtecan",
    "resource" : {
      "resourceType" : "MedicationRequest",
      "id" : "mii-exa-mtb-medication-request-trastuzumab-deruxtecan",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "extensions"
      },
      "extension" : [{
        "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-prioritaet",
        "valuePositiveInt" : 3
      },
      {
        "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-evidenzgraduierung",
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-empfehlung-evidenzgrad",
            "code" : "m1B"
          }]
        }
      },
      {
        "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-publikation",
        "valueIdentifier" : {
          "system" : "http://www.ncbi.nlm.nih.gov/pubmed",
          "value" : "35665782"
        }
      },
      {
        "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-publikation",
        "valueIdentifier" : {
          "system" : "http://www.ncbi.nlm.nih.gov/pubmed",
          "value" : "37870536"
        }
      },
      {
        "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-publikation",
        "valueIdentifier" : {
          "system" : "http://doi.org",
          "value" : "10.1200/JCO.2023.41.17_suppl.LBA3000"
        }
      }],
      "status" : "draft",
      "intent" : "proposal",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "version" : "2025",
          "code" : "L01FD04",
          "display" : "Trastuzumab deruxtecan"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "authoredOn" : "2023-03-28",
      "reasonReference" : [{
        "reference" : "Condition/PatientKimMusterperson-PrimaryDiagnosis-2"
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationRequest/mii-exa-mtb-medication-request-trastuzumab-deruxtecan"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationRequest/mii-exa-mtb-medication-request-adavosertib",
    "resource" : {
      "resourceType" : "MedicationRequest",
      "id" : "mii-exa-mtb-medication-request-adavosertib",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "draft",
      "intent" : "option",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fdasis.nlm.nih.gov",
          "code" : "K2T6HJX3I3",
          "display" : "ADAVOSERTIB"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "authoredOn" : "2023-03-28",
      "reasonReference" : [{
        "reference" : "Condition/PatientKimMusterperson-PrimaryDiagnosis-2"
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationRequest/mii-exa-mtb-medication-request-adavosertib"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationRequest/mii-exa-mtb-medication-request-carboplatin",
    "resource" : {
      "resourceType" : "MedicationRequest",
      "id" : "mii-exa-mtb-medication-request-carboplatin",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "draft",
      "intent" : "option",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fhir.de/CodeSystem/bfarm/atc",
          "version" : "2025",
          "code" : "L01XA02",
          "display" : "Carboplatin"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "authoredOn" : "2023-03-28",
      "reasonReference" : [{
        "reference" : "Condition/PatientKimMusterperson-PrimaryDiagnosis-2"
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationRequest/mii-exa-mtb-medication-request-carboplatin"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/RequestGroup/mii-exa-mtb-request-group-adavosertib-carboplatin",
    "resource" : {
      "resourceType" : "RequestGroup",
      "id" : "mii-exa-mtb-request-group-adavosertib-carboplatin",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung-kombination|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "extensions"
      },
      "extension" : [{
        "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-prioritaet",
        "valuePositiveInt" : 4
      },
      {
        "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-evidenzgraduierung",
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-empfehlung-evidenzgrad",
            "code" : "m1B"
          }]
        }
      },
      {
        "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-publikation",
        "valueIdentifier" : {
          "system" : "http://www.ncbi.nlm.nih.gov/pubmed",
          "value" : "37236033"
        }
      }],
      "status" : "draft",
      "intent" : "proposal",
      "code" : {
        "coding" : [{
          "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-therapie-typ",
          "code" : "CZ",
          "display" : "Chemotherapie + zielgerichtete Substanzen"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "authoredOn" : "2023-03-28",
      "action" : [{
        "resource" : {
          "reference" : "MedicationRequest/mii-exa-mtb-medication-request-carboplatin"
        }
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "RequestGroup/mii-exa-mtb-request-group-adavosertib-carboplatin"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationRequest/mii-exa-mtb-medication-request-lunresertib",
    "resource" : {
      "resourceType" : "MedicationRequest",
      "id" : "mii-exa-mtb-medication-request-lunresertib",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "draft",
      "intent" : "option",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fdasis.nlm.nih.gov",
          "code" : "N95U3A7N57",
          "display" : "LUNRESERTIB"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "authoredOn" : "2023-03-28",
      "reasonReference" : [{
        "reference" : "Condition/PatientKimMusterperson-PrimaryDiagnosis-2"
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationRequest/mii-exa-mtb-medication-request-lunresertib"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationRequest/mii-exa-mtb-medication-request-camonsertib",
    "resource" : {
      "resourceType" : "MedicationRequest",
      "id" : "mii-exa-mtb-medication-request-camonsertib",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "draft",
      "intent" : "option",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fdasis.nlm.nih.gov",
          "code" : "S1Z7Y5G56T",
          "display" : "CAMONSERTIB"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "authoredOn" : "2023-03-28",
      "reasonReference" : [{
        "reference" : "Condition/PatientKimMusterperson-PrimaryDiagnosis-2"
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationRequest/mii-exa-mtb-medication-request-camonsertib"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/RequestGroup/mii-exa-mtb-request-group-lunresertib-camonsertib",
    "resource" : {
      "resourceType" : "RequestGroup",
      "id" : "mii-exa-mtb-request-group-lunresertib-camonsertib",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung-kombination|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "extensions"
      },
      "extension" : [{
        "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-prioritaet",
        "valuePositiveInt" : 5
      },
      {
        "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-evidenzgraduierung",
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-empfehlung-evidenzgrad",
            "code" : "m1B"
          }]
        }
      },
      {
        "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-publikation",
        "valueIdentifier" : {
          "system" : "http://doi.org",
          "value" : "10.1158/1535-7163.TARG-23-PR008"
        }
      }],
      "status" : "draft",
      "intent" : "proposal",
      "code" : {
        "coding" : [{
          "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-therapie-typ",
          "code" : "ZS",
          "display" : "zielgerichtete Substanzen"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "authoredOn" : "2023-03-28",
      "action" : [{
        "resource" : {
          "reference" : "MedicationRequest/mii-exa-mtb-medication-request-camonsertib"
        }
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "RequestGroup/mii-exa-mtb-request-group-lunresertib-camonsertib"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/MedicationRequest/mii-exa-mtb-medication-request-cobimetinib",
    "resource" : {
      "resourceType" : "MedicationRequest",
      "id" : "mii-exa-mtb-medication-request-cobimetinib",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "extensions"
      },
      "extension" : [{
        "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-prioritaet",
        "valuePositiveInt" : 6
      },
      {
        "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-evidenzgraduierung",
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-empfehlung-evidenzgrad",
            "code" : "m3"
          }]
        }
      },
      {
        "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-publikation",
        "valueIdentifier" : {
          "system" : "http://www.ncbi.nlm.nih.gov/pubmed",
          "value" : "31209687"
        }
      }],
      "status" : "draft",
      "intent" : "option",
      "medicationCodeableConcept" : {
        "coding" : [{
          "system" : "http://fdasis.nlm.nih.gov",
          "code" : "ER29L26N1X",
          "display" : "COBIMETINIB"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "authoredOn" : "2023-03-28",
      "reasonReference" : [{
        "reference" : "Condition/PatientKimMusterperson-PrimaryDiagnosis-2"
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "MedicationRequest/mii-exa-mtb-medication-request-cobimetinib"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/CarePlan/mii-exa-mtb-kim-musterperson-therapieplan",
    "resource" : {
      "resourceType" : "CarePlan",
      "id" : "mii-exa-mtb-kim-musterperson-therapieplan",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieplan|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "active",
      "intent" : "plan",
      "category" : [{
        "coding" : [{
          "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-therapieplanung-typ",
          "code" : "praeth"
        }]
      }],
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "created" : "2023-03-28",
      "addresses" : [{
        "reference" : "Condition/PatientKimMusterperson-PrimaryDiagnosis-2"
      }],
      "supportingInfo" : [{
        "reference" : "ClinicalImpression/mii-exa-mtb-kim-musterperson-behandlungsepisode"
      }],
      "activity" : [{
        "outcomeReference" : [{
          "reference" : "Procedure/MTBChemo2Procedure"
        }],
        "reference" : {
          "reference" : "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
        }
      },
      {
        "reference" : {
          "reference" : "ServiceRequest/mii-exa-mtb-study-request-cldn6"
        }
      },
      {
        "reference" : {
          "reference" : "ServiceRequest/mii-exa-mtb-study-request-tedova"
        }
      },
      {
        "reference" : {
          "reference" : "ServiceRequest/mii-exa-mtb-study-request-ccne1"
        }
      },
      {
        "reference" : {
          "reference" : "MedicationRequest/mii-exa-mtb-medication-request-trastuzumab-deruxtecan"
        }
      },
      {
        "reference" : {
          "reference" : "RequestGroup/mii-exa-mtb-request-group-adavosertib-carboplatin"
        }
      },
      {
        "reference" : {
          "reference" : "RequestGroup/mii-exa-mtb-request-group-lunresertib-camonsertib"
        }
      },
      {
        "reference" : {
          "reference" : "MedicationRequest/mii-exa-mtb-medication-request-cobimetinib"
        }
      },
      {
        "reference" : {
          "reference" : "ServiceRequest/mii-exa-mtb-kim-humangenetische-beratung-aszites"
        }
      },
      {
        "reference" : {
          "reference" : "ServiceRequest/mii-exa-mtb-kim-histologie-evaluation-aszites"
        }
      },
      {
        "reference" : {
          "reference" : "ServiceRequest/mii-exa-mtb-kim-rebiopsie-aszites"
        }
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "CarePlan/mii-exa-mtb-kim-musterperson-therapieplan"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/mii-exa-mtb-kim-tumorzellgehalt-aszites",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "mii-exa-mtb-kim-tumorzellgehalt-aszites",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-tumorzellgehalt|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "93356-4",
          "display" : "Cells with cytogenetic abnormality [#] in Blood or Tissue by Molecular genetics method"
        }]
      },
      "valueQuantity" : {
        "value" : 0.028,
        "system" : "http://unitsofmeasure.org",
        "code" : "%"
      },
      "method" : {
        "coding" : [{
          "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-bestimmungsmethode-tumorzellgehalt",
          "code" : "histologic"
        }]
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/mii-exa-mtb-kim-tumorzellgehalt-aszites"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/ServiceRequest/mii-exa-mtb-kim-humangenetische-beratung-aszites",
    "resource" : {
      "resourceType" : "ServiceRequest",
      "id" : "mii-exa-mtb-kim-humangenetische-beratung-aszites",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-humangenetische-beratung-auftrag|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "completed",
      "intent" : "proposal",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "788339009",
          "display" : "Genetic consultation (procedure)"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "reasonCode" : [{
        "coding" : [{
          "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-auftrag-begruendung",
          "code" : "secondary-tumor"
        }]
      }],
      "specimen" : [{
        "reference" : "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "ServiceRequest/mii-exa-mtb-kim-humangenetische-beratung-aszites"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/ServiceRequest/mii-exa-mtb-kim-histologie-evaluation-aszites",
    "resource" : {
      "resourceType" : "ServiceRequest",
      "id" : "mii-exa-mtb-kim-histologie-evaluation-aszites",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-histologie-evaluation-auftrag|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "draft",
      "intent" : "proposal",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "183825009",
          "display" : "Refer for histology (procedure)"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "reasonReference" : [{
        "reference" : "Observation/mii-exa-mtb-kim-tumorzellgehalt-aszites"
      }],
      "specimen" : [{
        "reference" : "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "ServiceRequest/mii-exa-mtb-kim-histologie-evaluation-aszites"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/ServiceRequest/mii-exa-mtb-kim-rebiopsie-aszites",
    "resource" : {
      "resourceType" : "ServiceRequest",
      "id" : "mii-exa-mtb-kim-rebiopsie-aszites",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-biopsie-auftrag|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "completed",
      "intent" : "proposal",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "86273004",
          "display" : "Biopsy (procedure)"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "reasonReference" : [{
        "reference" : "Observation/mii-exa-mtb-kim-tumorzellgehalt-aszites"
      }],
      "specimen" : [{
        "reference" : "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "ServiceRequest/mii-exa-mtb-kim-rebiopsie-aszites"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Condition/mii-exa-mtb-kim-diagnose",
    "resource" : {
      "resourceType" : "Condition",
      "id" : "mii-exa-mtb-kim-diagnose",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-diagnose-primaertumor|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "extensions"
      },
      "extension" : [{
        "url" : "http://hl7.org/fhir/StructureDefinition/condition-assertedDate",
        "valueDateTime" : "2021-06-10"
      }],
      "clinicalStatus" : {
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/condition-clinical",
          "code" : "active"
        }]
      },
      "verificationStatus" : {
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/condition-ver-status",
          "code" : "unconfirmed"
        },
        {
          "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-primaertumor-diagnosesicherung",
          "code" : "2"
        }]
      },
      "category" : [{
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "55342001",
          "display" : "Neoplastic disease"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://fhir.de/CodeSystem/bfarm/icd-10-gm",
          "version" : "2023",
          "code" : "C48.2",
          "display" : "Bösartige Neubildung: Peritoneum, nicht näher bezeichnet"
        }]
      },
      "bodySite" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/icd-o-3",
          "code" : "C56.9",
          "display" : "Ovar"
        }]
      }],
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "recordedDate" : "2021-06-10",
      "stage" : [{
        "assessment" : [{
          "reference" : "Observation/mii-exa-mtb-kim-tumorausbreitung"
        }],
        "type" : {
          "coding" : [{
            "system" : "https://nih-ncpi.github.io/ncpi-fhir-ig/CodeSystem-ncit.html",
            "code" : "C19251",
            "display" : "Stage at Diagnosis"
          }]
        }
      },
      {
        "assessment" : [{
          "reference" : "Observation/mii-exa-mtb-kim-oncotree"
        }],
        "type" : {
          "coding" : [{
            "system" : "http://snomed.info/sct",
            "code" : "371441004",
            "display" : "Histologic type of proliferative mass"
          }]
        }
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "Condition/mii-exa-mtb-kim-diagnose"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/mii-exa-mtb-kim-tumorausbreitung",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "mii-exa-mtb-kim-tumorausbreitung",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-tumorausbreitung|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "473302008",
          "display" : "Aware of diagnosis"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "371508000",
          "display" : "Tumor stage"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2021-06-10",
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "255127006"
        }]
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/mii-exa-mtb-kim-tumorausbreitung"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/mii-exa-mtb-kim-oncotree",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "mii-exa-mtb-kim-oncotree",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-oncotree|2027.0.0-ballot.1"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "371469007",
          "display" : "Histologic grade of neoplasm (observable entity)"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "effectiveDateTime" : "2021-06-10",
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://data.mskcc.org/ontologies/oncotree",
          "code" : "HGONEC"
        }]
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/mii-exa-mtb-kim-oncotree"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Condition/PatientKimMusterperson-PrimaryDiagnosis-2",
    "resource" : {
      "resourceType" : "Condition",
      "id" : "PatientKimMusterperson-PrimaryDiagnosis-2",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-diagnose-primaertumor"]
      },
      "language" : "de",
      "text" : {
        "status" : "extensions"
      },
      "extension" : [{
        "url" : "http://hl7.org/fhir/StructureDefinition/condition-assertedDate",
        "valueDateTime" : "2021-06-10"
      }],
      "clinicalStatus" : {
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/condition-clinical",
          "code" : "active"
        }]
      },
      "verificationStatus" : {
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/condition-ver-status",
          "code" : "unconfirmed"
        },
        {
          "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-primaertumor-diagnosesicherung",
          "code" : "2"
        }]
      },
      "category" : [{
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "55342001",
          "display" : "Neoplastic disease"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://fhir.de/CodeSystem/bfarm/icd-10-gm",
          "version" : "2020",
          "code" : "C48.2",
          "display" : "Bösartige Neubildung: Peritoneum, nicht näher bezeichnet"
        }]
      },
      "bodySite" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/icd-o-3",
          "code" : "C56.9",
          "display" : "Ovar"
        }]
      }],
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "recordedDate" : "2021-06-10"
    },
    "request" : {
      "method" : "PUT",
      "url" : "Condition/PatientKimMusterperson-PrimaryDiagnosis-2"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Observation/mii-exa-onko-allgemeiner-leistungszustand-ecog",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "mii-exa-onko-allgemeiner-leistungszustand-ecog",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-allgemeiner-leistungszustand-ecog"]
      },
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "final",
      "code" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "423740007"
        }]
      },
      "subject" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-allgemeiner-leistungszustand-ecog",
          "code" : "2",
          "display" : "Gehfähig, Selbstversorgung möglich, aber nicht arbeitsfähig; kann mehr als 50 % der Wachzeit aufstehen (50 - 60 % nach Karnofsky)"
        }]
      }
    },
    "request" : {
      "method" : "PUT",
      "url" : "Observation/mii-exa-onko-allgemeiner-leistungszustand-ecog"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Organization/MyHospital",
    "resource" : {
      "resourceType" : "Organization",
      "id" : "MyHospital",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "type" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/organization-type",
          "code" : "prov",
          "display" : "Healthcare Provider"
        }]
      }],
      "name" : "Example General Hospital",
      "address" : [{
        "line" : ["1234 Health St"],
        "city" : "Medicity",
        "state" : "CareState",
        "postalCode" : "12345",
        "country" : "DE"
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "Organization/MyHospital"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Organization/MyInsurer",
    "resource" : {
      "resourceType" : "Organization",
      "id" : "MyInsurer",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "type" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/organization-type",
          "code" : "ins",
          "display" : "Insurance Company"
        }]
      }],
      "name" : "Example Health Insurance Co.",
      "address" : [{
        "line" : ["789 Insurance Blvd"],
        "city" : "Policytown",
        "state" : "InsureState",
        "postalCode" : "98765",
        "country" : "DE"
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "Organization/MyInsurer"
    }
  },
  {
    "fullUrl" : "http://example.org/fhir/Coverage/MyCoverage",
    "resource" : {
      "resourceType" : "Coverage",
      "id" : "MyCoverage",
      "language" : "de",
      "text" : {
        "status" : "generated"
      },
      "status" : "active",
      "type" : {
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/v3-ActCode",
          "code" : "EHCPOL",
          "display" : "extended healthcare"
        }]
      },
      "beneficiary" : {
        "reference" : "Patient/PatientKimMusterperson"
      },
      "period" : {
        "start" : "2023-01-01",
        "end" : "2025-12-31"
      },
      "payor" : [{
        "reference" : "Organization/MyInsurer"
      }]
    },
    "request" : {
      "method" : "PUT",
      "url" : "Coverage/MyCoverage"
    }
  }]
}