MII IG Kerndatensatz-Modul Molekulares Tumorboard
2027.0.0-ballot.1 -
Germany
MII IG Kerndatensatz-Modul Molekulares Tumorboard
2027.0.0-ballot.1 -
Germany
This page is part of the MII Implementation Guide Molecular Tumor Board (v2027.0.0-ballot.1: Release) based on FHIR (HL7® FHIR® Standard) R4. This is the current published version. For a full list of available versions, see the Directory of published versions
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<subject>🔗
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<supportingInfo>🔗
<reference
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<supportingInfo>🔗
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<language value="de"/>
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<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
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<Patient>
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<language value="de"/>
<text>
<status value="generated"/>
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<name>
<family value="Musterperson"/>
<given value="Kim"/>
</name>
<birthDate value="1956-03-14"/>
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<method value="PUT"/>
<url value="Patient/PatientKimMusterperson"/>
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<text>
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<category>
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<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
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<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
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<url value="Observation/MTBObservationCA125-2"/>
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<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
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<url value="Observation/MTBObservationCA125-3"/>
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<language value="de"/>
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<status value="generated"/>
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<category>
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<reference value="Patient/PatientKimMusterperson"/>
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<category>
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<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
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<effectiveDateTime value="2023-06-20"/>
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<url value="Observation/MTBObservationCA125-6"/>
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<entry>
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<id value="PatientKimMusterperson-MolecularPathologyReport-1"/>
<meta>
<profile
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<language value="de"/>
<text>
<status value="generated"/>
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<status value="final"/>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="60568-3"/>
<display value="Pathology synoptic report"/>
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<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<result>🔗
<reference
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</result>
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<request>
<method value="PUT"/>
<url
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<entry>
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<resource>
<Specimen>
<id value="PatientKimMusterperson-AscitesSpecimen-2"/>
<meta>
<profile
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<language value="de"/>
<text>
<status value="generated"/>
</text>
<accessionIdentifier>
<value value="Z230201/23"/>
</accessionIdentifier>
<type>
<coding>
<system value="http://snomed.info/sct"/>
<code value="309201001"/>
<display value="Ascitic fluid specimen (specimen)"/>
</coding>
</type>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<collection>
<collectedDateTime value="2023-02-01"/>
</collection>
</Specimen>
</resource>
<request>
<method value="PUT"/>
<url value="Specimen/PatientKimMusterperson-AscitesSpecimen-2"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-0a-Her2neu"/>
<resource>
<Observation>
<id
value="PatientKimMusterperson-MolecularPathologyObservation-0a-Her2neu"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<category>
<coding>
<system
value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
<code value="biomarker-category"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="18474-7"/>
<display value="HER2 Ag [Presence] in Tissue by Immune stain"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="1234806008"/>
<display
value="Observation using immunohistochemistry (observable entity)"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<valueCodeableConcept>
<coding>
<system value="http://loinc.org"/>
<code value="LA11842-4"/>
<display value="2+"/>
</coding>
</valueCodeableConcept>
<specimen>🔗
<reference
value="Specimen/PatientKimMusterperson-AscitesSpecimen-2"/>
</specimen>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
<display value="Gene studied [ID]"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org/geneId"/>
<code value="HGNC:3430"/>
<display value="ERBB2"/>
</coding>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url
value="Observation/PatientKimMusterperson-MolecularPathologyObservation-0a-Her2neu"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyInterpret-0a-Her2neu"/>
<resource>
<Observation>
<id
value="PatientKimMusterperson-MolecularPathologyInterpret-0a-Her2neu"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system
value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
<code value="biomarker-category"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48676-1"/>
<display value="HER2 Ag [Interpretation] in Tissue"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="1234806008"/>
<display
value="Observation using immunohistochemistry (observable entity)"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="1381317004"/>
<display value="Human epidermal growth factor receptor 2 low"/>
</coding>
<text value="HER2-low (IHC 2+/ISH negative)"/>
</valueCodeableConcept>
<specimen>🔗
<reference
value="Specimen/PatientKimMusterperson-AscitesSpecimen-2"/>
</specimen>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
<display value="Gene studied [ID]"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org/geneId"/>
<code value="HGNC:3430"/>
<display value="ERBB2"/>
</coding>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url
value="Observation/PatientKimMusterperson-MolecularPathologyInterpret-0a-Her2neu"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-0b-Folat-Ra"/>
<resource>
<Observation>
<id
value="PatientKimMusterperson-MolecularPathologyObservation-0b-Folat-Ra"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system
value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
<code value="biomarker-category"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="55229-9"/>
<display value="Immune stain study"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="1234806008"/>
<display
value="Observation using immunohistochemistry (observable entity)"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<valueQuantity>
<value value="70"/>
<unit value="%"/>
<system value="http://unitsofmeasure.org"/>
<code value="{/100}"/>
</valueQuantity>
<specimen>🔗
<reference
value="Specimen/PatientKimMusterperson-AscitesSpecimen-2"/>
</specimen>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
<display value="Gene studied [ID]"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org/geneId"/>
<code value="HGNC:3791"/>
<display value="FOLR1"/>
</coding>
<coding>
<system value="http://loinc.org"/>
<code value="LP440974-6"/>
<display value="Folate receptor alpha"/>
</coding>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url
value="Observation/PatientKimMusterperson-MolecularPathologyObservation-0b-Folat-Ra"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-0c-Trop2"/>
<resource>
<Observation>
<id
value="PatientKimMusterperson-MolecularPathologyObservation-0c-Trop2"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system
value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
<code value="biomarker-category"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="55229-9"/>
<display value="Immune stain study"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="1234806008"/>
<display
value="Observation using immunohistochemistry (observable entity)"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<valueCodeableConcept>
<coding>
<system value="http://loinc.org"/>
<code value="LA6576-8"/>
<display value="Positive"/>
</coding>
</valueCodeableConcept>
<specimen>🔗
<reference
value="Specimen/PatientKimMusterperson-AscitesSpecimen-2"/>
</specimen>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
<display value="Gene studied [ID]"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org/geneId"/>
<code value="HGNC:11530"/>
<display value="TACSTD2"/>
</coding>
<coding>
<system value="http://www.uniprot.org"/>
<code value="P09758"/>
<display value="Tumor-associated calcium signal transducer 2"/>
</coding>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url
value="Observation/PatientKimMusterperson-MolecularPathologyObservation-0c-Trop2"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-1-CA125"/>
<resource>
<Observation>
<id
value="PatientKimMusterperson-MolecularPathologyObservation-1-CA125"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system
value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
<code value="biomarker-category"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48677-9"/>
<display
value="Cancer Ag 125 [Presence] in Tissue by Immune stain"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="1234806008"/>
<display
value="Observation using immunohistochemistry (observable entity)"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<valueCodeableConcept>
<coding>
<system value="http://loinc.org"/>
<code value="LA6576-8"/>
<display value="Positive"/>
</coding>
<text value="Die Tumorzellen sind partiell positiv für CA125,..."/>
</valueCodeableConcept>
<specimen>🔗
<reference
value="Specimen/PatientKimMusterperson-AscitesSpecimen-2"/>
</specimen>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
<display value="Gene studied [ID]"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org/geneId"/>
<code value="HGNC:11530"/>
<display value="TACSTD2"/>
</coding>
<coding>
<system value="http://www.uniprot.org"/>
<code value="P09758"/>
<display value="Tumor-associated calcium signal transducer 2"/>
</coding>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url
value="Observation/PatientKimMusterperson-MolecularPathologyObservation-1-CA125"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-2-Pax8"/>
<resource>
<Observation>
<id
value="PatientKimMusterperson-MolecularPathologyObservation-2-Pax8"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system
value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
<code value="biomarker-category"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="73910-2"/>
<display value="PAX8 Ag [Presence] in Tissue by Immune stain"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="1234806008"/>
<display
value="Observation using immunohistochemistry (observable entity)"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<valueCodeableConcept>
<coding>
<system value="http://loinc.org"/>
<code value="LA6576-8"/>
<display value="Positive"/>
</coding>
<text value="Tumorzellen durchgehend nukleär für Pax 8"/>
</valueCodeableConcept>
<specimen>🔗
<reference
value="Specimen/PatientKimMusterperson-AscitesSpecimen-2"/>
</specimen>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url
value="Observation/PatientKimMusterperson-MolecularPathologyObservation-2-Pax8"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-3-WT1"/>
<resource>
<Observation>
<id
value="PatientKimMusterperson-MolecularPathologyObservation-3-WT1"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system
value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
<code value="biomarker-category"/>
</coding>
</category>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="1234806008"/>
<display
value="Observation using immunohistochemistry (observable entity)"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<valueCodeableConcept>
<coding>
<system value="http://loinc.org"/>
<code value="LA6576-8"/>
<display value="Positive"/>
</coding>
<text value="Tumorzellen durchgehend nukleär für WT1"/>
</valueCodeableConcept>
<bodySite>
<coding>
<system value="http://snomed.info/sct"/>
<code value="84640000"/>
<display value="Nucleus (cell structure)"/>
</coding>
<text value="Nukleär"/>
</bodySite>
<specimen>🔗
<reference
value="Specimen/PatientKimMusterperson-AscitesSpecimen-2"/>
</specimen>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
<display value="Gene studied [ID]"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org/geneId"/>
<code value="HGNC:12796"/>
<display value="WT1"/>
</coding>
<coding>
<system value="http://loinc.org"/>
<code value="LP65352-4"/>
<display value="WT-1 Ag"/>
</coding>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url
value="Observation/PatientKimMusterperson-MolecularPathologyObservation-3-WT1"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-4-ER"/>
<resource>
<Observation>
<id
value="PatientKimMusterperson-MolecularPathologyObservation-4-ER"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system
value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
<code value="biomarker-category"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="14228-1"/>
<display
value="Cells.estrogen receptor/cells in Tissue by Immune stain"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="1234806008"/>
<display
value="Observation using immunohistochemistry (observable entity)"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<valueQuantity>
<value value="70"/>
<unit value="%"/>
<system value="http://unitsofmeasure.org"/>
<code value="/100"/>
</valueQuantity>
<specimen>🔗
<reference
value="Specimen/PatientKimMusterperson-AscitesSpecimen-2"/>
</specimen>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url
value="Observation/PatientKimMusterperson-MolecularPathologyObservation-4-ER"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-5-PR"/>
<resource>
<Observation>
<id
value="PatientKimMusterperson-MolecularPathologyObservation-5-PR"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system
value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
<code value="biomarker-category"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="14230-7"/>
<display
value="Cells.progesterone receptor/cells in Tissue by Immune stain"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="1234806008"/>
<display
value="Observation using immunohistochemistry (observable entity)"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<valueQuantity>
<value value="30"/>
<unit value="%"/>
<system value="http://unitsofmeasure.org"/>
<code value="/100"/>
</valueQuantity>
<specimen>🔗
<reference
value="Specimen/PatientKimMusterperson-AscitesSpecimen-2"/>
</specimen>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url
value="Observation/PatientKimMusterperson-MolecularPathologyObservation-5-PR"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-6-p53"/>
<resource>
<Observation>
<id
value="PatientKimMusterperson-MolecularPathologyObservation-6-p53"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system
value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
<code value="biomarker-category"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="14229-9"/>
<display
value="P53 protein Ag [Presence] in Tissue by Immune stain"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="1234806008"/>
<display
value="Observation using immunohistochemistry (observable entity)"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<valueCodeableConcept>
<coding>
<system value="http://loinc.org"/>
<code value="LA6576-8"/>
<display value="Positive"/>
</coding>
<text value="Kräftige nukleäre Überexpression von p53"/>
</valueCodeableConcept>
<specimen>🔗
<reference
value="Specimen/PatientKimMusterperson-AscitesSpecimen-2"/>
</specimen>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url
value="Observation/PatientKimMusterperson-MolecularPathologyObservation-6-p53"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-7-p53"/>
<resource>
<Observation>
<id
value="PatientKimMusterperson-MolecularPathologyObservation-7-p53"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system
value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
<code value="biomarker-category"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="14229-9"/>
<display
value="P53 protein Ag [Presence] in Tissue by Immune stain"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="1234806008"/>
<display
value="Observation using immunohistochemistry (observable entity)"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<valueCodeableConcept>
<coding>
<system value="http://loinc.org"/>
<code value="LA6576-8"/>
<display value="Positive"/>
</coding>
<text value="Kräftige nukleäre Überexpression von p53"/>
</valueCodeableConcept>
<specimen>🔗
<reference
value="Specimen/PatientKimMusterperson-AscitesSpecimen-2"/>
</specimen>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url
value="Observation/PatientKimMusterperson-MolecularPathologyObservation-7-p53"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Procedure/PatientKimMusterperson-Procedure-1"/>
<resource>
<Procedure>
<id value="PatientKimMusterperson-Procedure-1"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/core/modul-prozedur/StructureDefinition/Procedure"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="completed"/>
<category>
<coding>
<system value="http://snomed.info/sct"/>
<code value="363680008"/>
<display value="Radiographic imaging procedure"/>
</coding>
</category>
<code>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/ops"/>
<version value="2025"/>
<code value="3-20"/>
<display value="Computertomographie [CT], nativ"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<performedDateTime value="2022-04-20"/>
<bodySite>
<coding>
<system value="http://snomed.info/sct"/>
<code value="818983003"/>
<display value="Abdomen"/>
</coding>
</bodySite>
<bodySite>
<coding>
<system value="http://snomed.info/sct"/>
<code value="51185008"/>
<display value="Thoracic structure"/>
</coding>
</bodySite>
</Procedure>
</resource>
<request>
<method value="PUT"/>
<url value="Procedure/PatientKimMusterperson-Procedure-1"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Procedure/PatientKimMusterperson-Procedure-2"/>
<resource>
<Procedure>
<id value="PatientKimMusterperson-Procedure-2"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/core/modul-prozedur/StructureDefinition/Procedure"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="completed"/>
<category>
<coding>
<system value="http://snomed.info/sct"/>
<code value="363680008"/>
<display value="Radiographic imaging procedure"/>
</coding>
</category>
<code>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/ops"/>
<version value="2025"/>
<code value="3-20"/>
<display value="Computertomographie [CT], nativ"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<performedDateTime value="2022-07-15"/>
<bodySite>
<coding>
<system value="http://snomed.info/sct"/>
<code value="818983003"/>
<display value="Abdomen"/>
</coding>
</bodySite>
<bodySite>
<coding>
<system value="http://snomed.info/sct"/>
<code value="51185008"/>
<display value="Thoracic structure"/>
</coding>
</bodySite>
</Procedure>
</resource>
<request>
<method value="PUT"/>
<url value="Procedure/PatientKimMusterperson-Procedure-2"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Procedure/PatientKimMusterperson-Procedure-3"/>
<resource>
<Procedure>
<id value="PatientKimMusterperson-Procedure-3"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/core/modul-prozedur/StructureDefinition/Procedure"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="completed"/>
<category>
<coding>
<system value="http://snomed.info/sct"/>
<code value="363680008"/>
<display value="Radiographic imaging procedure"/>
</coding>
</category>
<code>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/ops"/>
<version value="2025"/>
<code value="3-20"/>
<display value="Computertomographie [CT], nativ"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<performedDateTime value="2022-10-22"/>
<bodySite>
<coding>
<system value="http://snomed.info/sct"/>
<code value="818983003"/>
<display value="Abdomen"/>
</coding>
</bodySite>
<bodySite>
<coding>
<system value="http://snomed.info/sct"/>
<code value="51185008"/>
<display value="Thoracic structure"/>
</coding>
</bodySite>
</Procedure>
</resource>
<request>
<method value="PUT"/>
<url value="Procedure/PatientKimMusterperson-Procedure-3"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Procedure/PatientKimMusterperson-Procedure-4"/>
<resource>
<Procedure>
<id value="PatientKimMusterperson-Procedure-4"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/core/modul-prozedur/StructureDefinition/Procedure"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="completed"/>
<category>
<coding>
<system value="http://snomed.info/sct"/>
<code value="363680008"/>
<display value="Radiographic imaging procedure"/>
</coding>
</category>
<code>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/ops"/>
<version value="2025"/>
<code value="3-20"/>
<display value="Computertomographie [CT], nativ"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<performedDateTime value="2022-12-19"/>
<bodySite>
<coding>
<system value="http://snomed.info/sct"/>
<code value="818983003"/>
<display value="Abdomen"/>
</coding>
</bodySite>
<bodySite>
<coding>
<system value="http://snomed.info/sct"/>
<code value="51185008"/>
<display value="Thoracic structure"/>
</coding>
</bodySite>
</Procedure>
</resource>
<request>
<method value="PUT"/>
<url value="Procedure/PatientKimMusterperson-Procedure-4"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Procedure/PatientKimMusterperson-Procedure-5"/>
<resource>
<Procedure>
<id value="PatientKimMusterperson-Procedure-5"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/core/modul-prozedur/StructureDefinition/Procedure"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="completed"/>
<category>
<coding>
<system value="http://snomed.info/sct"/>
<code value="363680008"/>
<display value="Radiographic imaging procedure"/>
</coding>
</category>
<code>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/ops"/>
<version value="2025"/>
<code value="3-20"/>
<display value="Computertomographie [CT], nativ"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<performedDateTime value="2023-03-20"/>
<bodySite>
<coding>
<system value="http://snomed.info/sct"/>
<code value="818983003"/>
<display value="Abdomen"/>
</coding>
</bodySite>
<bodySite>
<coding>
<system value="http://snomed.info/sct"/>
<code value="51185008"/>
<display value="Thoracic structure"/>
</coding>
</bodySite>
</Procedure>
</resource>
<request>
<method value="PUT"/>
<url value="Procedure/PatientKimMusterperson-Procedure-5"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Procedure/PatientKimMusterperson-Procedure-6"/>
<resource>
<Procedure>
<id value="PatientKimMusterperson-Procedure-6"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/core/modul-prozedur/StructureDefinition/Procedure"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="completed"/>
<category>
<coding>
<system value="http://snomed.info/sct"/>
<code value="363680008"/>
<display value="Radiographic imaging procedure"/>
</coding>
</category>
<code>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/ops"/>
<version value="2025"/>
<code value="3-20"/>
<display value="Computertomographie [CT], nativ"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<performedDateTime value="2023-08-20"/>
<bodySite>
<coding>
<system value="http://snomed.info/sct"/>
<code value="818983003"/>
<display value="Abdomen"/>
</coding>
</bodySite>
<bodySite>
<coding>
<system value="http://snomed.info/sct"/>
<code value="51185008"/>
<display value="Thoracic structure"/>
</coding>
</bodySite>
</Procedure>
</resource>
<request>
<method value="PUT"/>
<url value="Procedure/PatientKimMusterperson-Procedure-6"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Procedure/PatientKimMusterperson-Procedure-7"/>
<resource>
<Procedure>
<id value="PatientKimMusterperson-Procedure-7"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/core/modul-prozedur/StructureDefinition/Procedure"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="completed"/>
<category>
<coding>
<system value="http://snomed.info/sct"/>
<code value="363680008"/>
<display value="Radiographic imaging procedure"/>
</coding>
</category>
<code>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/ops"/>
<version value="2025"/>
<code value="3-20"/>
<display value="Computertomographie [CT], nativ"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<performedDateTime value="2023-10-22"/>
<bodySite>
<coding>
<system value="http://snomed.info/sct"/>
<code value="818983003"/>
<display value="Abdomen"/>
</coding>
</bodySite>
<bodySite>
<coding>
<system value="http://snomed.info/sct"/>
<code value="51185008"/>
<display value="Thoracic structure"/>
</coding>
</bodySite>
</Procedure>
</resource>
<request>
<method value="PUT"/>
<url value="Procedure/PatientKimMusterperson-Procedure-7"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-1"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-1"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-1"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="128462008"/>
<display value="Metastatic malignant neoplasm (disorder)"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="41647002"/>
<display
value="No evidence of (contextual qualifier) (qualifier value)"/>
</coding>
<text value="kein Hinweis auf thorakale Metastasierung"/>
</valueCodeableConcept>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-1"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-2"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-2"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-1"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="255227004"/>
<display value="Recurrent"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="41647002"/>
<display
value="No evidence of (contextual qualifier) (qualifier value)"/>
</coding>
<text value="kein Hinweis auf Lokalrezidiv"/>
</valueCodeableConcept>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-2"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-3"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-3"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-1"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="389026000"/>
<display value="Ascites"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="860638000"/>
<display value="No ascites"/>
</coding>
<text value="kein Aszites"/>
</valueCodeableConcept>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-3"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-4"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-4"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-1"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="237679004"/>
<display
value="Status post (contextual qualifier) (qualifier value)"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="112231000"/>
<display value="Atypical (qualifier value)"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="174430004"/>
<display value="Resection of segment of liver (procedure)"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="309201001"/>
<display value="Ascitic fluid specimen"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="262061000"/>
<display value="After surgery"/>
</coding>
<text value="Flüssigkeitskollektion angrenzend DD postoperativ"/>
</valueCodeableConcept>
<bodySite>
<coding>
<system value="http://snomed.info/sct"/>
<code value="181247007"/>
<display value="Entire duodenum"/>
</coding>
</bodySite>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-4"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-5"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-5"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-2"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="237679004"/>
<display
value="Status post (contextual qualifier) (qualifier value)"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="112231000"/>
<display value="Atypical"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="174430004"/>
<display value="Resection of segment of liver (procedure)"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="420341009"/>
<display value="Constant"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="309201001"/>
<display value="Ascitic fluid specimen"/>
</coding>
<text value="konstante Flüssigkeitskollektion angrenzend"/>
</valueCodeableConcept>
<bodySite>
<coding>
<system value="http://snomed.info/sct"/>
<code value="181247007"/>
<display value="Entire duodenum"/>
</coding>
</bodySite>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-5"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-6"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-6"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-2"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="389026000"/>
<display value="Ascites"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="860638000"/>
<display value="No ascites"/>
</coding>
<text value="kein Aszites"/>
</valueCodeableConcept>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-6"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-7"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-7"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-2"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="255227004"/>
<display value="Recurrent"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="41647002"/>
<display
value="No evidence of (contextual qualifier) (qualifier value)"/>
</coding>
<text value="kein Hinweis auf Lokalrezidiv"/>
</valueCodeableConcept>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-7"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-8"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-8"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-2"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="112231000"/>
<display value="Atypical"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="1217294009"/>
<display value="Ground glass opacity"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="44714003"/>
<display value="Structure of upper lobe of left lung"/>
</coding>
<text
value="im linken Oberlappen der Lunge diskrete milchglasartige Trübung"/>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="41647002"/>
<display
value="No evidence of (contextual qualifier) (qualifier value)"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="255058005"/>
<display value="Neoplasm of thorax"/>
</coding>
<text value="kein Hinweis auf thorakale Filiae"/>
</valueCodeableConcept>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-8"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-9"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-9"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-3"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="237679004"/>
<display
value="Status post (contextual qualifier) (qualifier value)"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="112231000"/>
<display value="Atypical"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="174430004"/>
<display value="Resection of segment of liver (procedure)"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="309201001"/>
<display value="Ascitic fluid specimen"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="249567002"/>
<display value="Liver edge (finding)"/>
</coding>
<text value="regrediente Flüssigkeitskollektion am Leberrand"/>
</valueCodeableConcept>
<bodySite>
<coding>
<system value="http://snomed.info/sct"/>
<code value="181268008"/>
<display value="Entire liver"/>
</coding>
</bodySite>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-9"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-10"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-10"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-3"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="237679004"/>
<display
value="Status post (contextual qualifier) (qualifier value)"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="112231000"/>
<display value="Atypical"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="174430004"/>
<display value="Resection of segment of liver (procedure)"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="94381002"/>
<display
value="Metastatic malignant neoplasm to liver (disorder)"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="41647002"/>
<display
value="No evidence of (contextual qualifier) (qualifier value)"/>
</coding>
<text value="Darüberhinaus kein Hinweis auf Leberfilialisierung."/>
</valueCodeableConcept>
<bodySite>
<coding>
<system value="http://snomed.info/sct"/>
<code value="181268008"/>
<display value="Entire liver"/>
</coding>
</bodySite>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-10"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-11"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-11"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-3"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="389026000"/>
<display value="Ascites"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="860638000"/>
<display value="No ascites"/>
</coding>
<text value="kein Aszites"/>
</valueCodeableConcept>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-11"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-12"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-12"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-3"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="255227004"/>
<display value="Recurrent"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="41647002"/>
<display
value="No evidence of (contextual qualifier) (qualifier value)"/>
</coding>
<text value="kein Hinweis auf Lokalrezidiv"/>
</valueCodeableConcept>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-12"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-13"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-13"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-3"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="255227004"/>
<display value="Recurrent"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="1217294009"/>
<display value="Ground glass opacity"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="44714003"/>
<display value="Structure of upper lobe of left lung"/>
</coding>
<text value="regrediente Milchglasinfiltrate im linken Oberlappen"/>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="112231000"/>
<display value="Atypical"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="257552002"/>
<display value="Inflammation"/>
</coding>
<text value="a.e. atypisch entzündlich"/>
</valueCodeableConcept>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-13"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-14"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-14"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-3"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="245276004"/>
<display value="Mediastinal lymph node group"/>
</coding>
<text value="mediastinaler Lymphknoten"/>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="258283002"/>
<display value="Lymphomatous nodal involvement"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="373067005"/>
<display value="No"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="385420005"/>
<display value="Contrast media"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="151174005"/>
<display value="Drug intake observed"/>
</coding>
<text
value="vermehrter mediastinaler Lymphknotenbesatz ohne Kontrastmittelaufnahme"/>
</valueCodeableConcept>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-14"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-15"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-15"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-3"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="245276004"/>
<display value="Mediastinal lymph node group"/>
</coding>
<text value="mediastinaler Lymphknoten"/>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="373067005"/>
<display value="No"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="15454001"/>
<display value="Increased size"/>
</coding>
<text value="ohne pathologische Vergrößerung"/>
</valueCodeableConcept>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-15"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-16"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-16"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-4"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="255314001"/>
<display value="Progressive"/>
</coding>
<text value="Progredienter Aszites"/>
</code>
<valueQuantity>
<value value="700"/>
<unit value="ml"/>
<system value="http://unitsofmeasure.org"/>
<code value="mL"/>
</valueQuantity>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-16"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-17"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-17"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-4"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="362700006"/>
<display value="Entire peritoneal serous membrane of peritoneum"/>
</coding>
<text value="Peritonealblatt"/>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="385420005"/>
<display value="Contrast media"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="49608001"/>
<display value="Irregular"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="260366006"/>
<display value="Increase"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="151174005"/>
<display value="Drug intake observed"/>
</coding>
<text
value="Peritonealblatt mit zunehmender, unregelmäßiger KM-Aufnahme"/>
</valueCodeableConcept>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-17"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-18"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-18"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-4"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="836274002"/>
<display value="Carcinomatosis of peritoneum"/>
</coding>
<text value="Peritonealkarzinose"/>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="255314001"/>
<display value="Progressive"/>
</coding>
<text value="Progress"/>
</valueCodeableConcept>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-18"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-19"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-19"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-4"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="80266002"/>
<display value="True pelvis"/>
</coding>
<text value="kleinen Becken"/>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="255227004"/>
<display value="Recurrent"/>
</coding>
<text
value="Lokalrezidiv bei kontrastmittelaufnehmender Raumforderung"/>
</valueCodeableConcept>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-19"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-20"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-20"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-5"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="389026000"/>
<display value="Ascites"/>
</coding>
<text value="Aszites"/>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="37865006"/>
<display value="Regressive"/>
</coding>
<text value="Regredient"/>
</valueCodeableConcept>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-20"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-21"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-21"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-5"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="80266002"/>
<display value="True pelvis"/>
</coding>
<text value="im kleinen Becken"/>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="37865006"/>
<display value="Regressive"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="385420005"/>
<display value="Contrast media"/>
</coding>
<text
value="rückläufige KM-Aufnahme der lokalrezidivsuspekten Raumforderung"/>
</valueCodeableConcept>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-21"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-22"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-22"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-5"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="274744005"/>
<display value="Localized enlarged lymph nodes"/>
</coding>
<text value="zahlenmäßig vermehrten LK im Mediastinum"/>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="37865006"/>
<display value="Regressive"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="385420005"/>
<display value="Contrast media"/>
</coding>
<text value="noch flaue, aber insgesamt regrediente KM-Aufnhame"/>
</valueCodeableConcept>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-22"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-23"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-23"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-5"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="52988006"/>
<display value="Lesion"/>
</coding>
<text value="Läsion"/>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="373067005"/>
<display value="No"/>
</coding>
<text value="keine neue"/>
</valueCodeableConcept>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-23"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-24"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-24"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-6"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="389026000"/>
<display value="Ascites"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="860638000"/>
<display value="No ascites"/>
</coding>
<text value="kein Aszites"/>
</valueCodeableConcept>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-24"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-25"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-25"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-6"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="255227004"/>
<display value="Recurrent"/>
</coding>
<text value="Lokalrezidiv"/>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="37865006"/>
<display value="Regressive"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="373067005"/>
<display value="No"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="385420005"/>
<display value="Contrast media"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="151174005"/>
<display value="Drug intake observed"/>
</coding>
<text
value="regredientes Lokalrezidiv ohne KM-Aufnahme im kleinen Becken"/>
</valueCodeableConcept>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-25"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-26"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-26"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-7"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="80266002"/>
<display value="True pelvis"/>
</coding>
<text value="kleinen Becken"/>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="255606000"/>
<display value="Minor"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="389026000"/>
<display value="Ascites"/>
</coding>
<text value="geringer Aszites"/>
</valueCodeableConcept>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-26"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-27"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-27"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-7"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="237679004"/>
<display
value="Status post (contextual qualifier) (qualifier value)"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="246455001"/>
<display value="Recurrence"/>
</coding>
<text
value="vormals KM-aufnehmendes Lokalrezidiv im kleinen Becken"/>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="246455001"/>
<display value="Recurrence"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="263920009"/>
<display value="Unrecordable"/>
</coding>
<text value="aktuell metrisch nur noch schwer fassbar"/>
</valueCodeableConcept>
<bodySite>
<coding>
<system value="http://snomed.info/sct"/>
<code value="80266002"/>
<display value="True pelvis"/>
</coding>
</bodySite>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-27"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-29"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-29"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-7"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="245276004"/>
<display value="Mediastinal lymph node group"/>
</coding>
<text value="mediastinale Lymphknoten"/>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="35105006"/>
<display value="Increased"/>
</coding>
<text value="formal noch vermehrte"/>
</valueCodeableConcept>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-29"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/PatientKimMusterperson-Observation-30"/>
<resource>
<Observation>
<id value="PatientKimMusterperson-Observation-30"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/PatientKimMusterperson-Procedure-7"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="245276004"/>
<display value="Mediastinal lymph node group"/>
</coding>
<text value="mediastinale Lymphknoten"/>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="373067005"/>
<display value="No"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="385420005"/>
<display value="Contrast media"/>
</coding>
<coding>
<system value="http://snomed.info/sct"/>
<code value="151174005"/>
<display value="Drug intake observed"/>
</coding>
<text value="nicht mehr KM-aufnehmende"/>
</valueCodeableConcept>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/PatientKimMusterperson-Observation-30"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/ClinicalImpression/MII-EXA-MTB-Follow-Up-ClinicalImpression-1"/>
<resource>
<ClinicalImpression>
<id value="MII-EXA-MTB-Follow-Up-ClinicalImpression-1"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-follow-up-clinicalimpression|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="completed"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="390906007"/>
<display value="Follow-up encounter (procedure)"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2023-10-22"/>
<previous>🔗
<reference
value="ClinicalImpression/mii-exa-mtb-kim-musterperson-behandlungsepisode"/>
</previous>
<investigation>
<code>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-follow-up-status"/>
<code value="completed"/>
</coding>
</code>
</investigation>
<supportingInfo>🔗
<reference value="Procedure/MII-EXA-MTB-Systemische-Therapie-1"/>
</supportingInfo>
<supportingInfo>🔗
<reference value="Claim/MII-EXA-MTB-Antrag-Kostenuebernahme-1"/>
</supportingInfo>
<supportingInfo>🔗
<reference
value="ClaimResponse/MII-EXA-MTB-Antwort-Kostenuebernahme-1"/>
</supportingInfo>
</ClinicalImpression>
</resource>
<request>
<method value="PUT"/>
<url
value="ClinicalImpression/MII-EXA-MTB-Follow-Up-ClinicalImpression-1"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Procedure/MII-EXA-MTB-Systemische-Therapie-1"/>
<resource>
<Procedure>
<id value="MII-EXA-MTB-Systemische-Therapie-1"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-therapie|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="extensions"/>
</text>
<extension
url="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-ex-onko-systemische-therapie-intention">
<valueCodeableConcept>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-intention"/>
<code value="K"/>
</coding>
</valueCodeableConcept>
</extension>
<basedOn>🔗
<reference
value="CarePlan/mii-exa-mtb-kim-musterperson-therapieplan"/>
</basedOn>
<status value="completed"/>
<statusReason>
<coding>
<code value="regular-completion"/>
</coding>
</statusReason>
<category>
<coding>
<system value="http://snomed.info/sct"/>
<code value="367336001"/>
<display value="Chemotherapy (procedure)"/>
</coding>
</category>
<code>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-therapie-typ"/>
<code value="CH"/>
</coding>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/ops"/>
<version value="2023"/>
<code value="8-54"/>
<display
value="Zytostatische Chemotherapie, Immuntherapie und antiretrovirale Therapie"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<performedPeriod>
<start value="2023-06-24"/>
<end value="2023-10-12"/>
</performedPeriod>
</Procedure>
</resource>
<request>
<method value="PUT"/>
<url value="Procedure/MII-EXA-MTB-Systemische-Therapie-1"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-1"/>
<resource>
<MedicationStatement>
<id value="MII-EXA-MTB-Systemische-Therapie-Medication-1"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemtherapie-medication-statement"/>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-therapie-medication-statement|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<basedOn>🔗
<reference
value="MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"/>
</basedOn>
<partOf>🔗
<reference value="Procedure/MII-EXA-MTB-Systemische-Therapie-1"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<coding>
<system value="http://fdasis.nlm.nih.gov"/>
<code value="98DE7VN88D"/>
<display value="MIRVETUXIMAB SORAVTANSINE"/>
</coding>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<version value="2025"/>
<code value="L01FX26"/>
<display value="Mirvetuximab soravtansin"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectivePeriod>
<start value="2023-06-24"/>
<end value="2023-06-24"/>
</effectivePeriod>
<note>
<text
value="24.06.2023 Z1 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"/>
</note>
<dosage>
<timing>
<event value="2023-06-24"/>
</timing>
<doseAndRate>
<doseQuantity>
<value value="6"/>
<unit value="mg/kg KG"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg/kg{KG}"/>
</doseQuantity>
</doseAndRate>
</dosage>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url
value="MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-1"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-2"/>
<resource>
<MedicationStatement>
<id value="MII-EXA-MTB-Systemische-Therapie-Medication-2"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemtherapie-medication-statement"/>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-therapie-medication-statement|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<basedOn>🔗
<reference
value="MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"/>
</basedOn>
<partOf>🔗
<reference value="Procedure/MII-EXA-MTB-Systemische-Therapie-1"/>
</partOf>
<status value="completed"/>
<statusReason>
<coding>
<code value="E"/>
</coding>
</statusReason>
<medicationCodeableConcept>
<coding>
<system value="http://fdasis.nlm.nih.gov"/>
<code value="98DE7VN88D"/>
<display value="MIRVETUXIMAB SORAVTANSINE"/>
</coding>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<version value="2025"/>
<code value="L01FX26"/>
<display value="Mirvetuximab soravtansin"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectivePeriod>
<start value="2023-07-16"/>
<end value="2023-07-16"/>
</effectivePeriod>
<note>
<text
value="16.07.2023 Z2 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"/>
</note>
<dosage>
<timing>
<event value="2023-07-16"/>
</timing>
<doseAndRate>
<doseQuantity>
<value value="6"/>
<unit value="mg/kg KG"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg/kg{KG}"/>
</doseQuantity>
</doseAndRate>
</dosage>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url
value="MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-2"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-3"/>
<resource>
<MedicationStatement>
<id value="MII-EXA-MTB-Systemische-Therapie-Medication-3"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemtherapie-medication-statement"/>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-therapie-medication-statement|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<basedOn>🔗
<reference
value="MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"/>
</basedOn>
<partOf>🔗
<reference value="Procedure/MII-EXA-MTB-Systemische-Therapie-1"/>
</partOf>
<status value="completed"/>
<statusReason>
<coding>
<code value="E"/>
</coding>
</statusReason>
<medicationCodeableConcept>
<coding>
<system value="http://fdasis.nlm.nih.gov"/>
<code value="98DE7VN88D"/>
<display value="MIRVETUXIMAB SORAVTANSINE"/>
</coding>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<version value="2025"/>
<code value="L01FX26"/>
<display value="Mirvetuximab soravtansin"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectivePeriod>
<start value="2023-08-07"/>
<end value="2023-08-07"/>
</effectivePeriod>
<note>
<text
value="07.08.2023 Z3 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"/>
</note>
<dosage>
<timing>
<event value="2023-08-07"/>
</timing>
<doseAndRate>
<doseQuantity>
<value value="6"/>
<unit value="mg/kg KG"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg/kg{KG}"/>
</doseQuantity>
</doseAndRate>
</dosage>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url
value="MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-3"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-4"/>
<resource>
<MedicationStatement>
<id value="MII-EXA-MTB-Systemische-Therapie-Medication-4"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemtherapie-medication-statement"/>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-therapie-medication-statement|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<basedOn>🔗
<reference
value="MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"/>
</basedOn>
<partOf>🔗
<reference value="Procedure/MII-EXA-MTB-Systemische-Therapie-1"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<coding>
<system value="http://fdasis.nlm.nih.gov"/>
<code value="98DE7VN88D"/>
<display value="MIRVETUXIMAB SORAVTANSINE"/>
</coding>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<version value="2025"/>
<code value="L01FX26"/>
<display value="Mirvetuximab soravtansin"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectivePeriod>
<start value="2023-08-29"/>
<end value="2023-08-29"/>
</effectivePeriod>
<note>
<text
value="29.08.2023 Z4 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"/>
</note>
<dosage>
<timing>
<event value="2023-08-29"/>
</timing>
<doseAndRate>
<doseQuantity>
<value value="6"/>
<unit value="mg/kg KG"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg/kg{KG}"/>
</doseQuantity>
</doseAndRate>
</dosage>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url
value="MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-4"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-5"/>
<resource>
<MedicationStatement>
<id value="MII-EXA-MTB-Systemische-Therapie-Medication-5"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemtherapie-medication-statement"/>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-therapie-medication-statement|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<basedOn>🔗
<reference
value="MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"/>
</basedOn>
<partOf>🔗
<reference value="Procedure/MII-EXA-MTB-Systemische-Therapie-1"/>
</partOf>
<status value="completed"/>
<statusReason>
<coding>
<code value="E"/>
</coding>
</statusReason>
<medicationCodeableConcept>
<coding>
<system value="http://fdasis.nlm.nih.gov"/>
<code value="98DE7VN88D"/>
<display value="MIRVETUXIMAB SORAVTANSINE"/>
</coding>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<version value="2025"/>
<code value="L01FX26"/>
<display value="Mirvetuximab soravtansin"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectivePeriod>
<start value="2023-09-20"/>
<end value="2023-09-20"/>
</effectivePeriod>
<note>
<text
value="20.09.2023 Z2 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"/>
</note>
<dosage>
<timing>
<event value="2023-09-20"/>
</timing>
<doseAndRate>
<doseQuantity>
<value value="6"/>
<unit value="mg/kg KG"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg/kg{KG}"/>
</doseQuantity>
</doseAndRate>
</dosage>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url
value="MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-5"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-6"/>
<resource>
<MedicationStatement>
<id value="MII-EXA-MTB-Systemische-Therapie-Medication-6"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemtherapie-medication-statement"/>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-therapie-medication-statement|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<basedOn>🔗
<reference
value="MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"/>
</basedOn>
<partOf>🔗
<reference value="Procedure/MII-EXA-MTB-Systemische-Therapie-1"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<coding>
<system value="http://fdasis.nlm.nih.gov"/>
<code value="98DE7VN88D"/>
<display value="MIRVETUXIMAB SORAVTANSINE"/>
</coding>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<version value="2025"/>
<code value="L01FX26"/>
<display value="Mirvetuximab soravtansin"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectivePeriod>
<start value="2023-10-12"/>
<end value="2023-10-12"/>
</effectivePeriod>
<note>
<text
value="12.10.2023 Z3 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"/>
</note>
<dosage>
<timing>
<event value="2023-10-12"/>
</timing>
<doseAndRate>
<doseQuantity>
<value value="6"/>
<unit value="mg/kg KG"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg/kg{KG}"/>
</doseQuantity>
</doseAndRate>
</dosage>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url
value="MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-6"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/MII-EXA-MTB-Response-Befund-1"/>
<resource>
<Observation>
<id value="MII-EXA-MTB-Response-Befund-1"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-response-befund|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/MII-EXA-MTB-Systemische-Therapie-1"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="396432002"/>
<display
value="Status of regression of tumor (observable entity)"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<focus>🔗
<reference
value="Condition/PatientKimMusterperson-PrimaryDiagnosis-2"/>
</focus>
<effectiveDateTime value="2023-08-20"/>
<valueCodeableConcept>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-response-befund-beurteilung"/>
<code value="CR"/>
<display value="Complete Response"/>
</coding>
</valueCodeableConcept>
<method>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-response-befund-beurteilungsmethode"/>
<code value="RECIST"/>
<display value="RECIST"/>
</coding>
</method>
<component>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="399656008"/>
<display
value="Presence of metastatic neoplasm in regional lymph node (observable entity)"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-verlauf-lymphknoten"/>
<code value="K"/>
<display value="kein Lymphknotenbefall nachweisbar"/>
</coding>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/MII-EXA-MTB-Response-Befund-1"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/MII-EXA-MTB-Response-Befund-2"/>
<resource>
<Observation>
<id value="MII-EXA-MTB-Response-Befund-2"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-response-befund|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/MII-EXA-MTB-Systemische-Therapie-1"/>
</partOf>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="396432002"/>
<display
value="Status of regression of tumor (observable entity)"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<focus>🔗
<reference
value="Condition/PatientKimMusterperson-PrimaryDiagnosis-2"/>
</focus>
<effectiveDateTime value="2023-10-22"/>
<valueCodeableConcept>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-response-befund-beurteilung"/>
<code value="PR"/>
<display value="Partial Response"/>
</coding>
</valueCodeableConcept>
<method>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-response-befund-beurteilungsmethode"/>
<code value="RECIST"/>
<display value="RECIST"/>
</coding>
</method>
<component>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="399656008"/>
<display
value="Presence of metastatic neoplasm in regional lymph node (observable entity)"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-verlauf-lymphknoten"/>
<code value="K"/>
<display value="kein Lymphknotenbefall nachweisbar"/>
</coding>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/MII-EXA-MTB-Response-Befund-2"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Claim/MII-EXA-MTB-Antrag-Kostenuebernahme-1"/>
<resource>
<Claim>
<id value="MII-EXA-MTB-Antrag-Kostenuebernahme-1"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-antrag-kostenuebernahme|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="active"/>
<type>
<coding>
<code value="institutional"/>
</coding>
</type>
<use value="claim"/>
<patient>🔗
<reference value="Patient/PatientKimMusterperson"/>
</patient>
<created value="2023-03-10"/>
<provider>🔗
<reference value="Organization/MyHospital"/>
</provider>
<priority>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/processpriority"/>
<code value="normal"/>
</coding>
</priority>
<related>
<relationship>
<coding>
<code value="initial-claim"/>
</coding>
</relationship>
</related>
<prescription>🔗
<reference
value="MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"/>
</prescription>
<careTeam>
<sequence value="1"/>
<provider>🔗
<reference value="Organization/MyInsurer"/>
</provider>
<responsible value="true"/>
</careTeam>
<insurance>
<sequence value="1"/>
<focal value="true"/>
<coverage>🔗
<reference value="Coverage/MyCoverage"/>
</coverage>
<claimResponse>🔗
<reference
value="ClaimResponse/MII-EXA-MTB-Antwort-Kostenuebernahme-1"/>
</claimResponse>
</insurance>
</Claim>
</resource>
<request>
<method value="PUT"/>
<url value="Claim/MII-EXA-MTB-Antrag-Kostenuebernahme-1"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/ClaimResponse/MII-EXA-MTB-Antwort-Kostenuebernahme-1"/>
<resource>
<ClaimResponse>
<id value="MII-EXA-MTB-Antwort-Kostenuebernahme-1"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-antwort-kostenuebernahme|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="active"/>
<type>
<coding>
<code value="institutional"/>
</coding>
</type>
<use value="claim"/>
<patient>🔗
<reference value="Patient/PatientKimMusterperson"/>
</patient>
<created value="2023-05-01"/>
<insurer>🔗
<reference value="Organization/MyHospital"/>
</insurer>
<request>🔗
<reference value="Claim/MII-EXA-MTB-Antrag-Kostenuebernahme-1"/>
</request>
<outcome value="complete"/>
</ClaimResponse>
</resource>
<request>
<method value="PUT"/>
<url value="ClaimResponse/MII-EXA-MTB-Antwort-Kostenuebernahme-1"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Specimen/PatientKimMusterperson-Specimen-1"/>
<resource>
<Specimen>
<id value="PatientKimMusterperson-Specimen-1"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<identifier>
<value value="Z 230201/23"/>
</identifier>
<accessionIdentifier>
<value value="Z 230201/23"/>
</accessionIdentifier>
<status value="available"/>
<type>
<coding>
<system value="http://snomed.info/sct"/>
<code value="309201001"/>
<display value="Ascitic fluid specimen"/>
</coding>
</type>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<collection>
<collectedDateTime value="2023-01-02"/>
<quantity>
<value value="20"/>
<unit value="mL"/>
<system value="http://unitsofmeasure.org"/>
<code value="mL"/>
</quantity>
<method>
<coding>
<system value="http://snomed.info/sct"/>
<code value="178012008"/>
</coding>
</method>
</collection>
</Specimen>
</resource>
<request>
<method value="PUT"/>
<url value="Specimen/PatientKimMusterperson-Specimen-1"/>
</request>
</entry>
<entry>
<fullUrl value="http://example.org/fhir/Procedure/MTBChemo1Procedure"/>
<resource>
<Procedure>
<id value="MTBChemo1Procedure"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-vortherapie|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="extensions"/>
</text>
<extension
url="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-ex-onko-systemische-therapie-intention">
<valueCodeableConcept>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-intention"/>
<code value="K"/>
</coding>
</valueCodeableConcept>
</extension>
<status value="completed"/>
<category>
<coding>
<system value="http://snomed.info/sct"/>
<code value="277132007"/>
</coding>
</category>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="367336001"/>
</coding>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-therapie-typ"/>
<code value="CH"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<performedPeriod>
<start value="2023-01-04"/>
<end value="2023-05-24"/>
</performedPeriod>
<outcome>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-therapie-ende-grund"/>
<code value="W"/>
</coding>
<text value="Reguläres Ende mit Substanzwechsel"/>
</outcome>
</Procedure>
</resource>
<request>
<method value="PUT"/>
<url value="Procedure/MTBChemo1Procedure"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement1"/>
<resource>
<MedicationStatement>
<id value="MTBChemo1MedicationStatement1"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/MTBChemo1Procedure"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<text
value="Z1 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2, d1"/>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2023-01-04"/>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url value="MedicationStatement/MTBChemo1MedicationStatement1"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement1-1"/>
<resource>
<MedicationStatement>
<id value="MTBChemo1MedicationStatement1-1"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/MTBChemo1Procedure"/>
</partOf>
<partOf>🔗
<reference
value="MedicationStatement/MTBChemo1MedicationStatement1"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<code value="L01XA02"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2023-01-04"/>
<note>
<text
value="Z1 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"/>
</note>
<dosage>
<timing>
<event value="2023-01-04"/>
</timing>
<doseAndRate>
<doseQuantity>
<value value="5"/>
<unit value="AUC"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg.min/ml"/>
</doseQuantity>
</doseAndRate>
</dosage>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url value="MedicationStatement/MTBChemo1MedicationStatement1-1"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement1-2"/>
<resource>
<MedicationStatement>
<id value="MTBChemo1MedicationStatement1-2"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/MTBChemo1Procedure"/>
</partOf>
<partOf>🔗
<reference
value="MedicationStatement/MTBChemo1MedicationStatement1"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<code value="L01DB01"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2023-01-04"/>
<note>
<text
value="Z1 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"/>
</note>
<dosage>
<timing>
<event value="2023-01-04"/>
</timing>
<doseAndRate>
<doseQuantity>
<value value="30"/>
<unit value="mg/m2"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg/m2"/>
</doseQuantity>
</doseAndRate>
</dosage>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url value="MedicationStatement/MTBChemo1MedicationStatement1-2"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement2"/>
<resource>
<MedicationStatement>
<id value="MTBChemo1MedicationStatement2"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/MTBChemo1Procedure"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<text
value="Z2 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2, d1"/>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2023-02-01"/>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url value="MedicationStatement/MTBChemo1MedicationStatement2"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement2-1"/>
<resource>
<MedicationStatement>
<id value="MTBChemo1MedicationStatement2-1"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/MTBChemo1Procedure"/>
</partOf>
<partOf>🔗
<reference
value="MedicationStatement/MTBChemo1MedicationStatement2"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<code value="L01XA02"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2023-02-01"/>
<note>
<text
value="Z2 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"/>
</note>
<dosage>
<timing>
<event value="2023-02-01"/>
</timing>
<doseAndRate>
<doseQuantity>
<value value="5"/>
<unit value="AUC"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg.min/ml"/>
</doseQuantity>
</doseAndRate>
</dosage>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url value="MedicationStatement/MTBChemo1MedicationStatement2-1"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement2-2"/>
<resource>
<MedicationStatement>
<id value="MTBChemo1MedicationStatement2-2"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/MTBChemo1Procedure"/>
</partOf>
<partOf>🔗
<reference
value="MedicationStatement/MTBChemo1MedicationStatement2"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<code value="L01DB01"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2023-02-01"/>
<note>
<text
value="Z2 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"/>
</note>
<dosage>
<timing>
<event value="2023-02-01"/>
</timing>
<doseAndRate>
<doseQuantity>
<value value="30"/>
<unit value="mg/m2"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg/m2"/>
</doseQuantity>
</doseAndRate>
</dosage>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url value="MedicationStatement/MTBChemo1MedicationStatement2-2"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement3"/>
<resource>
<MedicationStatement>
<id value="MTBChemo1MedicationStatement3"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/MTBChemo1Procedure"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<text
value="Z3 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2, d1"/>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2023-03-01"/>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url value="MedicationStatement/MTBChemo1MedicationStatement3"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement3-1"/>
<resource>
<MedicationStatement>
<id value="MTBChemo1MedicationStatement3-1"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/MTBChemo1Procedure"/>
</partOf>
<partOf>🔗
<reference
value="MedicationStatement/MTBChemo1MedicationStatement3"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<code value="L01XA02"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2023-03-01"/>
<note>
<text
value="Z3 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"/>
</note>
<dosage>
<timing>
<event value="2023-03-01"/>
</timing>
<doseAndRate>
<doseQuantity>
<value value="5"/>
<unit value="AUC"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg.min/ml"/>
</doseQuantity>
</doseAndRate>
</dosage>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url value="MedicationStatement/MTBChemo1MedicationStatement3-1"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement3-2"/>
<resource>
<MedicationStatement>
<id value="MTBChemo1MedicationStatement3-2"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/MTBChemo1Procedure"/>
</partOf>
<partOf>🔗
<reference
value="MedicationStatement/MTBChemo1MedicationStatement3"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<code value="L01DB01"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2023-03-01"/>
<note>
<text
value="Z3 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"/>
</note>
<dosage>
<timing>
<event value="2023-03-01"/>
</timing>
<doseAndRate>
<doseQuantity>
<value value="30"/>
<unit value="mg/m2"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg/m2"/>
</doseQuantity>
</doseAndRate>
</dosage>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url value="MedicationStatement/MTBChemo1MedicationStatement3-2"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement4"/>
<resource>
<MedicationStatement>
<id value="MTBChemo1MedicationStatement4"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/MTBChemo1Procedure"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<text
value="Z4 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2, d1"/>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2023-03-29"/>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url value="MedicationStatement/MTBChemo1MedicationStatement4"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement4-1"/>
<resource>
<MedicationStatement>
<id value="MTBChemo1MedicationStatement4-1"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/MTBChemo1Procedure"/>
</partOf>
<partOf>🔗
<reference
value="MedicationStatement/MTBChemo1MedicationStatement4"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<code value="L01XA02"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2023-03-29"/>
<note>
<text
value="Z4 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"/>
</note>
<dosage>
<timing>
<event value="2023-03-29"/>
</timing>
<doseAndRate>
<doseQuantity>
<value value="5"/>
<unit value="AUC"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg.min/ml"/>
</doseQuantity>
</doseAndRate>
</dosage>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url value="MedicationStatement/MTBChemo1MedicationStatement4-1"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement4-2"/>
<resource>
<MedicationStatement>
<id value="MTBChemo1MedicationStatement4-2"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/MTBChemo1Procedure"/>
</partOf>
<partOf>🔗
<reference
value="MedicationStatement/MTBChemo1MedicationStatement4"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<code value="L01DB01"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2023-03-29"/>
<note>
<text
value="Z4 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"/>
</note>
<dosage>
<timing>
<event value="2023-03-29"/>
</timing>
<doseAndRate>
<doseQuantity>
<value value="30"/>
<unit value="mg/m2"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg/m2"/>
</doseQuantity>
</doseAndRate>
</dosage>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url value="MedicationStatement/MTBChemo1MedicationStatement4-2"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement5"/>
<resource>
<MedicationStatement>
<id value="MTBChemo1MedicationStatement5"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/MTBChemo1Procedure"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<text
value="Z5 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2, d1"/>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2023-04-26"/>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url value="MedicationStatement/MTBChemo1MedicationStatement5"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement5-1"/>
<resource>
<MedicationStatement>
<id value="MTBChemo1MedicationStatement5-1"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/MTBChemo1Procedure"/>
</partOf>
<partOf>🔗
<reference
value="MedicationStatement/MTBChemo1MedicationStatement5"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<code value="L01XA02"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2023-04-26"/>
<note>
<text
value="Z5 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"/>
</note>
<dosage>
<timing>
<event value="2023-04-26"/>
</timing>
<doseAndRate>
<doseQuantity>
<value value="5"/>
<unit value="AUC"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg.min/ml"/>
</doseQuantity>
</doseAndRate>
</dosage>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url value="MedicationStatement/MTBChemo1MedicationStatement5-1"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement5-2"/>
<resource>
<MedicationStatement>
<id value="MTBChemo1MedicationStatement5-2"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/MTBChemo1Procedure"/>
</partOf>
<partOf>🔗
<reference
value="MedicationStatement/MTBChemo1MedicationStatement5"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<code value="L01DB01"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2023-04-26"/>
<note>
<text
value="Z5 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"/>
</note>
<dosage>
<timing>
<event value="2023-04-26"/>
</timing>
<doseAndRate>
<doseQuantity>
<value value="30"/>
<unit value="mg/m2"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg/m2"/>
</doseQuantity>
</doseAndRate>
</dosage>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url value="MedicationStatement/MTBChemo1MedicationStatement5-2"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement6"/>
<resource>
<MedicationStatement>
<id value="MTBChemo1MedicationStatement6"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/MTBChemo1Procedure"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<text
value="Z6 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2, d1"/>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2023-05-24"/>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url value="MedicationStatement/MTBChemo1MedicationStatement6"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement6-1"/>
<resource>
<MedicationStatement>
<id value="MTBChemo1MedicationStatement6-1"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/MTBChemo1Procedure"/>
</partOf>
<partOf>🔗
<reference
value="MedicationStatement/MTBChemo1MedicationStatement6"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<code value="L01XA02"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2023-05-24"/>
<note>
<text
value="Z6 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"/>
</note>
<dosage>
<timing>
<event value="2023-05-24"/>
</timing>
<doseAndRate>
<doseQuantity>
<value value="5"/>
<unit value="AUC"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg.min/ml"/>
</doseQuantity>
</doseAndRate>
</dosage>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url value="MedicationStatement/MTBChemo1MedicationStatement6-1"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement6-2"/>
<resource>
<MedicationStatement>
<id value="MTBChemo1MedicationStatement6-2"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<partOf>🔗
<reference value="Procedure/MTBChemo1Procedure"/>
</partOf>
<partOf>🔗
<reference
value="MedicationStatement/MTBChemo1MedicationStatement6"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<code value="L01DB01"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2023-05-24"/>
<note>
<text
value="Z6 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"/>
</note>
<dosage>
<timing>
<event value="2023-05-24"/>
</timing>
<doseAndRate>
<doseQuantity>
<value value="30"/>
<unit value="mg/m2"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg/m2"/>
</doseQuantity>
</doseAndRate>
</dosage>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url value="MedicationStatement/MTBChemo1MedicationStatement6-2"/>
</request>
</entry>
<entry>
<fullUrl value="http://example.org/fhir/Procedure/MTBChemo2Procedure"/>
<resource>
<Procedure>
<id value="MTBChemo2Procedure"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-vortherapie|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="extensions"/>
</text>
<extension
url="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-ex-onko-systemische-therapie-intention">
<valueCodeableConcept>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-intention"/>
<code value="K"/>
</coding>
</valueCodeableConcept>
</extension>
<basedOn>🔗
<reference
value="CarePlan/mii-exa-mtb-kim-musterperson-therapieplan"/>
</basedOn>
<status value="completed"/>
<category>
<coding>
<system value="http://snomed.info/sct"/>
<code value="277132007"/>
</coding>
</category>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="367336001"/>
</coding>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-therapie-typ"/>
<code value="CH"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<performedPeriod>
<start value="2023-06-24"/>
<end value="2023-10-12"/>
</performedPeriod>
<outcome>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-therapie-ende-grund"/>
<code value="E"/>
</coding>
<text value="Reguläres Ende"/>
</outcome>
</Procedure>
</resource>
<request>
<method value="PUT"/>
<url value="Procedure/MTBChemo2Procedure"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MTBChemo2MedicationStatement1"/>
<resource>
<MedicationStatement>
<id value="MTBChemo2MedicationStatement1"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<basedOn>🔗
<reference
value="MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"/>
</basedOn>
<partOf>🔗
<reference value="Procedure/MTBChemo2Procedure"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<coding>
<system value="http://fdasis.nlm.nih.gov"/>
<code value="98DE7VN88D"/>
<display value="MIRVETUXIMAB SORAVTANSINE"/>
</coding>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<version value="2025"/>
<code value="L01FX26"/>
<display value="Mirvetuximab soravtansin"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2023-06-24"/>
<note>
<text value="Z1 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"/>
</note>
<dosage>
<timing>
<event value="2023-06-24"/>
</timing>
<doseAndRate>
<doseQuantity>
<value value="6"/>
<unit value="mg/kg KG"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg/kg{KG}"/>
</doseQuantity>
</doseAndRate>
</dosage>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url value="MedicationStatement/MTBChemo2MedicationStatement1"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MTBChemo2MedicationStatement2"/>
<resource>
<MedicationStatement>
<id value="MTBChemo2MedicationStatement2"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<basedOn>🔗
<reference
value="MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"/>
</basedOn>
<partOf>🔗
<reference value="Procedure/MTBChemo2Procedure"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<coding>
<system value="http://fdasis.nlm.nih.gov"/>
<code value="98DE7VN88D"/>
<display value="MIRVETUXIMAB SORAVTANSINE"/>
</coding>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<version value="2025"/>
<code value="L01FX26"/>
<display value="Mirvetuximab soravtansin"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2023-07-16"/>
<note>
<text value="Z2 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"/>
</note>
<dosage>
<timing>
<event value="2023-07-16"/>
</timing>
<doseAndRate>
<doseQuantity>
<value value="6"/>
<unit value="mg/kg KG"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg/kg{KG}"/>
</doseQuantity>
</doseAndRate>
</dosage>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url value="MedicationStatement/MTBChemo2MedicationStatement2"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MTBChemo2MedicationStatement3"/>
<resource>
<MedicationStatement>
<id value="MTBChemo2MedicationStatement3"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<basedOn>🔗
<reference
value="MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"/>
</basedOn>
<partOf>🔗
<reference value="Procedure/MTBChemo2Procedure"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<coding>
<system value="http://fdasis.nlm.nih.gov"/>
<code value="98DE7VN88D"/>
<display value="MIRVETUXIMAB SORAVTANSINE"/>
</coding>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<version value="2025"/>
<code value="L01FX26"/>
<display value="Mirvetuximab soravtansin"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2023-08-07"/>
<note>
<text value="Z3 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"/>
</note>
<dosage>
<timing>
<event value="2023-08-07"/>
</timing>
<doseAndRate>
<doseQuantity>
<value value="6"/>
<unit value="mg/kg KG"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg/kg{KG}"/>
</doseQuantity>
</doseAndRate>
</dosage>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url value="MedicationStatement/MTBChemo2MedicationStatement3"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MTBChemo2MedicationStatement4"/>
<resource>
<MedicationStatement>
<id value="MTBChemo2MedicationStatement4"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<basedOn>🔗
<reference
value="MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"/>
</basedOn>
<partOf>🔗
<reference value="Procedure/MTBChemo2Procedure"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<coding>
<system value="http://fdasis.nlm.nih.gov"/>
<code value="98DE7VN88D"/>
<display value="MIRVETUXIMAB SORAVTANSINE"/>
</coding>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<version value="2025"/>
<code value="L01FX26"/>
<display value="Mirvetuximab soravtansin"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2023-08-29"/>
<note>
<text value="Z4 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"/>
</note>
<dosage>
<timing>
<event value="2023-08-29"/>
</timing>
<doseAndRate>
<doseQuantity>
<value value="6"/>
<unit value="mg/kg KG"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg/kg{KG}"/>
</doseQuantity>
</doseAndRate>
</dosage>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url value="MedicationStatement/MTBChemo2MedicationStatement4"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MTBChemo2MedicationStatement5"/>
<resource>
<MedicationStatement>
<id value="MTBChemo2MedicationStatement5"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<basedOn>🔗
<reference
value="MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"/>
</basedOn>
<partOf>🔗
<reference value="Procedure/MTBChemo2Procedure"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<coding>
<system value="http://fdasis.nlm.nih.gov"/>
<code value="98DE7VN88D"/>
<display value="MIRVETUXIMAB SORAVTANSINE"/>
</coding>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<version value="2025"/>
<code value="L01FX26"/>
<display value="Mirvetuximab soravtansin"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2023-09-20"/>
<note>
<text value="Z5 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"/>
</note>
<dosage>
<timing>
<event value="2023-09-20"/>
</timing>
<doseAndRate>
<doseQuantity>
<value value="6"/>
<unit value="mg/kg KG"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg/kg{KG}"/>
</doseQuantity>
</doseAndRate>
</dosage>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url value="MedicationStatement/MTBChemo2MedicationStatement5"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationStatement/MTBChemo2MedicationStatement6"/>
<resource>
<MedicationStatement>
<id value="MTBChemo2MedicationStatement6"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<basedOn>🔗
<reference
value="MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"/>
</basedOn>
<partOf>🔗
<reference value="Procedure/MTBChemo2Procedure"/>
</partOf>
<status value="completed"/>
<medicationCodeableConcept>
<coding>
<system value="http://fdasis.nlm.nih.gov"/>
<code value="98DE7VN88D"/>
<display value="MIRVETUXIMAB SORAVTANSINE"/>
</coding>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<version value="2025"/>
<code value="L01FX26"/>
<display value="Mirvetuximab soravtansin"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2023-10-12"/>
<note>
<text value="Z6 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"/>
</note>
<dosage>
<timing>
<event value="2023-10-12"/>
</timing>
<doseAndRate>
<doseQuantity>
<value value="6"/>
<unit value="mg/kg KG"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg/kg{KG}"/>
</doseQuantity>
</doseAndRate>
</dosage>
</MedicationStatement>
</resource>
<request>
<method value="PUT"/>
<url value="MedicationStatement/MTBChemo2MedicationStatement6"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/DiagnosticReport/mii-exa-mtb-kim-musterperson-ngs-bericht"/>
<resource>
<DiagnosticReport>
<id value="mii-exa-mtb-kim-musterperson-ngs-bericht"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-ngs-bericht|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="final"/>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
<display value="Genetics"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="51969-4"/>
<display value="Genetic analysis report"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<issued value="2023-03-28T00:00:00.000Z"/>
<specimen>🔗
<reference
value="Specimen/PatientKimMusterperson-AscitesSpecimen-2"/>
</specimen>
<result>🔗
<reference
value="Observation/mii-exa-mtb-kim-musterperson-EinfacheVariante-TP53"/>
</result>
<result>🔗
<reference
value="Observation/mii-exa-mtb-kim-musterperson-EinfacheVariante-PIK3R1"/>
</result>
<result>🔗
<reference
value="Observation/mii-exa-mtb-kim-musterperson-CNVariante-CCNE1"/>
</result>
</DiagnosticReport>
</resource>
<request>
<method value="PUT"/>
<url value="DiagnosticReport/mii-exa-mtb-kim-musterperson-ngs-bericht"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Procedure/mii-exa-mtb-kim-musterperson-genomic-study"/>
<resource>
<Procedure>
<id value="mii-exa-mtb-kim-musterperson-genomic-study"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-genomic-study|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="extensions"/>
</text>
<extension
url="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-ext">
<valueReference>🔗
<reference
value="Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-1"/>
</valueReference>
</extension>
<extension
url="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-ext">
<valueReference>🔗
<reference
value="Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-2"/>
</valueReference>
</extension>
<extension
url="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-ext">
<valueReference>🔗
<reference
value="Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-3"/>
</valueReference>
</extension>
<status value="completed"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
</Procedure>
</resource>
<request>
<method value="PUT"/>
<url value="Procedure/mii-exa-mtb-kim-musterperson-genomic-study"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-1"/>
<resource>
<Procedure>
<id value="mii-exa-mtb-kim-musterperson-genomic-study-analysis-1"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-genomic-study-analysis|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="extensions"/>
</text>
<extension
url="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-method-type">
<valueCodeableConcept>
<coding>
<system
value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/genomic-study-method-type-cs"/>
<code value="ngs-mps"/>
<display
value="Next-Generation (NGS)/Massively parallel sequencing (MPS)"/>
</coding>
</valueCodeableConcept>
</extension>
<extension
url="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-change-type">
<valueCodeableConcept>
<coding>
<system value="http://www.sequenceontology.org"/>
<code value="SO:0001483"/>
<display value="SNV"/>
</coding>
</valueCodeableConcept>
</extension>
<extension
url="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-genome-build">
<valueCodeableConcept>
<coding>
<system value="http://loinc.org"/>
<code value="LA26806-2"/>
<display value="GRCh38"/>
</coding>
</valueCodeableConcept>
</extension>
<status value="completed"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
</Procedure>
</resource>
<request>
<method value="PUT"/>
<url
value="Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-1"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-2"/>
<resource>
<Procedure>
<id value="mii-exa-mtb-kim-musterperson-genomic-study-analysis-2"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-genomic-study-analysis|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="completed"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
</Procedure>
</resource>
<request>
<method value="PUT"/>
<url
value="Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-2"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-3"/>
<resource>
<Procedure>
<id value="mii-exa-mtb-kim-musterperson-genomic-study-analysis-3"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-genomic-study-analysis|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="extensions"/>
</text>
<extension
url="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-method-type">
<valueCodeableConcept>
<coding>
<system
value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/genomic-study-method-type-cs"/>
<code value="immunohistochemistry"/>
<display value="Immunohistochemistry"/>
</coding>
</valueCodeableConcept>
</extension>
<status value="completed"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
</Procedure>
</resource>
<request>
<method value="PUT"/>
<url
value="Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-3"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/mii-exa-mtb-kim-musterperson-EinfacheVariante-TP53"/>
<resource>
<Observation>
<id value="mii-exa-mtb-kim-musterperson-EinfacheVariante-TP53"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-einfache-variante|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
<display value="Laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="69548-6"/>
<display value="Genetic variant assessment"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<valueCodeableConcept>
<coding>
<system value="http://loinc.org"/>
<code value="LA9633-4"/>
<display value="Present"/>
</coding>
</valueCodeableConcept>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
<display value="Gene studied [ID]"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org/geneId"/>
<code value="HGNC:11998"/>
<display value="TP53"/>
</coding>
</valueCodeableConcept>
</component>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48005-3"/>
<display value="Amino acid change (pHGVS)"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://varnomen.hgvs.org"/>
<code value="NP_000537.3:p.Arg213Ter"/>
</coding>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url
value="Observation/mii-exa-mtb-kim-musterperson-EinfacheVariante-TP53"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/mii-exa-mtb-kim-musterperson-DiagnostischeImplikation-TP53"/>
<resource>
<Observation>
<id
value="mii-exa-mtb-kim-musterperson-DiagnostischeImplikation-TP53"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-diagnostische-implikation|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
<display value="Laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
<code value="diagnostic-implication"/>
<display value="Diagnostic Implication"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<derivedFrom>🔗
<reference
value="Observation/mii-exa-mtb-kim-musterperson-EinfacheVariante-TP53"/>
</derivedFrom>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="53037-8"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://loinc.org"/>
<code value="LA6668-3"/>
<display value="Pathogenic"/>
</coding>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url
value="Observation/mii-exa-mtb-kim-musterperson-DiagnostischeImplikation-TP53"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/mii-exa-mtb-kim-musterperson-EinfacheVariante-PIK3R1"/>
<resource>
<Observation>
<id value="mii-exa-mtb-kim-musterperson-EinfacheVariante-PIK3R1"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-einfache-variante|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
<display value="Laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="69548-6"/>
<display value="Genetic variant assessment"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<valueCodeableConcept>
<coding>
<system value="http://loinc.org"/>
<code value="LA9633-4"/>
<display value="Present"/>
</coding>
</valueCodeableConcept>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
<display value="Gene studied [ID]"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org/geneId"/>
<code value="HGNC:8979"/>
<display value="PIK3R1"/>
</coding>
</valueCodeableConcept>
</component>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48005-3"/>
<display value="Amino acid change (pHGVS)"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://varnomen.hgvs.org"/>
<code value="NP_852664.1:p.(Glu160Ter)"/>
</coding>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url
value="Observation/mii-exa-mtb-kim-musterperson-EinfacheVariante-PIK3R1"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/mii-exa-mtb-kim-musterperson-TherapeutischeImplikation-PIK3R1"/>
<resource>
<Observation>
<id
value="mii-exa-mtb-kim-musterperson-TherapeutischeImplikation-PIK3R1"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapeutische-implikation|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="extensions"/>
</text>
<extension
url="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-evidenzgraduierung">
<valueCodeableConcept>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-empfehlung-evidenzgrad"/>
<code value="m3"/>
</coding>
</valueCodeableConcept>
</extension>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
<display value="Laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
<code value="therapeutic-implication"/>
<display value="Therapeutic Implication"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<derivedFrom>🔗
<reference
value="Observation/mii-exa-mtb-kim-musterperson-EinfacheVariante-PIK3R1"/>
</derivedFrom>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
<code value="conclusion-string"/>
</coding>
</code>
<valueString
value="Ausweislich praeklinischer Daten liegt ein Ansprechen auf MEK-Inhibition nahe (PMID: 31209687, EL m3)."/>
</component>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="51963-7"/>
<display value="Medication assessed [ID]"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<code value="L01EE"/>
<display
value="Mitogen-aktivierte Proteinkinase (MEK)-Inhibitoren"/>
</coding>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url
value="Observation/mii-exa-mtb-kim-musterperson-TherapeutischeImplikation-PIK3R1"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/mii-exa-mtb-kim-musterperson-CNVariante-CCNE1"/>
<resource>
<Observation>
<id value="mii-exa-mtb-kim-musterperson-CNVariante-CCNE1"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-copy-number-variant|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
<display value="Laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="69548-6"/>
<display value="Genetic variant assessment"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<valueCodeableConcept>
<coding>
<system value="http://loinc.org"/>
<code value="LA9633-4"/>
<display value="Present"/>
</coding>
</valueCodeableConcept>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
<display value="Gene studied [ID]"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org/geneId"/>
<code value="HGNC:1589"/>
<display value="CCNE1"/>
</coding>
</valueCodeableConcept>
</component>
<component>
<code>
<coding>
<system
value="http://bwhc.de/mtb/genetics-copy-number-variant"/>
<code value="type"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system
value="http://bwhc.de/mtb/genetics-copy-number-variant"/>
<code value="high-level-gain"/>
<display value="high-level-gain"/>
</coding>
</valueCodeableConcept>
</component>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="82155-3"/>
<display value="Genomic structural variant copy number"/>
</coding>
</code>
<valueQuantity>
<value value="7"/>
<system value="http://unitsofmeasure.org"/>
<code value="1"/>
</valueQuantity>
</component>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/mii-exa-mtb-kim-musterperson-CNVariante-CCNE1"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/ServiceRequest/mii-exa-mtb-study-request-cldn6"/>
<resource>
<ServiceRequest>
<id value="mii-exa-mtb-study-request-cldn6"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-studieneinschluss-anfrage|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="extensions"/>
</text>
<extension
url="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-prioritaet">
<valueDecimal value="2.1"/>
</extension>
<extension
url="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-publikation">
<valueIdentifier>
<system value="http://www.ncbi.nlm.nih.gov/pubmed"/>
<value value="37872225"/>
</valueIdentifier>
</extension>
<status value="draft"/>
<intent value="proposal"/>
<category>
<coding>
<system value="http://snomed.info/sct"/>
<code value="110465008"/>
<display value="Clinical trial (procedure)"/>
</coding>
</category>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="702475000"/>
<display value="Referral to clinical trial (procedure)"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<supportingInfo>🔗
<reference value="ResearchStudy/mii-exa-mtb-study-cldn6"/>
</supportingInfo>
</ServiceRequest>
</resource>
<request>
<method value="PUT"/>
<url value="ServiceRequest/mii-exa-mtb-study-request-cldn6"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/ResearchStudy/mii-exa-mtb-study-cldn6"/>
<resource>
<ResearchStudy>
<id value="mii-exa-mtb-study-cldn6"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-studie|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<identifier>
<system
value="https://www.medizininformatik-initiative.de/fhir/modul-mtb/sid/nct"/>
<value value="04503278"/>
</identifier>
<status value="active"/>
<primaryPurposeType>
<coding>
<code value="treatment"/>
</coding>
</primaryPurposeType>
<phase>
<coding>
<code value="phase-1"/>
</coding>
</phase>
<condition>
<coding>
<system value="http://snomed.info/sct"/>
<code value="369757002"/>
<display value="Solid tumor configuration"/>
</coding>
</condition>
<keyword>
<text value="Non-small cell lung cancer (NSCLC)"/>
</keyword>
<enrollment>🔗
<reference
value="Group/mii-exa-mtb-study-cldn6-eligibility-criteria"/>
</enrollment>
<period>
<start value="2020-09-16"/>
<end value="2040-01"/>
</period>
<sponsor>🔗
<reference value="Organization/mii-exa-mtb-study-sponsor-biontech"/>
</sponsor>
<principalInvestigator>🔗
<reference
value="PractitionerRole/mii-exa-mtb-study-investigator-biontech"/>
</principalInvestigator>
<site>🔗
<reference value="Location/mii-exa-mtb-study-cldn6-location-11"/>
</site>
<arm>
<name
value="Part 1 - CLDN6 CAR-T: Dose escalation in lymphodepleted patients until the MTD and/or RP2D"/>
</arm>
<arm>
<name
value="Part 2 Vaccine-modulated - CLDN6 uRNA-LPX/CLDN6 modRNA-LPX: Dose escalation until the MTD and/or RP2D"/>
</arm>
<objective>
<name
value="Occurrence of treatment-emergent adverse events (TEAEs) including ≥ Grade 3, serious, fatal TEAEs by relationship"/>
<type>
<coding>
<code value="primary"/>
</coding>
</type>
</objective>
<objective>
<name
value="Occurrence of dose reduction and discontinuation of investigational medicinal product (IMP) due to TEAEs"/>
<type>
<coding>
<code value="primary"/>
</coding>
</type>
</objective>
<objective>
<name
value="Occurrence of dose-limiting toxicity (DLT) during the DLT evaluation period"/>
<type>
<coding>
<code value="primary"/>
</coding>
</type>
</objective>
<objective>
<name
value="Change from baseline in the levels and kinetics of soluble immune factors measured by cytokine multiplex assay"/>
<type>
<coding>
<code value="secondary"/>
</coding>
</type>
</objective>
<objective>
<name
value="Objective response rate (ORR) defined as the proportion of patients in whom a complete response (CR) or partial response (PR) (per response evaluation criteria in solid tumors [RECIST 1.1]) is observed as best overall response"/>
<type>
<coding>
<code value="secondary"/>
</coding>
</type>
</objective>
<objective>
<name
value="Disease control rate (DCR) defined as the proportion of patients in whom a CR or PR or stable disease (SD) (per RECIST 1.1, SD assessed at least 6 weeks after the first dose) is observed as best overall response"/>
<type>
<coding>
<code value="secondary"/>
</coding>
</type>
</objective>
<objective>
<name
value="Duration of response (DOR) defined as the time from first objective response (CR or PR per RECIST 1.1) to first occurrence of objective progressive disease (PD) per RECIST 1.1/recurrence or death from any cause, whichever occurs first"/>
<type>
<coding>
<code value="secondary"/>
</coding>
</type>
</objective>
</ResearchStudy>
</resource>
<request>
<method value="PUT"/>
<url value="ResearchStudy/mii-exa-mtb-study-cldn6"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Group/mii-exa-mtb-study-cldn6-eligibility-criteria"/>
<resource>
<Group>
<id value="mii-exa-mtb-study-cldn6-eligibility-criteria"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<type value="person"/>
<actual value="false"/>
<quantity value="145"/>
<characteristic>
<code>
<text value="Eligibility Criteria"/>
</code>
<valueReference>
<display
value="Inclusion Criteria:
* Each patient enrolled in the trial must have CLDN6-positive tumor regardless of tumor histology defined as ≥ 50% of tumor cells expressing ≥ 2+ CLDN6 protein using a semi-quantitative immunohistochemistry (IHC) assay in a central laboratory for specific detection of CLDN6 protein expression in formalin-fixed, paraffin-embedded (FFPE) neoplastic tissues.
* Availability of a FFPE tumor tissue sample. FFPE can be from an archival tumor tissue sample, and it should be from the most recent tumor tissue obtained. If this is not available, patient must be biopsied for CLDN6 staining.
* Must have histological documentation of the original primary tumor via a pathology report.
* Must have measurable disease per RECIST 1.1 (except for germ cell tumors, where patients can be evaluated according to Cancer-Antigen (CA)-125, Alpha-fetoprotein or human chorionic gonadotropin \[as applicable\] or ovarian cancer, where patients can be evaluated according to CA-125. The pre-treatment sample must be at least twice the upper limit of normal).
* Must have a histologically confirmed solid tumor that is metastatic or unresectable and for which there is no available standard therapy likely to confer clinical benefit, or patient who is not a candidate for such available therapy.
* Must be ≥ 18 years of age at the time the pre-screening informed consent is signed.
* Must sign an informed consent form (ICF) indicating that he or she understands the purpose of and procedures required for the trial and are willing to participate in the trial prior to any trial-related assessments or procedures.
* Must have an Eastern Cooperative Oncology Group performance status of 0 to 1.
* Must have adequate coagulation function at screening as defined in the protocol.
* Must have adequate hematologic function at screening as defined in the protocol.
* Must have adequate hepatic function at screening as defined in the protocol.
* Must have adequate renal function at screening as defined in the protocol.
* Must be able to attend trial visits as required by the protocol.
* Women of childbearing potential (WOCBP) must have a negative serum (beta-human chorionic gonadotropin) test/value at screening. Patients who are post-menopausal or permanently sterilized can be considered as not having reproductive potential.
* WOCBP must agree not to donate eggs (ova, oocytes) for the purposes of assisted reproduction during the entire trial and thereafter.
* WOCBP and men that are sexually active with a WOCBP and have not had a vasectomy must agree to use highly effective birth control method(s), as defined in the protocol. True abstinence is an acceptable alternative to the use of contraception.
* Men must agree not to father a child or donate sperm, and WOCBP must agree not to become pregnant during the trial and for at least 12 months after the CLDN6 CAR-T infusion or CLDN6 RNA-LPX treatment.
For Part 2 only:
* Histologically or cytologically confirmed solid tumor fulfilling inclusion criteria 1-4 that is metastatic or unresectable, and for whom there is no available standard therapy likely to confer clinical benefit, or patient who is not a candidate for such available therapy.
Exclusion Criteria:
* Has received prior CAR-T therapy, except CLDN6 CAR-T therapy.
* Has received vaccination with live virus vaccines within 6 weeks prior to the start of lymphodepletion (LD).
* Receives concurrent systemic (oral or i.v.) steroid therapy \> 10 mg prednisolone daily, or its equivalent, for an underlying condition.
* Has side effects of any prior therapy or procedures for any medical condition not recovered to national cancer institute common terminology criteria for adverse events (CTCAE v.5) Grade ≤ 1.
Medical conditions:
* Current evidence of new or growing brain or spinal metastases during screening. Patients with known brain or spinal metastases may be eligible if they:
1. Have had radiotherapy or another appropriate therapy for the brain or spinal metastases,
2. Have no neurological symptoms,
3. Have stable brain or spinal disease on the computer tomography or magnetic resonance imaging scan within 4 weeks before signing of the ICF,
4. Are not undergoing acute corticosteroid therapy or steroid taper. Chronic steroid therapy is acceptable provided that the dose is stable for the last 14 days prior to screening (≤ 10 mg prednisolone daily or equivalent),
5. Do not require steroid therapy within 7 days before the first dose of CLDN6 CAR-T,
6. Do not have anticipated imminent fracture or cord compression due to spinal bone metastases.
* Has history of epilepsy. Isolated seizures in the past or febrile seizures in childhood are permitted; has a history of a cerebrovascular accident or transient ischemic attack less than 6 months ago.
* Pericardial effusion requiring any drainage is excluded.
* Has an active autoimmune disease including but not limited to inflammatory bowel disease, systemic lupus erythematosus, ankylosing spondylitis, scleroderma, or multiple sclerosis. Has any active immunologic disorder requiring immunosuppression with steroids or other immunosuppressive agents with the exception of patients with isolated vitiligo, resolved childhood asthma or atopic dermatitis, controlled hypoadrenalism or hypopituitarism, and euthyroid patients with a history of Grave's disease. Patients with controlled hyperthyroidism must be negative for thyroglobulin, thyroid peroxidase antibodies, and thyroid-stimulating immunoglobulin prior to trial drug administration.
* Seropositivity for human immunodeficiency virus.
* Known history/positive serology for hepatitis B requiring active antiviral therapy (unless immune due to vaccination or resolved natural infection or unless passive immunization due to immunoglobulin therapy). Patients with positive serology must have hepatitis B virus viral load below the limit of quantification.
* Active hepatitis C virus (HCV) infection; patients who have completed curative antiviral treatment with HCV viral load below the limit of quantification are allowed.
* Has a known hypersensitivity to a component of CLDN6 CAR-T or CLDN6 RNA-LPX cancer vaccine drug product, or another similar compound.
* Only for patients recruited for Part 2 with LD chemotherapy (CLDN6 CAR-T + CLDN6 RNA-LPX with LD chemotherapy): history of severe immediate hypersensitivity reaction to LD chemotherapy consisting of cyclophosphamide or fludarabine.
* Has a history of another primary cancer within the 2 years prior to enrollment except for the following: Non-melanoma skin cancer, cervical carcinoma in situ, superficial bladder cancer, prostate cancer with currently undetectable prostate specific antigen, or other non-metastatic carcinoma that has been in complete remission without treatment for more than 2 years.
* Receipt of allogenic stem cell transplantation in the 5 years prior to enrollment into the trial.
* Patients with acute or chronic graft versus host disease.
Other comorbidities:
* Has abnormal electrocardiograms that are clinically significant, such as QT prolongation.
* In the opinion of the Investigator, has any concurrent conditions that could pose an undue medical hazard or interfere with the interpretation of the trial results; these conditions include, but are not limited to:
1. Ongoing or active infection requiring antibiotic/antiviral/antifungal therapy
2. Concurrent congestive heart failure (New York Heart Association Functional Classification Class III or IV)
3. Concurrent unstable angina
4. Concurrent cardiac arrhythmia requiring treatment (excluding asymptomatic atrial fibrillation)
5. Acute coronary syndrome within the previous 6 months
6. Significant pulmonary disease (shortness of breath at rest or on mild exertion) for example due concurrent severe obstructive pulmonary disease.
* Has a cognitive, psychological or psychosocial impediment that would impair the ability of the patient to receive therapy according to the protocol or adversely affect the ability of the patient to comply with the informed consent process, protocol, or protocol-required visits and procedures.
* Is pregnant or breastfeeding"/>
</valueReference>
<exclude value="false"/>
</characteristic>
<characteristic>
<code>
<text value="Accepts Healthy Volunteers"/>
</code>
<valueBoolean value="false"/>
<exclude value="false"/>
</characteristic>
<characteristic>
<code>
<text value="Age"/>
</code>
<valueRange>
<low>
<value value="18"/>
<unit value="year"/>
<system value="http://unitsofmeasure.org"/>
<code value="a"/>
</low>
</valueRange>
<exclude value="false"/>
</characteristic>
<characteristic>
<code>
<text value="Age Group"/>
</code>
<valueReference>🔗
<reference
value="Group/mii-exa-mtb-study-cldn6-eligibility-criteria-age-groups"/>
</valueReference>
<exclude value="false"/>
</characteristic>
</Group>
</resource>
<request>
<method value="PUT"/>
<url value="Group/mii-exa-mtb-study-cldn6-eligibility-criteria"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Group/mii-exa-mtb-study-cldn6-eligibility-criteria-age-groups"/>
<resource>
<Group>
<id value="mii-exa-mtb-study-cldn6-eligibility-criteria-age-groups"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<type value="person"/>
<actual value="false"/>
<characteristic>
<code>
<text value="Age Group (Adult)"/>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="41847000"/>
<display value="Adulthood (qualifier value)"/>
</coding>
</valueCodeableConcept>
<exclude value="false"/>
</characteristic>
<characteristic>
<code>
<text value="Age Group (Older Adult)"/>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="271872005"/>
<display value="Old age (qualifier value)"/>
</coding>
</valueCodeableConcept>
<exclude value="false"/>
</characteristic>
</Group>
</resource>
<request>
<method value="PUT"/>
<url
value="Group/mii-exa-mtb-study-cldn6-eligibility-criteria-age-groups"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Group/mii-exa-mtb-study-cldn6-comparison-group-0"/>
<resource>
<Group>
<id value="mii-exa-mtb-study-cldn6-comparison-group-0"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<type value="person"/>
<actual value="false"/>
<characteristic>
<code>
<text value="Exposed to"/>
</code>
<valueReference>🔗
<reference
value="EvidenceVariable/mii-exa-mtb-study-cldn6-evidence-variable-0"/>
<display value="Biological: CLDN6 CAR-T"/>
</valueReference>
<exclude value="false"/>
</characteristic>
</Group>
</resource>
<request>
<method value="PUT"/>
<url value="Group/mii-exa-mtb-study-cldn6-comparison-group-0"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/EvidenceVariable/mii-exa-mtb-study-cldn6-evidence-variable-0"/>
<resource>
<EvidenceVariable>
<id value="mii-exa-mtb-study-cldn6-evidence-variable-0"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="active"/>
<useContext>
<code>
<system value="http://snomed.info/sct"/>
<code value="362956003"/>
<display value="Procedure/intervention (navigational concept)"/>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="12893009"/>
<display value="Biological"/>
</coding>
</valueCodeableConcept>
</useContext>
<characteristic>
<definitionReference>🔗
<reference
value="Group/mii-exa-mtb-study-cldn6-eligibility-criteria"/>
</definitionReference>
</characteristic>
</EvidenceVariable>
</resource>
<request>
<method value="PUT"/>
<url
value="EvidenceVariable/mii-exa-mtb-study-cldn6-evidence-variable-0"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Group/mii-exa-mtb-study-cldn6-comparison-group-1"/>
<resource>
<Group>
<id value="mii-exa-mtb-study-cldn6-comparison-group-1"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<type value="person"/>
<actual value="false"/>
<characteristic>
<code>
<text value="Exposed to"/>
</code>
<valueReference>🔗
<reference
value="EvidenceVariable/mii-exa-mtb-study-cldn6-evidence-variable-1"/>
<display value="Biological: CLDN6 uRNA-LPX/CLDN6 modRNA-LPX"/>
</valueReference>
<exclude value="false"/>
</characteristic>
</Group>
</resource>
<request>
<method value="PUT"/>
<url value="Group/mii-exa-mtb-study-cldn6-comparison-group-1"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/EvidenceVariable/mii-exa-mtb-study-cldn6-evidence-variable-1"/>
<resource>
<EvidenceVariable>
<id value="mii-exa-mtb-study-cldn6-evidence-variable-1"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="active"/>
<useContext>
<code>
<system value="http://snomed.info/sct"/>
<code value="362956003"/>
<display value="Procedure/intervention (navigational concept)"/>
</code>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="12893009"/>
<display value="Biological"/>
</coding>
</valueCodeableConcept>
</useContext>
<characteristic>
<definitionReference>🔗
<reference
value="Group/mii-exa-mtb-study-cldn6-eligibility-criteria"/>
</definitionReference>
</characteristic>
</EvidenceVariable>
</resource>
<request>
<method value="PUT"/>
<url
value="EvidenceVariable/mii-exa-mtb-study-cldn6-evidence-variable-1"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Organization/mii-exa-mtb-study-sponsor-biontech"/>
<resource>
<Organization>
<id value="mii-exa-mtb-study-sponsor-biontech"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<type>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/organization-type"/>
<code value="crs"/>
<display value="Clinical Research Sponsor"/>
</coding>
</type>
<name value="BioNTech Cell & Gene Therapies GmbH"/>
</Organization>
</resource>
<request>
<method value="PUT"/>
<url value="Organization/mii-exa-mtb-study-sponsor-biontech"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/PractitionerRole/mii-exa-mtb-study-investigator-biontech"/>
<resource>
<PractitionerRole>
<id value="mii-exa-mtb-study-investigator-biontech"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/modul-studie/StructureDefinition/mii-pr-studie-beteiligte-person"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="768734005"/>
<display value="Study coordinator"/>
</coding>
</code>
</PractitionerRole>
</resource>
<request>
<method value="PUT"/>
<url value="PractitionerRole/mii-exa-mtb-study-investigator-biontech"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-0"/>
<resource>
<Location>
<id value="mii-exa-mtb-study-cldn6-location-0"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<name value="Peter MacCallum Cancer Centre"/>
<address>
<city value="Melbourne"/>
<state value="Victoria"/>
<postalCode value="3000"/>
<country value="Australia"/>
</address>
<position>
<longitude value="144.96332"/>
<latitude value="-37.814"/>
</position>
</Location>
</resource>
<request>
<method value="PUT"/>
<url value="Location/mii-exa-mtb-study-cldn6-location-0"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-1"/>
<resource>
<Location>
<id value="mii-exa-mtb-study-cldn6-location-1"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<name
value="Charité - Universitätsmedizin Berlin - Campus Benjamin Franklin"/>
<address>
<city value="Berlin"/>
<postalCode value="12200"/>
<country value="Germany"/>
</address>
<position>
<longitude value="13.41053"/>
<latitude value="52.52437"/>
</position>
</Location>
</resource>
<request>
<method value="PUT"/>
<url value="Location/mii-exa-mtb-study-cldn6-location-1"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-2"/>
<resource>
<Location>
<id value="mii-exa-mtb-study-cldn6-location-2"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<name
value="Universitätsklinikum Erlangen - Hämatologie & Intrinsische Onkologie - Medizinische Klinik 5"/>
<address>
<city value="Erlangen"/>
<postalCode value="91054"/>
<country value="Germany"/>
</address>
<position>
<longitude value="11.00783"/>
<latitude value="49.59099"/>
</position>
</Location>
</resource>
<request>
<method value="PUT"/>
<url value="Location/mii-exa-mtb-study-cldn6-location-2"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-3"/>
<resource>
<Location>
<id value="mii-exa-mtb-study-cldn6-location-3"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<name
value="Universitätsklinikum Hamburg Eppendorf - II Medizinische Klinik und Poliklinik"/>
<address>
<city value="Hamburg"/>
<postalCode value="20246"/>
<country value="Germany"/>
</address>
<position>
<longitude value="10.01534"/>
<latitude value="53.57532"/>
</position>
</Location>
</resource>
<request>
<method value="PUT"/>
<url value="Location/mii-exa-mtb-study-cldn6-location-3"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-4"/>
<resource>
<Location>
<id value="mii-exa-mtb-study-cldn6-location-4"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<name
value="Medizinische Hochschule Hannover - Klinik für Hämatologie, Hämostaseologie, Onkologie und Stammzelltransplantation"/>
<address>
<city value="Hannover"/>
<postalCode value="30625"/>
<country value="Germany"/>
</address>
<position>
<longitude value="9.73322"/>
<latitude value="52.37052"/>
</position>
</Location>
</resource>
<request>
<method value="PUT"/>
<url value="Location/mii-exa-mtb-study-cldn6-location-4"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-5"/>
<resource>
<Location>
<id value="mii-exa-mtb-study-cldn6-location-5"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<name
value="Nationales Centrum für Tumorerkrankungen (NCT) Heidelberg"/>
<address>
<city value="Heidelberg"/>
<postalCode value="69120"/>
<country value="Germany"/>
</address>
<position>
<longitude value="8.69079"/>
<latitude value="49.40768"/>
</position>
</Location>
</resource>
<request>
<method value="PUT"/>
<url value="Location/mii-exa-mtb-study-cldn6-location-5"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-6"/>
<resource>
<Location>
<id value="mii-exa-mtb-study-cldn6-location-6"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<name
value="Universitätsklinikum Köln AÖR-Centrum für Integrierte Onkologie (CIO)-Studienzentrum der Klinik I für Innere Medizin (CTU Cologne)"/>
<address>
<city value="Köln"/>
<postalCode value="50937"/>
<country value="Germany"/>
</address>
<position>
<longitude value="6.95"/>
<latitude value="50.93333"/>
</position>
</Location>
</resource>
<request>
<method value="PUT"/>
<url value="Location/mii-exa-mtb-study-cldn6-location-6"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-7"/>
<resource>
<Location>
<id value="mii-exa-mtb-study-cldn6-location-7"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<name
value="Universitätsmedizin Mainz - III Medizinische Klinik und Poliklinik"/>
<address>
<city value="Mainz"/>
<postalCode value="55131"/>
<country value="Germany"/>
</address>
<position>
<longitude value="8.2791"/>
<latitude value="49.98419"/>
</position>
</Location>
</resource>
<request>
<method value="PUT"/>
<url value="Location/mii-exa-mtb-study-cldn6-location-7"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-8"/>
<resource>
<Location>
<id value="mii-exa-mtb-study-cldn6-location-8"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<name
value="Universitätsklinikum Regensburg - Klinik und Poliklinik für Innere Medizin III"/>
<address>
<city value="Regensburg"/>
<postalCode value="93053"/>
<country value="Germany"/>
</address>
<position>
<longitude value="12.10161"/>
<latitude value="49.01513"/>
</position>
</Location>
</resource>
<request>
<method value="PUT"/>
<url value="Location/mii-exa-mtb-study-cldn6-location-8"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-9"/>
<resource>
<Location>
<id value="mii-exa-mtb-study-cldn6-location-9"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<name
value="He Nederlands Kanker Instituut (The Netherlands Cancer Institute) - Antoni van Leeuwenhoek Ziekenhuis (NKI-AVL)"/>
<address>
<city value="Amsterdam"/>
<postalCode value="1066"/>
<country value="Netherlands"/>
</address>
<position>
<longitude value="4.88969"/>
<latitude value="52.37403"/>
</position>
</Location>
</resource>
<request>
<method value="PUT"/>
<url value="Location/mii-exa-mtb-study-cldn6-location-9"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-10"/>
<resource>
<Location>
<id value="mii-exa-mtb-study-cldn6-location-10"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<name
value="Erasmus MC - Universitair Medisch Centrum - Medical oncology"/>
<address>
<city value="Rotterdam"/>
<postalCode value="3015"/>
<country value="Netherlands"/>
</address>
<position>
<longitude value="4.47917"/>
<latitude value="51.9225"/>
</position>
</Location>
</resource>
<request>
<method value="PUT"/>
<url value="Location/mii-exa-mtb-study-cldn6-location-10"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-11"/>
<resource>
<Location>
<id value="mii-exa-mtb-study-cldn6-location-11"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<name
value="Karolinska Comprehensive Cancer Center Cancerstudieenheten Huddinge Karolinska Universitetssjukhuset"/>
<address>
<city value="Stockholm"/>
<postalCode value="14186"/>
<country value="Sweden"/>
</address>
<position>
<longitude value="18.0649"/>
<latitude value="59.33258"/>
</position>
</Location>
</resource>
<request>
<method value="PUT"/>
<url value="Location/mii-exa-mtb-study-cldn6-location-11"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/ResearchStudy/mii-exa-mtb-study-tedova"/>
<resource>
<ResearchStudy>
<id value="mii-exa-mtb-study-tedova"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-studie|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<identifier>
<system
value="https://www.medizininformatik-initiative.de/fhir/modul-mtb/sid/nct"/>
<value value="04713514"/>
</identifier>
<status value="active"/>
</ResearchStudy>
</resource>
<request>
<method value="PUT"/>
<url value="ResearchStudy/mii-exa-mtb-study-tedova"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/ServiceRequest/mii-exa-mtb-study-request-tedova"/>
<resource>
<ServiceRequest>
<id value="mii-exa-mtb-study-request-tedova"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-studieneinschluss-anfrage|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="extensions"/>
</text>
<extension
url="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-prioritaet">
<valueDecimal value="2.2"/>
</extension>
<status value="draft"/>
<intent value="proposal"/>
<category>
<coding>
<system value="http://snomed.info/sct"/>
<code value="110465008"/>
<display value="Clinical trial (procedure)"/>
</coding>
</category>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="702475000"/>
<display value="Referral to clinical trial (procedure)"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<supportingInfo>🔗
<reference value="ResearchStudy/mii-exa-mtb-study-tedova"/>
</supportingInfo>
</ServiceRequest>
</resource>
<request>
<method value="PUT"/>
<url value="ServiceRequest/mii-exa-mtb-study-request-tedova"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/ResearchStudy/mii-exa-mtb-study-ccne1"/>
<resource>
<ResearchStudy>
<id value="mii-exa-mtb-study-ccne1"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-studie|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="active"/>
</ResearchStudy>
</resource>
<request>
<method value="PUT"/>
<url value="ResearchStudy/mii-exa-mtb-study-ccne1"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/ServiceRequest/mii-exa-mtb-study-request-ccne1"/>
<resource>
<ServiceRequest>
<id value="mii-exa-mtb-study-request-ccne1"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-studieneinschluss-anfrage|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="extensions"/>
</text>
<extension
url="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-prioritaet">
<valueDecimal value="2.3"/>
</extension>
<status value="draft"/>
<intent value="proposal"/>
<category>
<coding>
<system value="http://snomed.info/sct"/>
<code value="110465008"/>
<display value="Clinical trial (procedure)"/>
</coding>
</category>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="702475000"/>
<display value="Referral to clinical trial (procedure)"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<supportingInfo>🔗
<reference value="ResearchStudy/mii-exa-mtb-study-ccne1"/>
</supportingInfo>
</ServiceRequest>
</resource>
<request>
<method value="PUT"/>
<url value="ServiceRequest/mii-exa-mtb-study-request-ccne1"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"/>
<resource>
<MedicationRequest>
<id value="mii-exa-mtb-medication-request-mirvetuximab"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="extensions"/>
</text>
<extension
url="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-prioritaet">
<valuePositiveInt value="1"/>
</extension>
<extension
url="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-evidenzgraduierung">
<valueCodeableConcept>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-empfehlung-evidenzgrad"/>
<code value="m1A"/>
</coding>
</valueCodeableConcept>
</extension>
<extension
url="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-publikation">
<valueIdentifier>
<system value="http://doi.org"/>
<value value="10.1200/JCO.2022.40.16_suppl.5512"/>
</valueIdentifier>
</extension>
<extension
url="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-publikation">
<valueIdentifier>
<system value="http://www.ncbi.nlm.nih.gov/pubmed"/>
<value value="38055253"/>
</valueIdentifier>
</extension>
<status value="completed"/>
<intent value="proposal"/>
<medicationCodeableConcept>
<coding>
<system value="http://fdasis.nlm.nih.gov"/>
<code value="98DE7VN88D"/>
<display value="MIRVETUXIMAB SORAVTANSINE"/>
</coding>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<version value="2025"/>
<code value="L01FX26"/>
<display value="Mirvetuximab soravtansin"/>
</coding>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<version value="2025"/>
<code value="L01FX"/>
<display
value="Andere monoklonale Antikörper und Antikörper-Wirkstoff-Konjugate"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<authoredOn value="2023-03-28"/>
<reasonReference>🔗
<reference
value="Condition/PatientKimMusterperson-PrimaryDiagnosis-2"/>
</reasonReference>
<basedOn>🔗
<reference
value="CarePlan/mii-exa-mtb-kim-musterperson-therapieplan"/>
</basedOn>
</MedicationRequest>
</resource>
<request>
<method value="PUT"/>
<url
value="MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationRequest/mii-exa-mtb-medication-request-trastuzumab-deruxtecan"/>
<resource>
<MedicationRequest>
<id value="mii-exa-mtb-medication-request-trastuzumab-deruxtecan"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="extensions"/>
</text>
<extension
url="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-prioritaet">
<valuePositiveInt value="3"/>
</extension>
<extension
url="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-evidenzgraduierung">
<valueCodeableConcept>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-empfehlung-evidenzgrad"/>
<code value="m1B"/>
</coding>
</valueCodeableConcept>
</extension>
<extension
url="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-publikation">
<valueIdentifier>
<system value="http://www.ncbi.nlm.nih.gov/pubmed"/>
<value value="35665782"/>
</valueIdentifier>
</extension>
<extension
url="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-publikation">
<valueIdentifier>
<system value="http://www.ncbi.nlm.nih.gov/pubmed"/>
<value value="37870536"/>
</valueIdentifier>
</extension>
<extension
url="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-publikation">
<valueIdentifier>
<system value="http://doi.org"/>
<value value="10.1200/JCO.2023.41.17_suppl.LBA3000"/>
</valueIdentifier>
</extension>
<status value="draft"/>
<intent value="proposal"/>
<medicationCodeableConcept>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<version value="2025"/>
<code value="L01FD04"/>
<display value="Trastuzumab deruxtecan"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<authoredOn value="2023-03-28"/>
<reasonReference>🔗
<reference
value="Condition/PatientKimMusterperson-PrimaryDiagnosis-2"/>
</reasonReference>
</MedicationRequest>
</resource>
<request>
<method value="PUT"/>
<url
value="MedicationRequest/mii-exa-mtb-medication-request-trastuzumab-deruxtecan"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationRequest/mii-exa-mtb-medication-request-adavosertib"/>
<resource>
<MedicationRequest>
<id value="mii-exa-mtb-medication-request-adavosertib"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="draft"/>
<intent value="option"/>
<medicationCodeableConcept>
<coding>
<system value="http://fdasis.nlm.nih.gov"/>
<code value="K2T6HJX3I3"/>
<display value="ADAVOSERTIB"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<authoredOn value="2023-03-28"/>
<reasonReference>🔗
<reference
value="Condition/PatientKimMusterperson-PrimaryDiagnosis-2"/>
</reasonReference>
</MedicationRequest>
</resource>
<request>
<method value="PUT"/>
<url
value="MedicationRequest/mii-exa-mtb-medication-request-adavosertib"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationRequest/mii-exa-mtb-medication-request-carboplatin"/>
<resource>
<MedicationRequest>
<id value="mii-exa-mtb-medication-request-carboplatin"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="draft"/>
<intent value="option"/>
<medicationCodeableConcept>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<version value="2025"/>
<code value="L01XA02"/>
<display value="Carboplatin"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<authoredOn value="2023-03-28"/>
<reasonReference>🔗
<reference
value="Condition/PatientKimMusterperson-PrimaryDiagnosis-2"/>
</reasonReference>
</MedicationRequest>
</resource>
<request>
<method value="PUT"/>
<url
value="MedicationRequest/mii-exa-mtb-medication-request-carboplatin"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/RequestGroup/mii-exa-mtb-request-group-adavosertib-carboplatin"/>
<resource>
<RequestGroup>
<id value="mii-exa-mtb-request-group-adavosertib-carboplatin"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung-kombination|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="extensions"/>
</text>
<extension
url="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-prioritaet">
<valuePositiveInt value="4"/>
</extension>
<extension
url="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-evidenzgraduierung">
<valueCodeableConcept>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-empfehlung-evidenzgrad"/>
<code value="m1B"/>
</coding>
</valueCodeableConcept>
</extension>
<extension
url="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-publikation">
<valueIdentifier>
<system value="http://www.ncbi.nlm.nih.gov/pubmed"/>
<value value="37236033"/>
</valueIdentifier>
</extension>
<status value="draft"/>
<intent value="proposal"/>
<code>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-therapie-typ"/>
<code value="CZ"/>
<display value="Chemotherapie + zielgerichtete Substanzen"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<authoredOn value="2023-03-28"/>
<action>
<resource>🔗
<reference
value="MedicationRequest/mii-exa-mtb-medication-request-carboplatin"/>
</resource>
</action>
</RequestGroup>
</resource>
<request>
<method value="PUT"/>
<url
value="RequestGroup/mii-exa-mtb-request-group-adavosertib-carboplatin"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationRequest/mii-exa-mtb-medication-request-lunresertib"/>
<resource>
<MedicationRequest>
<id value="mii-exa-mtb-medication-request-lunresertib"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="draft"/>
<intent value="option"/>
<medicationCodeableConcept>
<coding>
<system value="http://fdasis.nlm.nih.gov"/>
<code value="N95U3A7N57"/>
<display value="LUNRESERTIB"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<authoredOn value="2023-03-28"/>
<reasonReference>🔗
<reference
value="Condition/PatientKimMusterperson-PrimaryDiagnosis-2"/>
</reasonReference>
</MedicationRequest>
</resource>
<request>
<method value="PUT"/>
<url
value="MedicationRequest/mii-exa-mtb-medication-request-lunresertib"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationRequest/mii-exa-mtb-medication-request-camonsertib"/>
<resource>
<MedicationRequest>
<id value="mii-exa-mtb-medication-request-camonsertib"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="draft"/>
<intent value="option"/>
<medicationCodeableConcept>
<coding>
<system value="http://fdasis.nlm.nih.gov"/>
<code value="S1Z7Y5G56T"/>
<display value="CAMONSERTIB"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<authoredOn value="2023-03-28"/>
<reasonReference>🔗
<reference
value="Condition/PatientKimMusterperson-PrimaryDiagnosis-2"/>
</reasonReference>
</MedicationRequest>
</resource>
<request>
<method value="PUT"/>
<url
value="MedicationRequest/mii-exa-mtb-medication-request-camonsertib"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/RequestGroup/mii-exa-mtb-request-group-lunresertib-camonsertib"/>
<resource>
<RequestGroup>
<id value="mii-exa-mtb-request-group-lunresertib-camonsertib"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung-kombination|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="extensions"/>
</text>
<extension
url="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-prioritaet">
<valuePositiveInt value="5"/>
</extension>
<extension
url="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-evidenzgraduierung">
<valueCodeableConcept>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-empfehlung-evidenzgrad"/>
<code value="m1B"/>
</coding>
</valueCodeableConcept>
</extension>
<extension
url="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-publikation">
<valueIdentifier>
<system value="http://doi.org"/>
<value value="10.1158/1535-7163.TARG-23-PR008"/>
</valueIdentifier>
</extension>
<status value="draft"/>
<intent value="proposal"/>
<code>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-therapie-typ"/>
<code value="ZS"/>
<display value="zielgerichtete Substanzen"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<authoredOn value="2023-03-28"/>
<action>
<resource>🔗
<reference
value="MedicationRequest/mii-exa-mtb-medication-request-camonsertib"/>
</resource>
</action>
</RequestGroup>
</resource>
<request>
<method value="PUT"/>
<url
value="RequestGroup/mii-exa-mtb-request-group-lunresertib-camonsertib"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/MedicationRequest/mii-exa-mtb-medication-request-cobimetinib"/>
<resource>
<MedicationRequest>
<id value="mii-exa-mtb-medication-request-cobimetinib"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="extensions"/>
</text>
<extension
url="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-prioritaet">
<valuePositiveInt value="6"/>
</extension>
<extension
url="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-evidenzgraduierung">
<valueCodeableConcept>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-empfehlung-evidenzgrad"/>
<code value="m3"/>
</coding>
</valueCodeableConcept>
</extension>
<extension
url="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-publikation">
<valueIdentifier>
<system value="http://www.ncbi.nlm.nih.gov/pubmed"/>
<value value="31209687"/>
</valueIdentifier>
</extension>
<status value="draft"/>
<intent value="option"/>
<medicationCodeableConcept>
<coding>
<system value="http://fdasis.nlm.nih.gov"/>
<code value="ER29L26N1X"/>
<display value="COBIMETINIB"/>
</coding>
</medicationCodeableConcept>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<authoredOn value="2023-03-28"/>
<reasonReference>🔗
<reference
value="Condition/PatientKimMusterperson-PrimaryDiagnosis-2"/>
</reasonReference>
</MedicationRequest>
</resource>
<request>
<method value="PUT"/>
<url
value="MedicationRequest/mii-exa-mtb-medication-request-cobimetinib"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/CarePlan/mii-exa-mtb-kim-musterperson-therapieplan"/>
<resource>
<CarePlan>
<id value="mii-exa-mtb-kim-musterperson-therapieplan"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieplan|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="active"/>
<intent value="plan"/>
<category>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-therapieplanung-typ"/>
<code value="praeth"/>
</coding>
</category>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<created value="2023-03-28"/>
<addresses>🔗
<reference
value="Condition/PatientKimMusterperson-PrimaryDiagnosis-2"/>
</addresses>
<supportingInfo>🔗
<reference
value="ClinicalImpression/mii-exa-mtb-kim-musterperson-behandlungsepisode"/>
</supportingInfo>
<activity>
<outcomeReference>🔗
<reference value="Procedure/MTBChemo2Procedure"/>
</outcomeReference>
<reference>🔗
<reference
value="MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"/>
</reference>
</activity>
<activity>
<reference>🔗
<reference
value="ServiceRequest/mii-exa-mtb-study-request-cldn6"/>
</reference>
</activity>
<activity>
<reference>🔗
<reference
value="ServiceRequest/mii-exa-mtb-study-request-tedova"/>
</reference>
</activity>
<activity>
<reference>🔗
<reference
value="ServiceRequest/mii-exa-mtb-study-request-ccne1"/>
</reference>
</activity>
<activity>
<reference>🔗
<reference
value="MedicationRequest/mii-exa-mtb-medication-request-trastuzumab-deruxtecan"/>
</reference>
</activity>
<activity>
<reference>🔗
<reference
value="RequestGroup/mii-exa-mtb-request-group-adavosertib-carboplatin"/>
</reference>
</activity>
<activity>
<reference>🔗
<reference
value="RequestGroup/mii-exa-mtb-request-group-lunresertib-camonsertib"/>
</reference>
</activity>
<activity>
<reference>🔗
<reference
value="MedicationRequest/mii-exa-mtb-medication-request-cobimetinib"/>
</reference>
</activity>
<activity>
<reference>🔗
<reference
value="ServiceRequest/mii-exa-mtb-kim-humangenetische-beratung-aszites"/>
</reference>
</activity>
<activity>
<reference>🔗
<reference
value="ServiceRequest/mii-exa-mtb-kim-histologie-evaluation-aszites"/>
</reference>
</activity>
<activity>
<reference>🔗
<reference
value="ServiceRequest/mii-exa-mtb-kim-rebiopsie-aszites"/>
</reference>
</activity>
</CarePlan>
</resource>
<request>
<method value="PUT"/>
<url value="CarePlan/mii-exa-mtb-kim-musterperson-therapieplan"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/mii-exa-mtb-kim-tumorzellgehalt-aszites"/>
<resource>
<Observation>
<id value="mii-exa-mtb-kim-tumorzellgehalt-aszites"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-tumorzellgehalt|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="final"/>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="93356-4"/>
<display
value="Cells with cytogenetic abnormality [#] in Blood or Tissue by Molecular genetics method"/>
</coding>
</code>
<valueQuantity>
<value value="0.028"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<method>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-bestimmungsmethode-tumorzellgehalt"/>
<code value="histologic"/>
</coding>
</method>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/mii-exa-mtb-kim-tumorzellgehalt-aszites"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/ServiceRequest/mii-exa-mtb-kim-humangenetische-beratung-aszites"/>
<resource>
<ServiceRequest>
<id value="mii-exa-mtb-kim-humangenetische-beratung-aszites"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-humangenetische-beratung-auftrag|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="completed"/>
<intent value="proposal"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="788339009"/>
<display value="Genetic consultation (procedure)"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<reasonCode>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-auftrag-begruendung"/>
<code value="secondary-tumor"/>
</coding>
</reasonCode>
<specimen>🔗
<reference
value="Specimen/PatientKimMusterperson-AscitesSpecimen-2"/>
</specimen>
</ServiceRequest>
</resource>
<request>
<method value="PUT"/>
<url
value="ServiceRequest/mii-exa-mtb-kim-humangenetische-beratung-aszites"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/ServiceRequest/mii-exa-mtb-kim-histologie-evaluation-aszites"/>
<resource>
<ServiceRequest>
<id value="mii-exa-mtb-kim-histologie-evaluation-aszites"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-histologie-evaluation-auftrag|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="draft"/>
<intent value="proposal"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="183825009"/>
<display value="Refer for histology (procedure)"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<reasonReference>🔗
<reference
value="Observation/mii-exa-mtb-kim-tumorzellgehalt-aszites"/>
</reasonReference>
<specimen>🔗
<reference
value="Specimen/PatientKimMusterperson-AscitesSpecimen-2"/>
</specimen>
</ServiceRequest>
</resource>
<request>
<method value="PUT"/>
<url
value="ServiceRequest/mii-exa-mtb-kim-histologie-evaluation-aszites"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/ServiceRequest/mii-exa-mtb-kim-rebiopsie-aszites"/>
<resource>
<ServiceRequest>
<id value="mii-exa-mtb-kim-rebiopsie-aszites"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-biopsie-auftrag|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="completed"/>
<intent value="proposal"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="86273004"/>
<display value="Biopsy (procedure)"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<reasonReference>🔗
<reference
value="Observation/mii-exa-mtb-kim-tumorzellgehalt-aszites"/>
</reasonReference>
<specimen>🔗
<reference
value="Specimen/PatientKimMusterperson-AscitesSpecimen-2"/>
</specimen>
</ServiceRequest>
</resource>
<request>
<method value="PUT"/>
<url value="ServiceRequest/mii-exa-mtb-kim-rebiopsie-aszites"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Condition/mii-exa-mtb-kim-diagnose"/>
<resource>
<Condition>
<id value="mii-exa-mtb-kim-diagnose"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-diagnose-primaertumor|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="extensions"/>
</text>
<extension
url="http://hl7.org/fhir/StructureDefinition/condition-assertedDate">
<valueDateTime value="2021-06-10"/>
</extension>
<clinicalStatus>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/condition-clinical"/>
<code value="active"/>
</coding>
</clinicalStatus>
<verificationStatus>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/condition-ver-status"/>
<code value="unconfirmed"/>
</coding>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-primaertumor-diagnosesicherung"/>
<code value="2"/>
</coding>
</verificationStatus>
<category>
<coding>
<system value="http://snomed.info/sct"/>
<code value="55342001"/>
<display value="Neoplastic disease"/>
</coding>
</category>
<code>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/icd-10-gm"/>
<version value="2023"/>
<code value="C48.2"/>
<display
value="Bösartige Neubildung: Peritoneum, nicht näher bezeichnet"/>
</coding>
</code>
<bodySite>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/icd-o-3"/>
<code value="C56.9"/>
<display value="Ovar"/>
</coding>
</bodySite>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<recordedDate value="2021-06-10"/>
<stage>
<assessment>🔗
<reference value="Observation/mii-exa-mtb-kim-tumorausbreitung"/>
</assessment>
<type>
<coding>
<system
value="https://nih-ncpi.github.io/ncpi-fhir-ig/CodeSystem-ncit.html"/>
<code value="C19251"/>
<display value="Stage at Diagnosis"/>
</coding>
</type>
</stage>
<stage>
<assessment>🔗
<reference value="Observation/mii-exa-mtb-kim-oncotree"/>
</assessment>
<type>
<coding>
<system value="http://snomed.info/sct"/>
<code value="371441004"/>
<display value="Histologic type of proliferative mass"/>
</coding>
</type>
</stage>
</Condition>
</resource>
<request>
<method value="PUT"/>
<url value="Condition/mii-exa-mtb-kim-diagnose"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/mii-exa-mtb-kim-tumorausbreitung"/>
<resource>
<Observation>
<id value="mii-exa-mtb-kim-tumorausbreitung"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-tumorausbreitung|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="final"/>
<category>
<coding>
<system value="http://snomed.info/sct"/>
<code value="473302008"/>
<display value="Aware of diagnosis"/>
</coding>
</category>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="371508000"/>
<display value="Tumor stage"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2021-06-10"/>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="255127006"/>
</coding>
</valueCodeableConcept>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/mii-exa-mtb-kim-tumorausbreitung"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/mii-exa-mtb-kim-oncotree"/>
<resource>
<Observation>
<id value="mii-exa-mtb-kim-oncotree"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-oncotree|2027.0.0-ballot.1"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="371469007"/>
<display
value="Histologic grade of neoplasm (observable entity)"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<effectiveDateTime value="2021-06-10"/>
<valueCodeableConcept>
<coding>
<system value="http://data.mskcc.org/ontologies/oncotree"/>
<code value="HGONEC"/>
</coding>
</valueCodeableConcept>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url value="Observation/mii-exa-mtb-kim-oncotree"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Condition/PatientKimMusterperson-PrimaryDiagnosis-2"/>
<resource>
<Condition>
<id value="PatientKimMusterperson-PrimaryDiagnosis-2"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-diagnose-primaertumor"/>
</meta>
<language value="de"/>
<text>
<status value="extensions"/>
</text>
<extension
url="http://hl7.org/fhir/StructureDefinition/condition-assertedDate">
<valueDateTime value="2021-06-10"/>
</extension>
<clinicalStatus>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/condition-clinical"/>
<code value="active"/>
</coding>
</clinicalStatus>
<verificationStatus>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/condition-ver-status"/>
<code value="unconfirmed"/>
</coding>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-primaertumor-diagnosesicherung"/>
<code value="2"/>
</coding>
</verificationStatus>
<category>
<coding>
<system value="http://snomed.info/sct"/>
<code value="55342001"/>
<display value="Neoplastic disease"/>
</coding>
</category>
<code>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/icd-10-gm"/>
<version value="2020"/>
<code value="C48.2"/>
<display
value="Bösartige Neubildung: Peritoneum, nicht näher bezeichnet"/>
</coding>
</code>
<bodySite>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/icd-o-3"/>
<code value="C56.9"/>
<display value="Ovar"/>
</coding>
</bodySite>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<recordedDate value="2021-06-10"/>
</Condition>
</resource>
<request>
<method value="PUT"/>
<url value="Condition/PatientKimMusterperson-PrimaryDiagnosis-2"/>
</request>
</entry>
<entry>
<fullUrl
value="http://example.org/fhir/Observation/mii-exa-onko-allgemeiner-leistungszustand-ecog"/>
<resource>
<Observation>
<id value="mii-exa-onko-allgemeiner-leistungszustand-ecog"/>
<meta>
<profile
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-allgemeiner-leistungszustand-ecog"/>
</meta>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="final"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="423740007"/>
</coding>
</code>
<subject>🔗
<reference value="Patient/PatientKimMusterperson"/>
</subject>
<valueCodeableConcept>
<coding>
<system
value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-allgemeiner-leistungszustand-ecog"/>
<code value="2"/>
<display
value="Gehfähig, Selbstversorgung möglich, aber nicht arbeitsfähig; kann mehr als 50 % der Wachzeit aufstehen (50 - 60 % nach Karnofsky)"/>
</coding>
</valueCodeableConcept>
</Observation>
</resource>
<request>
<method value="PUT"/>
<url
value="Observation/mii-exa-onko-allgemeiner-leistungszustand-ecog"/>
</request>
</entry>
<entry>
<fullUrl value="http://example.org/fhir/Organization/MyHospital"/>
<resource>
<Organization>
<id value="MyHospital"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<type>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/organization-type"/>
<code value="prov"/>
<display value="Healthcare Provider"/>
</coding>
</type>
<name value="Example General Hospital"/>
<address>
<line value="1234 Health St"/>
<city value="Medicity"/>
<state value="CareState"/>
<postalCode value="12345"/>
<country value="DE"/>
</address>
</Organization>
</resource>
<request>
<method value="PUT"/>
<url value="Organization/MyHospital"/>
</request>
</entry>
<entry>
<fullUrl value="http://example.org/fhir/Organization/MyInsurer"/>
<resource>
<Organization>
<id value="MyInsurer"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<type>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/organization-type"/>
<code value="ins"/>
<display value="Insurance Company"/>
</coding>
</type>
<name value="Example Health Insurance Co."/>
<address>
<line value="789 Insurance Blvd"/>
<city value="Policytown"/>
<state value="InsureState"/>
<postalCode value="98765"/>
<country value="DE"/>
</address>
</Organization>
</resource>
<request>
<method value="PUT"/>
<url value="Organization/MyInsurer"/>
</request>
</entry>
<entry>
<fullUrl value="http://example.org/fhir/Coverage/MyCoverage"/>
<resource>
<Coverage>
<id value="MyCoverage"/>
<language value="de"/>
<text>
<status value="generated"/>
</text>
<status value="active"/>
<type>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v3-ActCode"/>
<code value="EHCPOL"/>
<display value="extended healthcare"/>
</coding>
</type>
<beneficiary>🔗
<reference value="Patient/PatientKimMusterperson"/>
</beneficiary>
<period>
<start value="2023-01-01"/>
<end value="2025-12-31"/>
</period>
<payor>🔗
<reference value="Organization/MyInsurer"/>
</payor>
</Coverage>
</resource>
<request>
<method value="PUT"/>
<url value="Coverage/MyCoverage"/>
</request>
</entry>
</Bundle>