{
  "resourceType" : "MedicationRequest",
  "id" : "mii-exa-onko-modification-oxaliplatin-request",
  "meta" : {
    "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-therapieempfehlung-medikation|2027.0.0-ballot.1"]
  },
  "language" : "de",
  "text" : {
    "status" : "generated",
    "div" : "<div xml:lang=\"de\" lang=\"de\"><hr/><p><b>German</b></p><hr/><p class=\"res-header-id\"><b>Generated Narrative: MedicationRequest mii-exa-onko-modification-oxaliplatin-request</b></p><a name=\"de-mii-exa-onko-modification-oxaliplatin-request\"> </a><a name=\"de-hcmii-exa-onko-modification-oxaliplatin-request\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-mii-pr-onko-therapieempfehlung-medikation.html\">MII PR Onkologie Therapieempfehlung Medikation</a> version: 2027.0.0-ballot.1</p></div><p><b>status</b>: Stopped</p><p><b>statusReason</b>: <span title=\"Codes:{http://snomed.info/sct 281647001}\">Oxaliplatin discontinued after cycle 6 due to grade 3 peripheral neuropathy (CTCAE). Patient continued with 5-FU + Leucovorin only for remaining 6 cycles.</span></p><p><b>intent</b>: Proposal</p><p><b>medication</b>: <span title=\"Codes:{http://fhir.de/CodeSystem/bfarm/atc L01XA03}\">Oxaliplatin</span></p><p><b>subject</b>: <a href=\"Patient-example-modification.html\">Martin Beispiel  Male, DoB: 1958-11-03</a></p><p><b>authoredOn</b>: 2024-03-05</p><p><b>reasonReference</b>: <a href=\"Condition-mii-exa-onko-ascending-colon-cancer-diagnosis.html\">Condition Bösartige Neubildung: Colon ascendens</a></p><p><b>note</b>: </p><blockquote><div><p>Administered for cycles 1-6 only. Stopped due to cumulative neurotoxicity.</p>\n</div></blockquote></div>"
  },
  "status" : "stopped",
  "statusReason" : {
    "coding" : [{
      "system" : "http://snomed.info/sct",
      "code" : "281647001",
      "display" : "Adverse reaction (disorder)"
    }],
    "text" : "Oxaliplatin discontinued after cycle 6 due to grade 3 peripheral neuropathy (CTCAE). Patient continued with 5-FU + Leucovorin only for remaining 6 cycles."
  },
  "intent" : "proposal",
  "medicationCodeableConcept" : {
    "coding" : [{
      "system" : "http://fhir.de/CodeSystem/bfarm/atc",
      "code" : "L01XA03",
      "display" : "Oxaliplatin"
    }],
    "text" : "Oxaliplatin"
  },
  "subject" : {
    "reference" : "Patient/example-modification"
  },
  "authoredOn" : "2024-03-05",
  "reasonReference" : [{
    "reference" : "Condition/mii-exa-onko-ascending-colon-cancer-diagnosis"
  }],
  "note" : [{
    "text" : "Administered for cycles 1-6 only. Stopped due to cumulative neurotoxicity."
  }]
}