<?xml version="1.0" encoding="UTF-8"?>

<MedicationRequest xmlns="http://hl7.org/fhir">
  <id value="mii-exa-onko-modification-oxaliplatin-request"/>
  <meta>
    <profile value="https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-therapieempfehlung-medikation|2027.0.0-ballot.1"/>
  </meta>
  <language value="de"/>
  <text>
    <status value="generated"/><div xml:lang="de" lang="de"><hr/><p><b>German</b></p><hr/><p class="res-header-id"><b>Generated Narrative: MedicationRequest mii-exa-onko-modification-oxaliplatin-request</b></p><a name="de-mii-exa-onko-modification-oxaliplatin-request"> </a><a name="de-hcmii-exa-onko-modification-oxaliplatin-request"> </a><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px"/><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-mii-pr-onko-therapieempfehlung-medikation.html">MII PR Onkologie Therapieempfehlung Medikation</a> version: 2027.0.0-ballot.1</p></div><p><b>status</b>: Stopped</p><p><b>statusReason</b>: <span title="Codes:{http://snomed.info/sct 281647001}">Oxaliplatin discontinued after cycle 6 due to grade 3 peripheral neuropathy (CTCAE). Patient continued with 5-FU + Leucovorin only for remaining 6 cycles.</span></p><p><b>intent</b>: Proposal</p><p><b>medication</b>: <span title="Codes:{http://fhir.de/CodeSystem/bfarm/atc L01XA03}">Oxaliplatin</span></p><p><b>subject</b>: <a href="Patient-example-modification.html">Martin Beispiel  Male, DoB: 1958-11-03</a></p><p><b>authoredOn</b>: 2024-03-05</p><p><b>reasonReference</b>: <a href="Condition-mii-exa-onko-ascending-colon-cancer-diagnosis.html">Condition Bösartige Neubildung: Colon ascendens</a></p><p><b>note</b>: </p><blockquote><div><p>Administered for cycles 1-6 only. Stopped due to cumulative neurotoxicity.</p>
</div></blockquote></div>
  </text>
  <status value="stopped"/>
  <statusReason>
    <coding>
      <system value="http://snomed.info/sct"/>
      <code value="281647001"/>
      <display value="Adverse reaction (disorder)"/>
    </coding>
    <text value="Oxaliplatin discontinued after cycle 6 due to grade 3 peripheral neuropathy (CTCAE). Patient continued with 5-FU + Leucovorin only for remaining 6 cycles."/>
  </statusReason>
  <intent value="proposal"/>
  <medicationCodeableConcept>
    <coding>
      <system value="http://fhir.de/CodeSystem/bfarm/atc"/>
      <code value="L01XA03"/>
      <display value="Oxaliplatin"/>
    </coding>
    <text value="Oxaliplatin"/>
  </medicationCodeableConcept>
  <subject>
    <reference value="Patient/example-modification"/>
  </subject>
  <authoredOn value="2024-03-05"/>
  <reasonReference>
    <reference value="Condition/mii-exa-onko-ascending-colon-cancer-diagnosis"/>
  </reasonReference>
  <note>
    <text value="Administered for cycles 1-6 only. Stopped due to cumulative neurotoxicity."/>
  </note>
</MedicationRequest>