<?xml version="1.0" encoding="UTF-8"?>

<Bundle xmlns="http://hl7.org/fhir">
  <id value="mii-exa-onko-prostata-example-bundle-1"/>
  <meta>
    <profile value="http://hl7.org/fhir/StructureDefinition/Bundle"/>
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  <language value="de"/>
  <identifier>
    <system value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko"/>
    <value value="prostata-example-bundle-2024-001"/>
  </identifier>
  <type value="transaction"/>
  <timestamp value="2024-03-25T10:00:00+01:00"/>
  <entry>
    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/Patient/mii-exa-onko-prostata-bundle-patient"/>
    <resource>
      <Patient>
        <id value="mii-exa-onko-prostata-bundle-patient"/>
        <language value="de"/>
        <text>
          <status value="generated"/>
        </text>
        <name>
          <family value="ProstataCa"/>
          <given value="Peter"/>
        </name>
      </Patient>
    </resource>
    <request>
      <method value="POST"/>
      <url value="Patient"/>
    </request>
  </entry>
  <entry>
    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/Condition/mii-exa-onko-prostata-diagnose"/>
    <resource>
      <Condition>
        <id value="mii-exa-onko-prostata-diagnose"/>
        <meta>
          <profile value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-diagnose-primaertumor|2027.0.0-ballot.1"/>
        </meta>
        <language value="de"/>
        <text>
          <status value="extensions"/>
        </text>
        <extension url="http://hl7.org/fhir/StructureDefinition/condition-assertedDate">
          <valueDateTime value="2020-03-07"/>
        </extension>
        <clinicalStatus>
          <coding>
            <system value="http://terminology.hl7.org/CodeSystem/condition-clinical"/>
            <code value="active"/>
          </coding>
        </clinicalStatus>
        <verificationStatus>
          <coding>
            <system value="http://terminology.hl7.org/CodeSystem/condition-ver-status"/>
            <code value="confirmed"/>
          </coding>
        </verificationStatus>
        <category>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="55342001"/>
            <display value="Neoplastic disease"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://fhir.de/CodeSystem/bfarm/icd-10-gm"/>
            <version value="2024"/>
            <code value="C61"/>
            <display value="Bösartige Neubildung der Prostata"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/mii-exa-onko-prostata-bundle-patient"/>
        </subject>
        <recordedDate value="2024-01-02"/>
      </Condition>
    </resource>
    <request>
      <method value="POST"/>
      <url value="Condition"/>
    </request>
  </entry>
  <entry>
    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/Encounter/mii-exa-onko-prostata-bundle-encounter"/>
    <resource>
      <Encounter>
        <id value="mii-exa-onko-prostata-bundle-encounter"/>
        <language value="de"/>
        <text>
          <status value="generated"/>
        </text>
        <status value="finished"/>
        <class>
          <system value="http://terminology.hl7.org/CodeSystem/v3-ActCode"/>
          <code value="IMP"/>
          <display value="inpatient encounter"/>
        </class>
        <subject>
          <reference value="Patient/mii-exa-onko-prostata-bundle-patient"/>
        </subject>
      </Encounter>
    </resource>
    <request>
      <method value="POST"/>
      <url value="Encounter"/>
    </request>
  </entry>
  <entry>
    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/Observation/mii-exa-onko-prostata-psa-diagnose-1"/>
    <resource>
      <Observation>
        <id value="mii-exa-onko-prostata-psa-diagnose-1"/>
        <meta>
          <profile value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-prostate-psa|2027.0.0-ballot.1"/>
        </meta>
        <language value="de"/>
        <text>
          <status value="generated"/>
        </text>
        <status value="final"/>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="2857-1"/>
            <display value="Prostate specific Ag [Mass/volume] in Serum or Plasma"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/mii-exa-onko-prostata-bundle-patient"/>
        </subject>
        <focus>
          <reference value="Condition/mii-exa-onko-prostata-diagnose"/>
        </focus>
        <effectiveDateTime value="2024-01-02"/>
        <valueQuantity>
          <value value="12"/>
          <unit value="ng/ml"/>
        </valueQuantity>
      </Observation>
    </resource>
    <request>
      <method value="POST"/>
      <url value="Observation"/>
    </request>
  </entry>
  <entry>
    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/Observation/mii-exa-onko-prostata-anzahl-stanzen-1"/>
    <resource>
      <Observation>
        <id value="mii-exa-onko-prostata-anzahl-stanzen-1"/>
        <meta>
          <profile value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-prostate-anzahl-stanzen|2027.0.0-ballot.1"/>
        </meta>
        <language value="de"/>
        <text>
          <status value="generated"/>
        </text>
        <status value="final"/>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="44652-6"/>
            <display value="Total number of cores in Tissue core"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/mii-exa-onko-prostata-bundle-patient"/>
        </subject>
        <focus>
          <reference value="Condition/mii-exa-onko-prostata-diagnose"/>
        </focus>
        <effectiveDateTime value="2024-01-02"/>
        <valueInteger value="12"/>
      </Observation>
    </resource>
    <request>
      <method value="POST"/>
      <url value="Observation"/>
    </request>
  </entry>
  <entry>
    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/Observation/mii-exa-onko-prostata-anzahl-positiver-stanzen-1"/>
    <resource>
      <Observation>
        <id value="mii-exa-onko-prostata-anzahl-positiver-stanzen-1"/>
        <meta>
          <profile value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-prostate-anzahl-positive-stanzen|2027.0.0-ballot.1"/>
        </meta>
        <language value="de"/>
        <text>
          <status value="generated"/>
        </text>
        <status value="final"/>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="44651-8"/>
            <display value="Tissue cores.positive.carcinoma in Tissue core"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/mii-exa-onko-prostata-bundle-patient"/>
        </subject>
        <focus>
          <reference value="Condition/mii-exa-onko-prostata-diagnose"/>
        </focus>
        <effectiveDateTime value="2024-01-02"/>
        <valueInteger value="8"/>
      </Observation>
    </resource>
    <request>
      <method value="POST"/>
      <url value="Observation"/>
    </request>
  </entry>
  <entry>
    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/Observation/mii-exa-onko-prostata-ca-befall-stanze-1"/>
    <resource>
      <Observation>
        <id value="mii-exa-onko-prostata-ca-befall-stanze-1"/>
        <meta>
          <profile value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-prostate-ca-befall-stanze|2027.0.0-ballot.1"/>
        </meta>
        <language value="de"/>
        <text>
          <status value="generated"/>
        </text>
        <status value="final"/>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="44654-2"/>
            <display value="Tissue involved by tumor in Prostate tumor"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/mii-exa-onko-prostata-bundle-patient"/>
        </subject>
        <focus>
          <reference value="Condition/mii-exa-onko-prostata-diagnose"/>
        </focus>
        <effectiveDateTime value="2024-01-02"/>
        <valueQuantity>
          <value value="80"/>
          <unit value="%"/>
        </valueQuantity>
        <specimen>
          <reference value="Specimen/mii-exa-onko-prostata-specimen-stanze"/>
        </specimen>
      </Observation>
    </resource>
    <request>
      <method value="POST"/>
      <url value="Observation"/>
    </request>
  </entry>
  <entry>
    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/Observation/mii-exa-onko-prostata-gleason-pattern-grade-group-1"/>
    <resource>
      <Observation>
        <id value="mii-exa-onko-prostata-gleason-pattern-grade-group-1"/>
        <meta>
          <profile value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-prostate-gleason-grade-group|2027.0.0-ballot.1"/>
        </meta>
        <language value="de"/>
        <text>
          <status value="generated"/>
        </text>
        <status value="final"/>
        <code>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="1812491000004107"/>
            <display value="Histologic grade of primary malignant neoplasm of prostate by International Society of Urological Pathology technique (observable entity)"/>
          </coding>
          <coding>
            <system value="http://loinc.org"/>
            <code value="94734-1"/>
            <display value="Prostate cancer grade group [Score] in Prostate tumor Qualitative"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/mii-exa-onko-prostata-bundle-patient"/>
        </subject>
        <focus>
          <reference value="Condition/mii-exa-onko-prostata-diagnose"/>
        </focus>
        <effectiveDateTime value="2024-01-02"/>
        <valueCodeableConcept>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="1279714001"/>
            <display value="International Society of Urological Pathology grade group 2 (Gleason score 3 + 4 = 7) (qualifier value)"/>
          </coding>
        </valueCodeableConcept>
        <derivedFrom>
          <reference value="Observation/mii-exa-onko-prostata-gleason-pattern-primary-1"/>
        </derivedFrom>
        <derivedFrom>
          <reference value="Observation/mii-exa-onko-prostata-gleason-pattern-secondary-1"/>
        </derivedFrom>
      </Observation>
    </resource>
    <request>
      <method value="POST"/>
      <url value="Observation"/>
    </request>
  </entry>
  <entry>
    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/Observation/mii-exa-onko-prostata-gleason-pattern-primary-1"/>
    <resource>
      <Observation>
        <id value="mii-exa-onko-prostata-gleason-pattern-primary-1"/>
        <meta>
          <profile value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-prostate-gleason-patterns|2027.0.0-ballot.1"/>
        </meta>
        <language value="de"/>
        <text>
          <status value="generated"/>
        </text>
        <status value="final"/>
        <code>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="384994009"/>
            <display value="Primary Gleason pattern (observable entity)"/>
          </coding>
          <coding>
            <system value="http://loinc.org"/>
            <code value="44641-9"/>
            <display value="Gleason pattern.primary in Prostate tumor"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/mii-exa-onko-prostata-bundle-patient"/>
        </subject>
        <focus>
          <reference value="Condition/mii-exa-onko-prostata-diagnose"/>
        </focus>
        <effectiveDateTime value="2024-01-02"/>
        <valueCodeableConcept>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="369772003"/>
            <display value="Gleason Pattern 3"/>
          </coding>
        </valueCodeableConcept>
      </Observation>
    </resource>
    <request>
      <method value="POST"/>
      <url value="Observation"/>
    </request>
  </entry>
  <entry>
    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/Observation/mii-exa-onko-prostata-gleason-pattern-secondary-1"/>
    <resource>
      <Observation>
        <id value="mii-exa-onko-prostata-gleason-pattern-secondary-1"/>
        <meta>
          <profile value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-prostate-gleason-patterns|2027.0.0-ballot.1"/>
        </meta>
        <language value="de"/>
        <text>
          <status value="generated"/>
        </text>
        <status value="final"/>
        <code>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="384995005"/>
            <display value="Secondary Gleason pattern (observable entity)"/>
          </coding>
          <coding>
            <system value="http://loinc.org"/>
            <code value="44642-7"/>
            <display value="Gleason pattern.secondary in Prostate tumor"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/mii-exa-onko-prostata-bundle-patient"/>
        </subject>
        <focus>
          <reference value="Condition/mii-exa-onko-prostata-diagnose"/>
        </focus>
        <effectiveDateTime value="2024-01-02"/>
        <valueCodeableConcept>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="369773008"/>
            <display value="Gleason Pattern 4"/>
          </coding>
        </valueCodeableConcept>
      </Observation>
    </resource>
    <request>
      <method value="POST"/>
      <url value="Observation"/>
    </request>
  </entry>
  <entry>
    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/Observation/mii-exa-onko-prostata-surgical-complication-1"/>
    <resource>
      <Observation>
        <id value="mii-exa-onko-prostata-surgical-complication-1"/>
        <meta>
          <profile value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-prostate-clavien-dindo|2027.0.0-ballot.1"/>
        </meta>
        <language value="de"/>
        <text>
          <status value="generated"/>
        </text>
        <status value="final"/>
        <code>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="789279006"/>
            <display value="Clavien-Dindo classification grade (observable entity)"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/mii-exa-onko-prostata-bundle-patient"/>
        </subject>
        <focus>
          <reference value="Condition/mii-exa-onko-prostata-diagnose"/>
        </focus>
        <focus>
          <reference value="Procedure/mii-exa-onko-prostata-surgery-1"/>
        </focus>
        <effectiveDateTime value="2024-06-24"/>
        <valueCodeableConcept>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="1367522003"/>
            <display value="Clavien-Dindo classification grade IIIa (finding)"/>
          </coding>
          <coding>
            <system value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-prostata-postsurgical-complications"/>
            <code value="J"/>
            <display value="Ja"/>
          </coding>
        </valueCodeableConcept>
      </Observation>
    </resource>
    <request>
      <method value="POST"/>
      <url value="Observation"/>
    </request>
  </entry>
  <entry>
    <fullUrl value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/Procedure/mii-exa-onko-prostata-surgery-1"/>
    <resource>
      <Procedure>
        <id value="mii-exa-onko-prostata-surgery-1"/>
        <meta>
          <profile value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-operation|2027.0.0-ballot.1"/>
        </meta>
        <language value="de"/>
        <text>
          <status value="extensions"/>
        </text>
        <extension url="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-ex-onko-operation-intention">
          <valueCodeableConcept>
            <coding>
              <system value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-intention"/>
              <code value="K"/>
              <display value="Kurativ"/>
            </coding>
          </valueCodeableConcept>
        </extension>
        <status value="completed"/>
        <category>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="387713003"/>
            <display value="Surgical procedure"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://fhir.de/CodeSystem/bfarm/ops"/>
            <version value="2024"/>
            <code value="5-604"/>
            <display value="Radikale Prostatovesikulektomie"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/mii-exa-onko-prostata-bundle-patient"/>
        </subject>
        <performedDateTime value="2024-06-24"/>
        <reasonReference>
          <reference value="Condition/mii-exa-onko-prostata-diagnose"/>
        </reasonReference>
      </Procedure>
    </resource>
    <request>
      <method value="POST"/>
      <url value="Procedure"/>
    </request>
  </entry>
</Bundle>